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Dirks, Remco (author)Brachytherapy (BT) is an essential component in the curative treatment of cervical cancer. With commercial BT implant devices, called applicators, the radioactive sources can only be positioned in fixed intracavitary channels or in a fixed array of interstitial needles. Patient-tailored BT applicators containing individualised needle channels...master thesis 2024
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Garner, E. (author)Background: Despite over a century’s worth of technical improvements, the longterm survivability associated with orthopedic implants continues to fall short. In contrast to earlier designs, implant failure is no longer caused by structural failure of the implant itself. Rather, it results from the implant’s long-term detrimental effects on the...doctoral thesis 2024
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van Bakel, Roan (author)Introduction <br/>An innovative, patient-specific, hip implant was developed for canine patients suffering from developmental hip dysplasia. In a first cohort study, the post-operative positions of the implants deviated with an average of 5 mm when compared to the pre-operatively planned positions. A novel augmented reality (AR) based intra...master thesis 2024
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Tjepkema, Kars (author)Introduction: Speech perception in acoustically challenging environments remains challenging for children with cochlear implants. When considering the implementation of an automatic classifier system in the classroom, it becomes crucial to assess the potential advantages against possible drawbacks.<br/>Consequently, the central question centers...master thesis 2024
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Isaakidou, A. (author), Ganjian, M. (author), van Hoften, R. (author), Cruz Saldivar, M. (author), Leeflang, M.A. (author), Groetsch, A. (author), Wątroba, M. (author), Schwiedrzik, J. (author), Mirzaali, Mohammad J. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The currently available treatments for inner ear disorders often involve systemic drug administration, leading to suboptimal drug concentrations and side effects. Cochlear implants offer a potential solution by providing localized and sustained drug delivery to the cochlea. While the mechanical characterization of both the implants and their...journal article 2024
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Eijkel, B.I.M. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)The antibacterial biofunctionality of bone implants is essential for the prevention and treatment of implant-associated infections (IAI). In vitro co-culture models are utilized to assess this and study bacteria-host cell interactions at the implant interface, aiding our understanding of biomaterial and the immune response against IAI without...review 2024
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Zhu, P. (author), Simón Grau, I. (author), Kokalari, I. (author), Kohane, Daniel S. (author), Rwei, A.Y. (author)Ultrasound is a promising technology to address challenges in drug delivery, including limited drug penetration across physiological barriers and ineffective targeting. Here we provide an overview of the significant advances made in recent years in overcoming technical and pharmacological barriers using ultrasound-assisted drug delivery to...review 2024
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Salandova, M. (author), Leeflang, M.A. (author), Klimopoulou, M. (author), Fratila-Apachitei, E.L. (author), Apachitei, I. (author), Zadpoor, A.A. (author)This study proposes a new concept for an on-demand drug releasing device intended for integration into additively manufactured (i.e., 3D printed) orthopedic implants. The system comprises a surface with conduits connected to a subsurface reservoir used for storage and on-demand release of antimicrobial agents, covered with a cap that prevents...journal article 2024
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Putra, N.E. (author), Moosabeiki, Vahid (author), Leeflang, M.A. (author), Zhou, J. (author), Zadpoor, A.A. (author)Additively manufactured (AM) biodegradable porous iron-manganese (FeMn) alloys have recently been developed as promising bone-substituting biomaterials. However, their corrosion fatigue behavior has not yet been studied. Here, we present the first study on the corrosion fatigue behavior of an extrusion-based AM porous Fe35Mn alloy under...journal article 2024
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Nikita Gopakumar, Nikita (author)Hip replacement surgery, also termed total hip arthroplasty, is a surgical intervention intended to substitute a deteriorated or dysfunctional hip joint with an artificial prosthesis. This procedure is commonly indicated for individuals experiencing severe hip discomfort resulting from conditions like osteoarthritis, rheumatoid arthritis, hip...master thesis 2023
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Kuitems, Iris (author)This thesis outlines the project conducted at HollandPTC for the Master Biomedical Engineering, track Medical Physics, at Delft University of Technology. <br/><br/>Metal implants create dosimetric uncertainties in treatment planning and delivery for proton therapy. The purpose of this thesis was to determine the most suitable treatment planning...master thesis 2023
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van Marrewijk, Esther (author)Introduction<br/>Reverberation causes a reduced speech perception in cochlear implant (CI) users. Therefore, a dereverberation method was proposed based on the weighted prediction error (WPE) algorithm with input from a deep neural network. The speech intelligibility for normal and hearing-aided listeners is improved by cancelling the late...master thesis 2023
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Yuan, T. (author)The thumb finger is indispensable for an independent daily life. Implant replacement, which aims to restore joint mobility and functionality, is one of the surgical treatments for patients with osteoarthritis at the thumb-base. However, current designs and the biomechanical understanding of the thumb-base joint are inadequate. Small bone size,...doctoral thesis 2023
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Mol, Tessa (author)Achieving appropriate soft tissue tension around the hip joint is an important factor for achieving hip stability after Total Hip Arthroplasty (THA). Hip instability leads to dislocations, pain, and is a common reason for early revision surgery. The current soft tissue tension assessments available during surgery rely on experience, and...master thesis 2023
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Hou, Sophia (author)The objective of this thesis project is to develop an economically viable design for a titanium total ossicular replacement prosthesis (TORP) that caters to the needs of low- and middle-income countries (LMICs). The author focused on addressing the problem from the manufacturing aspect and two primary approaches, additive manufacturing (AM or...master thesis 2023
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van Tunen, Rick (author)Congenital heart disease (CHD) affects almost 1% of newborns. Right ventricular outflow tract (RVOT) CHD affects 20% of newborns and includes anomalies such as tetralogy of Fallot (TOF) with or without pulmonary atresia, transposition of the great vessels, and truncus arteriosus. All these anomalies require RVOT reconstruction. Prosthetic heart...master thesis 2023
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van Damme, Niels (author)In the emerging research field of bioelectronic medicine, it has been indicated that neuromodulation of the Vagus Nerve (VN) has the potential to treat various conditions such as epilepsy, depression, and autoimmune diseases. In order to reduce side effects, as well as to increase the effectiveness of the delivered therapy, sub-fascicle...master thesis 2023
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De Boeck, Jan (author)In the context of prosthetic devices, the absence of natural sensory feedback poses a significant challenge, leading to limited proprioceptive sensation and reduced control over artificial limbs. This study explores the potential of establishing a magnetic connection between prosthetic devices and muscles to enhance proprioceptive feedback and...master thesis 2023
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Khan, Afaq (author)The mechanical failure of a temporomandibular joint (TMJ) replacement system can stem from various factors, with one notable cause being the unnatural kinematics and loading observed in prosthetic joint function. Given that,. the primary objective of the study was to investigate whether including functionally graded materials (FGMs) at the site...master thesis 2023
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- van Gemert, Simon (author) master thesis 2023