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Almeida Benalcazar, E.F. (author)The mitigation of global warming requires an urgent shift from the fossil fuel-based productive matrix currently in place. Technological platforms are being developed to reduce the amount of carbon of fossil origin, which is emitted to the atmosphere as a side-product from the production of energy. Gas mixtures containing CO, H2 and CO2 are...doctoral thesis 2023
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van Aalst, A.C.A. (author)The production of ethanol by the yeast Saccharomyces cerevisiae remains the process in industrial biotechnology with the largest product volume (ca. 100 million litres annually in 2022). Carbon losses occur due to the formation of biomass and glycerol, which can account for at least 8% of the product. Under anaerobic conditions, formation of...doctoral thesis 2023
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Perli, T. (author)The increase in world population together with an unsustainable and fossil fuel-based economy are at the root of the significant increase in the average global temperature since the pre-industrial era. Switching to a more sustainable and circular bio-based economy is one of the main pillars included in the Paris agreement aimed at reducing green...doctoral thesis 2021
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Gabriel Guedes da Silva, L. (author)Cells are complex systems continuously exposed to changing, dynamic environments. Understanding how cells respond and adapt is of great interest not only from a fundamental viewpoint but also for the development of solutions for current challenges in medical, industrial and environmental research fields.<br/><br/>In this thesis, the bacterial...doctoral thesis 2021
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Büke, F. (author)Bacteria have been an integral part of human life since the ancient times either as cooperative tenants living in and around us or as constant threats to our health and wellbeing. Since prehistoric times we unknowingly used them as tools of fermentation and fought against them with haphazardly discovered natural remedies. Today, after more than...doctoral thesis 2020
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Rombouts, J.L. (author)Microbial fermentations are a key process in naturally and man-made ecosystems. Microbial fermentations play a key role in creating and digesting our food and they are useful in designing bioprocesses that can produce biogas, biofuels, bioplastics, and many other functional molecules (Chapter 1). Furthermore, studying the competition and...doctoral thesis 2020
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Shomar Monges, H. (author)For millennia, humans have used microbes to produce industrial products of social and economical value through fermentation processes. In recent years, the application of engineering principles to microbiology have dramatically expanded our ability to modify and optimize microbes for the production of a wide variety of commercial products from...doctoral thesis 2019
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Icibaci, L.M. (author)This research departs from the desire to understand the practice of reuse of building products from a systemic standpoint, representing a network of multiple factors influencing the process of reusing. Through the Industrial Ecology theoretical framework, these relations are dynamic and contextually bounded defining the commercial feasibility of...doctoral thesis 2019
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Haringa, C. (author)The broth in industrial scale fermentors may contain significant gradients in, for example, substrate concentration, dissolved oxygen and shear rates. From the perspective of microbes in this fermentor, these gradients translate to temporal variations in their environment that may affect their metabolic response. As a result, there may be...doctoral thesis 2017
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Yagob Mohamed, T.I. (author)Iron is an essential trace element involved in many processes in the human body. Some disorders like iron deficiency anaemia and haemochromatosis directly result from changes in iron status, while on the other hand iron metabolism changes during illness. Since these adjustments in the iron handling of the body may have consequences for the...doctoral thesis 2016
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Suarez-Mendez, C.A. (author)Production of chemicals via biotechnological routes are becoming rapidly an alternative to oil-based processes. Several microorganisms including yeast, bacteria, fungi and algae can transform feedstocks into high-value molecules at industrial scale. Improvement of the bioprocess performance is a key factor for making this technology economically...doctoral thesis 2015
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Kozak, B.U. (author)Metabolic engineering – the improvement and addition, by genetic modification, of industrially relevant properties of microorganisms with respect to catalysis, transport and regulatory functions – is a well-established method for development of more cost-effective and ‘green’ industrial processes. Rapid depletion of oil reserves and a growing...doctoral thesis 2015
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Oud, B. (author)Reverse engineering is the study of discovering the structure, function and operation of a device or system with the express aim to reconstruct its key functionalities. This principle is applied to many disciplines, from military, through computer engineering, to health, but also in metabolic engineering. In this context, reverse metabolic...doctoral thesis 2013
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- Jamalzadeh, E. (author) doctoral thesis 2013
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Guadalupe Medina, V.G. (author)In its search to decrease the environmental impact of the production of materials and food, and for other socio-economic reasons, mankind has recently taken the first steps into a paradigm shift from a petrochemical-based society to a new, sustainable and to a significant extent bio-based society. In this new scenario, biomass derived from...doctoral thesis 2013
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Huisjes, E.H. (author)The ambition to reduce our current dependence on fossil transportation fuels has driven renewed interest in bioethanol. Pectin-rich feedstocks like sugar beet pulp and citrus peel, which are currently sold as cattle feed, are promising raw materials for the production of bioethanol. This thesis explores the challenges related to the fermentation...doctoral thesis 2013
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Braga da Cruz, A.L. (author)Temperature is an environmental parameter that greatly affects the growth of microorganisms, due to its impact on the activity of all enzymes in the network. This is particularly relevant in habitats where there are large temperature changes, either daily or seasonal. Understanding how organisms have adapted to cope with these temperature-cycles...doctoral thesis 2013
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De Kok, S. (author)Metabolic engineering – the improvement of cellular activities by manipulation of enzymatic, transport and regulatory functions of the cell – has enabled the industrial production of a wide variety of biological molecules from renewable resources. Microbial production of fuels and chemicals thereby provides an alternative to oil-based production...doctoral thesis 2012
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Zelle, R.M. (author)Biotechnological production of chemicals from renewable feedstocks offers a sustainable alternative to petrochemistry. Understanding of the biology of microorganisms and plants is increasing at an unprecedented rate and tools with which these organisms can be engineered for industrial application are becoming ever more powerful. However,...doctoral thesis 2011
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Li, Y. (author)In modern molecular biology, the vast amount of experimental data enables us to obtain more comprehensive understanding of cellular activities, from transcription to metabolism. However, due to the inherent complexity of the cell and the various limitations of the measuring techniques, these data are often noisy and incomplete. Therefore,...doctoral thesis 2010
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