Searched for: subject%3A%22Lung%22
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Doornbos, Marie-Claire (author)
Objective: This study introduces a novel deep-learning-based orientation recognition approach for detecting intraoperative lung orientation during robot-assisted anatomical resections, including lobectomy and segmentectomy. This method can potentially aid in anatomical structure identification, facilitate training and education, improve...
master thesis 2024
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Walstra, Anna (author)
<b>Objective</b>: The two-fold aim of this phantom study was first to evaluate the accuracy of pulmonary nodule detection for lung cancer screening at progressively lower dose levels of photon-counting computed tomography (PC-CT) and, second, to objectively compare the image quality across different acquisition and reconstruction settings,...
master thesis 2023
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van der Sar, Iris G. (author), van Jaarsveld, Nynke (author), Spiekerman, Imme A. (author), Toxopeus, Floor J. (author), Langens, Quint L. (author), Wijsenbeek, Marlies S. (author), Dauwels, J.H.G. (author), Moor, Catharina C. (author)
Electronic nose (eNose) technology is an emerging diagnostic application, using artificial intelligence to classify human breath patterns. These patterns can be used to diagnose medical conditions. Sarcoidosis is an often difficult to diagnose disease, as no standard procedure or conclusive test exists. An accurate diagnostic model based on...
journal article 2023
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Hintzen, Annemijn (author)
Elongated mechanical ventilation is associated with ventilator-induced lung injury (VILI), diaphragmatic muscle atrophy, patient discomfort, increased mortality rates and higher healthcare costs. However, hospitals are lacking in user-friendly, affordable and accurate methods to measure the decline the respiratory condition. Computed tomography ...
master thesis 2022
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den Boer, Sophie (author)
In vitro models are fundamental in the study of cell behaviour, the physiological function of organs, and their response to drugs and toxins. However, the shortage of accurate and reliable in vitro models calls for the development of in vitro lung models that better recapitulate lung physiology and pathology. Lung-on- a-chip models are promising...
master thesis 2022
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Visser, Jeffrey (author)
<b>Background</b>: The prevention of ventilator-induced lung injury (VILI) is an important topic in criticalcare. Lung overdistention is a great attributor to VILI. Regional evaluation of the pulmonary mechanicsis a relatively new method and is currently being studied using electrical impedance tomography (EIT)and computed tomography (CT)....
master thesis 2022
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Allahabadi, H. (author), Amann, J. (author), Balot, I. (author), Beretta, A. (author), Binkley, C. (author), Bozenhard, J. (author), Bruneault, F. (author), Brusseau, J. (author), Umbrello, S. (author)
This article’s main contributions are twofold: 1) to demonstrate how to apply the general European Union’s High-Level Expert Group’s (EU HLEG) guidelines for trustworthy AI in practice for the domain of healthcare and 2) to investigate the research question of what does “trustworthy AI” mean at the time of the COVID-19 pandemic. To this end, we...
journal article 2022
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Zabreen Nissar, Zabreen (author)
In vitro models are used for studying the physiological function of an organ, disease modelling and drug testing. Over the last decade, since their first commercial introduction, organ-on-a-chip (OOC) technology has proved to be able to recreate aspects of organ function that conventional in vitro models, such as cell culture wells and cell...
master thesis 2021
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Lee, Wai Tung (author), Zheng, Gang (author), Talbot, Cavin L. (author), Tong, Xin (author), D'Adam, Tim (author), Parnell, S.R. (author), de Veer, Michael (author), Jenkin, Graham (author), Polglase, Graeme R. (author)
We report the design, construction, and initial tests of a hyperpolariser to produce polarised <sup>129</sup>Xe and <sup>3</sup>He gas for medical imaging of the lung. The hyperpolariser uses the Spin-Exchange Optical Pumping method to polarise the nuclear spins of the isotopic gas. Batch mode operation was chosen for the design to produce...
journal article 2021
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Angus, Lindsay (author), Starmans, M.P.A. (author), Rajicic, Ana (author), Odink, Arlette E. (author), Jalving, Mathilde (author), Niessen, W.J. (author), Visser, Jacob J. (author), Sleijfer, Stefan (author), Klein, Stefan (author), van der Veldt, Astrid A.M. (author)
Patients with BRAF mutated (BRAF-mt) metastatic melanoma benefit significantly from treatment with BRAF inhibitors. Currently, the BRAF status is determined on archival tumor tissue or on fresh tumor tissue from an invasive biopsy. The aim of this study was to evaluate whether radiomics can predict the BRAF status in a non-invasive manner....
journal article 2021
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La Zara, D. (author), Sun, F. (author), Zhang, F. (author), Franek, Frans (author), Balogh Sivars, Kinga (author), Horndahl, Jenny (author), Bates, Stephanie (author), Brännström, Marie (author), van Ommen, J.R. (author)
Ideal controlled pulmonary drug delivery systems provide sustained release by retarding lung clearance mechanisms and efficient lung deposition to maintain therapeutic concentrations over prolonged time. Here, we use atomic layer deposition (ALD) to simultaneously tailor the release and aerosolization properties of inhaled drug particles...
journal article 2021
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Braas, Ruben (author)
Knowledge of particle deposition is important in clinical settings or when discussing environmental effects of aerosols on humans.<br/>Particle deposition in the human respiratory tract is determined by breathing patterns and lung morphology, as well as particle properties and deposition mechanisms.<br/>In this study we develop a 1-dimensional...
bachelor thesis 2020
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Groen, Jort (author)
Radiotherapy (RT) is an important modality in treatment against cancer. Developments in this modality are necessary for improvement of patient complications and survival. Aside from fractionation and precise irradiation, FLASH radiotherapy could be a third way to significantly increase the therapeutic window of radiotherapy.The FLASH effect is a...
master thesis 2020
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Ahmad, Arslan (author), van der Wens, Patrick (author), Baken, Kirsten (author), de Waal, Luuk (author), Bhattacharya, Prosun (author), Stuyfzand, Pieter Jan (author)
Arsenic (As) is a highly toxic element which naturally occurs in drinking water. In spite of substantial evidence on the association between many illnesses and chronic consumption of As, there is still a considerable uncertainty about the health risks due to low As concentrations in drinking water. In the Netherlands, drinking water companies...
review 2020
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Mui, Claudia (author)
Personalising patient education is an important aspect that is needed for patients to become active in decision making and their treatment. Standardised methods are not enough and personalisation can make an improvement in healthcare by focussing more on the patient. This report focusses on patient education at the Albert Schweitzer Hospital...
master thesis 2019
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Engelen, Myrthe (author)
Survival in lung cancer patients relies on correct intraoperative identification and resection of lung nodules. We hypothesize that epidermal growth factor receptor-targeted (EGFR) intraoperative molecular imaging can help improve localization of lung nodules. In a clinical study, we evaluated the use of panitumumab-IRDye800 to determine if...
master thesis 2019
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Kenjeres, S. (author), Tjin, J.L. (author)
In the present study, we investigate the concept of the targeted delivery of pharmaceutical drug aerosols in an anatomically realistic geometry of the human upper and central respiratory system. The geometry considered extends from the mouth inlet to the eighth generation of the bronchial bifurcations and is identical to the phantom model...
journal article 2017
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Tolios, I. (author)
Lung tumors are heterogeneous entities consisting of distinct intra-tumor regions with different biological characteristics. Currently, the only means to explore and analyze these distinct intra-tumor regions is to inspect several image acquisitions. From these, per-voxel functional tissue parameters, representative of tissue properties, are...
master thesis 2016
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Marien, Eyra (author), Meister, Michael (author), Muley, Thomas (author), del Pulgar, Teresa Gomez (author), Derua, Rita (author), Spraggins, Jeffrey M. (author), Van de Plas, Raf (author), Vanderhoydonc, Frank (author), Machiels, Jelle (author), Binda, Maria Mercedes (author), Dehairs, Jonas (author), Willette-Brown, Jami (author), Hu, Yinling (author), Dienemann, Hendrik (author), Thomas, Michael (author), Schnabe, Philipp A. (author), Caprioli, Richard M. (author), Lacal, Juan Carlos (author), Waelkens, Etienne (author), Swinnen, Johannes V. (author)
Lung cancer is the leading cause of cancer death. Beyond first line treatment, few therapeutic options are available, particularly for squamous cell carcinoma (SCC). Here, we have explored the phospholipidomes of 30 human SCCs and found that they almost invariably (in 96.7% of cases) contain phospholipids with longer acyl chains compared to...
journal article 2016
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Marien, E. (author), Meister, M. (author), Muley, T. (author), Fieuws, S. (author), Bordel, S. (author), Derua, R. (author), Spraggins, J. (author), Van de Plas, R. (author), Dehairs, J. (author), Wouters, J. (author), Bagadi, M. (author), Dienemann, H. (author), Thomas, M. (author), Schnabel, P.A. (author), Caprioli, R.M. (author), Waelkens, E. (author), Swinnen, J.V. (author)
Non-small cell lung cancer (NSCLC) is the leading cause of cancer death globally. To develop better diagnostics and more effective treatments, research in the past decades has focused on identification of molecular changes in the genome, transcriptome, proteome, and more recently also the metabolome. Phospholipids, which nevertheless play a...
journal article 2015
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