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Multi-scale in silico and ex silico mechanics of 3D printed cochlear implants for local drug delivery

Isaakidou, A. (author), Ganjian, M. (author), van Hoften, R. (author), Cruz Saldivar, M. (author), Leeflang, M.A. (author), Groetsch, A. (author), Wątroba, M. (author), Schwiedrzik, J. (author), Mirzaali, Mohammad J. (author), Apachitei, I. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)

The currently available treatments for inner ear disorders often involve systemic drug administration, leading to suboptimal drug concentrations and side effects. Cochlear implants offer a potential solution by providing localized and sustained drug delivery to the cochlea. While the mechanical characterization of both the implants and their...

journal article 2024

document

Shape-locking in architected materials through 3D printed magnetically activated joints

de Jong, P.H. (author), Salvatori, Y.S. (author), Libonati, F. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)

Shape morphing is the ability of objects to adapt to different shapes and reduce stress concentrations through increased contact area. This is a common trait of natural and engineered objects and has several applications in, among others, soft robotics and orthopedic implants. Shape morphing is achieved through flexible materials or rigid...

journal article 2023

document

Deep Learning for Size-Agnostic Inverse Design of Random-Network 3D Printed Mechanical Metamaterials

Pahlavani, H. (author), Tsifoutis-Kazolis, Kostas (author), Cruz Saldivar, M. (author), Mody, Prerak (author), Zhou, J. (author), Mirzaali, Mohammad J. (author), Zadpoor, A.A. (author)

Practical applications of mechanical metamaterials often involve solving inverse problems aimed at finding microarchitectures that give rise to certain properties. The limited resolution of additive manufacturing techniques often requires solving such inverse problems for specific specimen sizes. Moreover, the candidate microarchitectures...

journal article 2023

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Rational design and additive manufacturing of grain boundary-inspired, multi-architecture lattice structures

Yang, J. (author), Chen, Xiaohong (author), Sun, Yuanxi (author), Feng, Chen (author), Yang, Zheng (author), Zadpoor, A.A. (author), Mirzaali, Mohammad J. (author), Bai, Long (author)

The advent of additive manufacturing has facilitated the design and fabrication of hybrid lattice structures with multiple morphologies. These structures combine multiple distinct architectures into a single structure with an exceptional performance that far exceeds that of each constituting architecture. However, combining strut-based...

journal article 2023

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Additive manufacturing of vascular stents

Li, Yageng (author), Shi, Yixuan (author), Lu, Yuchen (author), Li, Xuan (author), Zhou, J. (author), Zadpoor, A.A. (author), Wang, Luning (author)

With the advancement of additive manufacturing (AM), customized vascular stents can now be fabricated to fit the curvatures and sizes of a narrowed or blocked blood vessel, thereby reducing the possibility of thrombosis and restenosis. More importantly, AM enables the design and fabrication of complex and functional stent unit cells that...

review 2023

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Design of a 3D-printed hand prosthesis featuring articulated bio-inspired fingers

Cuellar Lopez, J.S. (author), Plettenburg, D.H. (author), Zadpoor, A.A. (author), Breedveld, P. (author), Smit, G. (author)

Various upper-limb prostheses have been designed for 3D printing but only a few of them are based on bio-inspired design principles and many anatomical details are not typically incorporated even though 3D printing offers advantages that facilitate the application of such design principles. We therefore aimed to apply a bio-inspired approach...

journal article 2021

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Additive manufacturing of non-assembly deployable mechanisms for the treatment of large bony defects

Leeflang, M.A. (author), Bobbert, F.S.L. (author), Zadpoor, A.A. (author)

Porous biomaterials are often used to treat large bony defects or fractured vertebras. Most of such biomaterials are made of metals and their alloys and have a pre-defined, fixed shape. Due to their predefined fixed shape, however, they are not suitable for implantation through minimally invasive surgical procedures. To overcome this problem,...

journal article 2021

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3D-Printed Submicron Patterns Reveal the Interrelation between Cell Adhesion, Cell Mechanics, and Osteogenesis

Nouri Goushki, M. (author), Angeloni, L. (author), Modaresifar, K. (author), Minneboo, M.B. (author), Boukany, P. (author), Mirzaali, Mohammad J. (author), Ghatkesar, M.K. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)

The surface topography of implantable devices is of crucial importance for guiding the cascade of events that starts from the initial contact of the cells with the surface and continues until the complete integration of the device in its immediate environment. There is, however, limited quantitative information available regarding the...

journal article 2021

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Curvature Induced by Deflection in Thick Meta-Plates

Mirzaali, Mohammad J. (author), Ghorbani, Aref (author), Nakatani, Kenichi (author), Nouri Goushki, M. (author), Tümer, N. (author), Callens, S.J.P. (author), Janbaz, S. (author), Accardo, A. (author), Bico, José (author), Habibi, Mehdi (author), Zadpoor, A.A. (author)

The design of advanced functional devices often requires the use of intrinsically curved geometries that belong to the realm of non-Euclidean geometry and remain a challenge for traditional engineering approaches. Here, it is shown how the simple deflection of thick meta-plates based on hexagonal cellular mesostructures can be used to achieve...

journal article 2021

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Additively manufactured biodegradable porous metals

Li, Y. (author), Jahr, H. (author), Zhou, J. (author), Zadpoor, A.A. (author)

Partially due to the unavailability of ideal bone substitutes, the treatment of large bony defects remains one of the most important challenges of orthopedic surgery. Additively manufactured (AM) biodegradable porous metals that have emerged since 2018 provide unprecedented opportunities for fulfilling the requirements of an ideal bone...

review 2020

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Russian doll deployable meta-implants: Fusion of kirigami, origami, and multi-stability

Bobbert, F.S.L. (author), Janbaz, S. (author), van Manen, T. (author), Li, Y. (author), Zadpoor, A.A. (author)

Deployable meta-implants aim to minimize the invasiveness of orthopaedic surgeries by allowing for changes in their shape and size that are triggered by an external stimulus. Multi-stability enables deployable implants to transform their shape from some compact retracted state to the deployed state where they take their full sizes and are...

journal article 2020

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Additively manufactured biodegradable porous zinc

Li, Y. (author), Pavanram, P. (author), Zhou, J. (author), Lietaert, K. (author), Taheri, P. (author), Li, W. (author), San, H. (author), Leeflang, M.A. (author), Mol, J.M.C. (author), Jahr, H. (author), Zadpoor, A.A. (author)

Additively manufacturing (AM) opens up the possibility for biodegradable metals to possess uniquely combined characteristics that are desired for bone substitution, including bone-mimicking mechanical properties, topologically ordered porous structure, pore interconnectivity and biodegradability. Zinc is considered to be one of the promising...

journal article 2020

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Functional evaluation of a non-assembly 3D-printed hand prosthesis

Cuellar Lopez, J.S. (author), Smit, G. (author), Breedveld, P. (author), Zadpoor, A.A. (author), Plettenburg, D.H. (author)

In developing countries, the access of amputees to prosthetic devices is very limited. In a way to increase accessibility of prosthetic hands, we have recently developed a new approach for the design and 3D printing of non-assembly active hand prostheses using inexpensive 3D printers working on the basis of material extrusion technology. This...

journal article 2019

document

Non-auxetic mechanical metamaterials

de Jonge, Christa P. (author), Kolken, H.M.A. (author), Zadpoor, A.A. (author)

The concept of "mechanical metamaterials" has become increasingly popular, since their macro-scale characteristics can be designed to exhibit unusual combinations of mechanical properties on the micro-scale. The advances in additive manufacturing (AM, three-dimensional printing) techniques have boosted the fabrication of these mechanical...

review 2019

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A review of the fatigue behavior of 3D printed polymers

Safai, Lauren (author), Cuellar Lopez, J.S. (author), Smit, G. (author), Zadpoor, A.A. (author)

As additive manufacturing of polymeric materials is becoming more prevalent throughout industry and research communities, it is important to ensure that 3D printed parts are able to withstand mechanical and environmental stresses that occur when in use, including the sub-critical cyclic loads that could result in fatigue crack propagation and...

review 2019

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Additive manufacturing of non-assembly mechanisms

Cuellar Lopez, J.S. (author), Smit, G. (author), Plettenburg, D.H. (author), Zadpoor, A.A. (author)

Fabrication of complex and multi-articulated mechanisms is often seen as a time consuming and demanding process. The development of functional multi-articulated mechanisms that could be fabricated in a single step without the need for post-manufacturing assembly is therefore very attractive. Additive manufacturing (AM) has been pointed out as...

review 2018

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Additively manufactured biodegradable porous iron

Li, Y. (author), Jahr, H. (author), Lietaert, K. (author), Pavanram, P. (author), Yilmaz, A. (author), Fockaert, L.I. (author), Leeflang, M.A. (author), Pouran, B. (author), Gonzalez Garcia, Y. (author), Weinans, Harrie (author), Mol, J.M.C. (author), Zhou, J. (author), Zadpoor, A.A. (author)

Additively manufactured (AM) topologically ordered porous metallic biomaterials with the proper biodegradation profile offer a unique combination of properties ideal for bone regeneration. These include a fully interconnected porous structure, bone-mimicking mechanical properties, and the possibility of fully regenerating bony defects. Most...

journal article 2018

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Fatigue and quasi-static mechanical behavior of bio-degradable porous biomaterials based on magnesium alloys

Hedayati, R. (author), Ahmadi, S.M. (author), Lietaert, K. (author), Tümer, N. (author), Li, Y (author), Amin Yavari, S. (author), Zadpoor, A.A. (author)

Magnesium and its alloys have the intrinsic capability of degrading over time in vivo without leaving toxic degradation products. They are therefore suitable for use as biodegradable scaffolds that are replaced by the regenerated tissues. One of the main concerns for such applications, particularly in load-bearing areas, is the sufficient...

journal article 2018

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Ten guidelines for the design of non-assembly mechanisms: The case of 3D-printed prosthetic hands

Cuellar Lopez, J.S. (author), Smit, G. (author), Zadpoor, A.A. (author), Breedveld, P. (author)

In developing countries, prosthetic workshops are limited, difficult to reach, or even non-existent. Especially, fabrication of active, multi-articulated, and personalized hand prosthetic devices is often seen as a time-consuming and demanding process. An active prosthetic hand made through the fused deposition modelling technology and fully...

journal article 2018

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Multi-material 3D printed mechanical metamaterials: Rational design of elastic properties through spatial distribution of hard and soft phases

Mirzaali, Mohammad J. (author), Caracciolo, A. (author), Pahlavani, H. (author), Janbaz, S. (author), Vergani, L. (author), Zadpoor, A.A. (author)

Up until recently, the rational design of mechanical metamaterials has usually involved devising geometrical arrangements of micro-architectures that deliver unusual properties on the macro-scale. A less explored route to rational design is spatially distributing materials with different properties within lattice structures to achieve the...

journal article 2018