Transfer-free Fabrication and Assessment of Transparent Multilayer CVD Graphene MEAs for in-vitro Optogenetic Studies

Electronic interfaces, particularly microelectrode arrays (MEAs), are crucial for studying electrophysiological processes in the body, with applications ranging from implants to deep brain simulators. In neuroscience, they play a vital role in exploring neuronal cell distribution and behaviour, as well as disorders like epilepsy and Alzheimer’s...

Microelectronic design of a pseudo voltage clamp for a 0.18um CMOS-based mesoscale neural interface for intracellular in-vitro recording and stimulation

The need to understand how the brain works has sparked interest in electrode arrays to record neural signals. Intracellular recordings with nanoelectrodes that penetrate the cell allow better signal quality and additional functions such as voltage clamping to set the neuron's transmembrane voltage. The voltage clamp aims to facilitate the...

Design, Integration and Characterization of Microelectrodes for Heart-On-Chip Applications

The lack of reliable disease models hampers the development of safe and effective drugs for humansas they fail to precisely identify the cardiotoxicity profile of drug compounds. Recent technological advancements have led to the development of the"Organ-On-Chip"(OOC) technology. OOCs are miniaturized micro-engineered devices which aim to...

Oscillator based Analog-to-Digital Converter for Action Potential Readout in Microelectrode Arrays

The functioning of the brain depends on the interplay between a large number of neurons. To understand the information processing in neuronal networks, we need tools to record the electrical activity of cells at high resolution. Microelectrode arrays (MEAs) are predominantly used to measure neuronal activity<br/>at high spatial and temporal...

A 3D microelectrode array to record neural activity at different tissue depths

Measuring neuronal responses along all three spatial dimensions is the next step, beyond the capacity of established 2D microelectrode arrays (MEAs), to record electric activity inside tissues with highly accurate spatial resolution. This research presents silicon-based planar arrays of 3D microelectrodes, whereby each microelectrode supports...

Functional Characterization of Human iPSC-Derived Neural Networks using MEA Systems for in vitro Modeling of Psychiatric Disorders

Psychiatric disorders are associated with major societal, personal issues and comprise 13% of the global burden of disease. They are heritable and present a complex pathophysiology, characterized by hundreds of genetic variants which are cumulated together and provoke a specific psychiatric disorder. Although a considerable progress has been...

Novel microelectrode arrays for in-vitro analysis of neural activity

Microelectrode arrays (MEAs) are extensively used for measuring neural activity in-vitro given their ability to monitor several neurons simultaneously unlike techniques such as patch clamp. However, MEAs still have limitations in acquiring high spatial resolution data due to limited number of channels that can be parallelly scanned, the need for...