Searched for: subject%3A%22Intensity%255C%2BModulated%255C%2BProton%255C%2BTherapy%22
(1 - 6 of 6)
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Rojo-Santiago, Jesús (author), Korevaar, Erik (author), Perko, Z. (author), Both, Stefan (author), Habraken, S.J.M. (author), Hoogeman, M.S. (author)
Background and purpose: In the Netherlands, head-and-neck cancer (HNC) patients are referred for proton therapy (PT) through model-based selection (MBS). However, treatment errors may compromise adequate CTV dose. Our aims are: (i) to derive probabilistic plan evaluation metrics on the CTV consistent with clinical metrics; (ii) to evaluate...
journal article 2023
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Rojo-Santiago, Jesús (author), Habraken, S.J.M. (author), Romero, Alejandra Méndez (author), Lathouwers, D. (author), Wang, Yibing (author), Perko, Z. (author), Hoogeman, M.S. (author)
Objective. The Dutch proton robustness evaluation protocol prescribes the dose of the clinical target volume (CTV) to the voxel-wise minimum (VWmin) dose of 28 scenarios. This results in a consistent but conservative near-minimum CTV dose (D98%,CTV). In this study, we analyzed (i) the correlation between VWmin/voxel-wise maximum (VWmax)...
journal article 2023
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Oud, Michelle (author), Breedveld, Sebastiaan (author), Giżyńska, Marta (author), Kroesen, Michiel (author), Hutschemaekers, Stefan (author), Habraken, S.J.M. (author), Petit, Steven (author), Perko, Z. (author), Heijmen, Ben (author), Hoogeman, M.S. (author)
Background and purpose: In intensity modulated proton therapy (IMPT), the impact of setup errors and anatomical changes is commonly mitigated by robust optimization with population-based setup robustness (SR) settings and offline replanning. In this study we propose and evaluate an alternative approach based on daily plan selection from...
journal article 2022
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Rojo-Santiago, Jesús (author), Habraken, S.J.M. (author), Lathouwers, D. (author), Méndez Romero, Alejandra (author), Perko, Z. (author), Hoogeman, M.S. (author)
Background and purpose: Scenario-based robust optimization and evaluation are commonly used in proton therapy (PT) with pencil beam scanning (PBS) to ensure adequate dose to the clinical target volume (CTV). However, a statistically accurate assessment of the clinical application of this approach is lacking. In this study, we assess target...
journal article 2021
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Pastor Serrano, O. (author), Habraken, S.J.M. (author), Lathouwers, D. (author), Hoogeman, M.S. (author), Schaart, D.R. (author), Perko, Z. (author)
Breathing interplay effects in Intensity Modulated Proton Therapy (IMPT) arise from the interaction between target motion and the scanning beam. Assessing the detrimental effect of interplay and the clinical robustness of several mitigation techniques requires statistical evaluation procedures that take into account the variability of...
journal article 2021
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Qiao, Yuchuan (author), Jagt, Thyrza (author), Hoogeman, M.S. (author), Lelieveldt, B.P.F. (author), Staring, M. (author)
Objective: Our goal was to investigate the performance of an open source deformable image registration package, elastix, for fast and robust contour propagation in the context of online-adaptive intensity-modulated proton therapy (IMPT) for prostate cancer. Methods: A planning and 7–10 repeat CT scans were available of 18 prostate cancer...
journal article 2019
Searched for: subject%3A%22Intensity%255C%2BModulated%255C%2BProton%255C%2BTherapy%22
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