Developing a hands-free video microscope concept for monitoring skin microcirculation in ICU patients

This thesis describes the development of a bedside system concept for monitoring the microcirculation of intensive care patients.<br/><br/>Microcirculation refers to the smallest blood vessels in the body, including capillaries, arterioles, and venules. These tiny blood vessels facilitate the exchange of oxygen, nutrients, and waste products...

Is the Microcirculation the Key in Understanding the Development of Shock After Cardiothoracic Surgery?

Cardiothoracic surgery is a common treatment for cardiovascular diseases. Patients are admitted to the ICU after cardiothoracic surgery for continuous monitoring to prevent or treat postoperative complications as much and as soon as possible. One of these complications is the development of circulatory shock. It is likely caused by one or a...

Improving the Clinical Interpretation of Transcutaneous Carbon Dioxide and Oxygen Measurements in the Neonatal Intensive Care Unit

Introduction: Transcutaneous blood gas monitoring allows for continuous non-invasive evaluation of carbon dioxide and oxygen levels. Its use is limited as its accuracy is dependent on several factors. We aimed to identify the most influential factors to increase usability and aid in the interpretation of transcutaneous blood gas monitoring....

Real-time laser speckle contrast imaging measurement during normothermic machine perfusion in pretransplant kidney assessment

Objectives: Normothermic machine perfusion (NMP) provides a platform for pre-transplant kidney quality assessment that is essential for the use of marginal donor kidneys. Laser speckle contrast imaging (LSCI) presents distinct advantages as a real-time and noncontact imaging technique for measuring microcirculation. In this study, we aimed to...

Sublingual microcirculation in patients with a severe COVID-19 infection and in patients who develop cardiogenic shock after cardiothoracic surgery

Background and aim: The exact pathophysiology of a COVID-19 infection is still not completely understood, which complicates treatment of the disease. In order to clarify the pathophysiologic mechanisms and optimize treatment methods, monitoring of the sublingual microcirculation may be valuable. From studies in septic patients, we know that...

Hydroxyl Ethyl Starch (HES) Preserves Intrarenal Microcirculatory Perfusion Shown by Contrast-Enhanced Ultrasound (Ceus), and Renal Function in a Severe Hemodilution Model in Pigs

Acute normovolemic hemodilution (ANH) is associated with low oxygen carrying capacity of blood and purposed to cause renal injury in perioperative setting. It is best accomplished in a perioperative setting by a colloid such as hydroxyl ethyl starch (HES) due its capacity to fill the vascular compartment and maintain colloidal pressure....

Reproducibility of the Pleth Variability Index in premature infants

The aim was to assess the reproducibility of the Pleth Variability Index (PVI), developed for non-invasive monitoring of peripheral perfusion, in preterm neonates below 32 weeks of gestational age. Three PVI measurements were consecutively performed in stable, comfortable preterm neonates in the first 48 h of life. On each occasion, pulse...

Calibrating Doppler imaging of preterm intracerebral circulation using a microvessel flow phantom

Introduction: Preterm infants are born during critical stages of brain development, in which the adaptive capacity of the fetus to extra-uterine environment is limited. Inadequate brain perfusion has been directly linked to preterm brain damage. Advanced high-frequency ultrasound probes and processing algorithms allow visualization of...