Searched for: subject%3A%22Macrophages%22
(1 - 18 of 18)
document
Jansen, Imke (author), Cahalane, Rachel (author), Hengst, Ranmadusha (author), Akyildiz, A.C. (author), Farrell, Eric (author), Gijsen, F.J.H. (author), Aikawa, Elena (author), van der Heiden, Kim (author), Wissing, Tamar (author)
The rupture of an atherosclerotic plaque cap overlying a lipid pool and/or necrotic core can lead to thrombotic cardiovascular events. In essence, the rupture of the plaque cap is a mechanical event, which occurs when the local stress exceeds the local tissue strength. However, due to inter- and intra-cap heterogeneity, the resulting ultimate...
review 2024
document
Warmink, Kelly (author), Vinod, Prateeksha (author), Korthagen, Nicoline M. (author), Weinans, Harrie (author), Rios, Jaqueline L. (author)
Osteoarthritis (OA) is a common and debilitating joint disorder that leads to progressive joint breakdown and loss of articular cartilage. Accompanied by a state of low-grade inflammation, its etiology extends beyond that of a wear-and-tear disease, and the immune system might have a role in its initiation and progression. Obesity, which is...
review 2023
document
Garmendia Urdalleta, A. (author), van Poll, M.A. (author), Fahy, Niamh (author), Witte-Bouma, Janneke (author), van Wamel, Willem (author), Apachitei, I. (author), Zadpoor, A.A. (author), Fratila-Apachitei, E.L. (author), Farrell, Eric (author)
Macrophage responses following the implantation of orthopaedic implants are essential for successful implant integration in the body, partly through intimate crosstalk with human marrow stromal cells (hMSCs) in the process of new bone formation. Additive manufacturing (AM) and plasma electrolytic oxidation (PEO) in the presence of silver...
journal article 2023
document
Warmink, K. (author), Rios, J. L. (author), van Valkengoed, D. R. (author), Vinod, P. (author), Korthagen, N. M. (author), Weinans, Harrie (author)
Introduction: Obesogenic diets aggravate osteoarthritis (OA) by inducing low-grade systemic inflammation, and diet composition may affect OA severity. Here, we investigated the effect of diet on joint damage and inflammation in an OA rat model. Methods: Wistar-Han rats (n = 24) were fed a chow, a high-fat (HF) diet, or a high-fat/high-sucrose...
journal article 2023
document
Warmink, Kelly (author), Siebelt, Michiel (author), Low, Philip S. (author), Riemers, Frank M. (author), Wang, Bingbing (author), Plomp, Saskia G.M. (author), Tryfonidou, Marianna A. (author), van Weeren, P. René (author), Weinans, Harrie (author), Korthagen, Nicoline M. (author)
OBJECTIVE: Folate receptor beta (FR-β) has been used as a clinical marker and target in multiple inflammatory diseases, including osteoarthritis (OA) and rheumatoid arthritis (RA). However, the conditions under which FR-β+ macrophages arise remain unclear and could be affected by corticosteroids. Therefore, we studied FR-β expression in vitro...
journal article 2022
document
Wesdorp, Marinus A. (author), Bastiaansen-Jenniskens, Yvonne M. (author), Capar, Serdar (author), Verhaar, Jan A.N. (author), Narcisi, R. (author), van Osch, G.J.V.M. (author)
OBJECTIVE: Inflammation is known to negatively affect cartilage repair. However, it is unclear how inflammation influences the migration of mesenchymal stromal cells (MSCs) from the underlying bone marrow into the defect. We therefore aimed to investigate how synovial inflammation influences MSC migration, and whether modulation of...
journal article 2022
document
Garmendia Urdalleta, Amaia (author)
Background: Despite the considerable development of the field of orthopedic implants in the past century, complications including poor bone ingrowth and implant associated infection (IAI) persist to this day, causing a huge burden to millions of patients and the healthcare systems worldwide. Additive manufacturing (AM) and the subsequent surface...
master thesis 2021
document
Ferrao Blanco, Mauricio N. (author), Bastiaansen-Jenniskens, Yvonne M. (author), Chambers, Mark G. (author), Pitsillides, Andrew A. (author), Narcisi, Roberto (author), van Osch, G.J.V.M. (author)
Objective: In osteoarthritis, chondrocytes tend to acquire a hypertrophic phenotype, which contributes to the modification of the extracellular matrix, resulting in permanent cartilage changes. In mouse chondrocytes, pro-inflammatory macrophages and pro-inflammatory cytokines have been shown to stimulate hypertrophy via the activation of the...
journal article 2021
document
Razzi, F. (author), Fratila-Apachitei, E.L. (author), Fahy, N. (author), Bastiaansen-Jenniskens, Yvonne M. (author), Apachitei, I. (author), Farrell, E. (author), Zadpoor, A.A. (author)
Additive manufacturing (AM) techniques have provided many opportunities for the rational design of porous metallic biomaterials with complex and precisely controlled topologies that give rise to unprecedented combinations of mechanical, physical, and biological properties. These favorable properties can be enhanced by surface...
journal article 2020
document
Barrett, Hilary E. (author), Meester, Eric J. (author), van Gaalen, Kim (author), van der Heiden, Kim (author), Krenning, Boudewijn J. (author), Beekman, F.J. (author), Verhagen, H. J. (author), de Jong, M. (author), Gijsen, F.J.H. (author)
Purpose: Atherosclerotic plaque development and progression signifies a complex inflammatory disease mediated by a multitude of proinflammatory leukocyte subsets. Using single photon emission computed tomography (SPECT) coupled with computed tomography (CT), this study tested a new dual-isotope acquisition protocol to assess each radiotracer...
journal article 2020
document
van Poll, Mathijs (author)
Orthopedic implants used for total joint replacements are under a high clinical demand. Although most total joint replacements are successful, premature failures are still affecting tens of thousands of people annually. The major causes of implant failure are aseptic loosening and bacterial infections. To overcome these issues, multifunctional...
master thesis 2019
document
Isaakidou, Katerina (author)
Objective: Advances in the field of biomaterials have positively affected implant acceptance and nowadays nanostructured surfaces are known to have a positive effect on bone regeneration. The development of the field of osteoimmunology has contributed to a steadily increasing interest towards the investigation of the immunomodulatory effect of...
master thesis 2019
document
de Kruijff, R.M. (author), Raavé, René (author), Kip, Annemarie (author), Molkenboer-Kuenen, Janneke (author), Roobol, Stefan J. (author), Essers, Jeroen (author), Heskamp, Sandra (author), Denkova, A.G. (author)
The use of nanoparticles as tumor-targeting agents is steadily increasing, and the influence of nanoparticle characteristics such as size and stealthiness have been established for a large number of nanocarrier systems. However, not much is known about the impact of tumor presence on nanocarrier circulation times. This paper reports on the...
journal article 2019
document
Kuil, Laura E. (author), Oosterhof, Nynke (author), Geurts, S.N. (author), Van Der Linde, Herma C. (author), Meijering, H.W. (author), Van Ham, Tjakko J. (author)
Microglia are brain-resident macrophages, which have specialized functions important in brain development and in disease. They colonize the brain in early embryonic stages, but few factors that drive the migration of yolk sac macrophages (YSMs) into the embryonic brain, or regulate their acquisition of specialized properties, are currently...
journal article 2019
document
Razzi, Francesca (author)
Titanium orthopaedic biomaterials to replace degenerated joint surface, improve bone regeneration and fixation are studied and used worldwide. However, not always biomaterial implantation is successful, and the main causes of implant failure remain implant associated infections (IAI) and poor osseointegration. In the recent years, additive...
master thesis 2018
document
de Visser, H.M. (author), Korthagen, NM (author), Müller, C. (author), Ramakers, R.M. (author), Krijger, G.C. (author), Lafeber, F.P.J.G. (author), Beekman, F.J. (author), Mastbergen, S.C. (author), Weinans, Harrie (author)
Objective. To evaluate the presence and localization of folate receptor expressing macrophages in the rat groove model of osteoarthritis and determine the suitability of a new folate conjugate with albumin-binding entity (cm09) for in vivo SPECT (single-photon emission computed tomography) analysis. Design. In male Wistar rats, local cartilage...
journal article 2018
document
Liu, Shengnan (author), Sotomi, Yohei (author), Eggermont, Jeroen (author), Nakazawa, Gaku (author), Torii, Sho (author), Ijichi, Takeshi (author), Onuma, Yoshinobu (author), Serruys, Patrick W. (author), Lelieveldt, B.P.F. (author), Dijkstra, J. (author)
An important application of intravascular optical coherence tomography (IVOCT) for atherosclerotic tissue analysis is using it to estimate attenuation and backscatter coefficients. This work aims at exploring the potential of the attenuation coefficient, a proposed backscatter term, and image intensities in distinguishing different...
journal article 2017
document
Kersten, Kelly (author), Coffelt, Seth B. (author), Hoogstraat, Marlous (author), Verstegen, Niels J.M. (author), Vrijland, Kim (author), Ciampricotti, Metamia (author), Doornebal, Chris W. (author), Hau, Cheei-Sing (author), Wellenstein, Max D. (author), Salvagno, Camilla (author), Doshi, Parul (author), Lips, Esther H. (author), Wessels, L.F.A. (author), de Visser, Karin E. (author)
Patients with primary solid malignancies frequently exhibit signs of systemic inflammation. Notably, elevated levels of neutrophils and their associated soluble mediators are regularly observed in cancer patients, and correlate with reduced survival and increased metastasis formation. Recently, we demonstrated a mechanistic link between...
journal article 2017
Searched for: subject%3A%22Macrophages%22
(1 - 18 of 18)