Searched for: subject%3A%22Microelectrode%255C+arrays%22
(1 - 13 of 13)
document
León González, Gonzalo (author)
Electronic interfaces, particularly microelectrode arrays (MEAs), are crucial for studying electrophysiological processes in the body, with applications ranging from implants to deep brain simulators. In neuroscience, they play a vital role in exploring neuronal cell distribution and behaviour, as well as disorders like epilepsy and Alzheimer’s...
master thesis 2024
document
Revyn, N. (author), Hu, Michel H.Y. (author), Frimat, Jean-Philippe (author), de Wagenaar, B. (author), van den Maagdenberg, Arn M.J.M. (author), Sarro, Pasqualina M (author), Mastrangeli, Massimo (author)
We present preliminary recordings on chip of three-dimensional (3D) electric neuronal activity from cultures of cortical neurons derived from human-induced pluripotent stem cells (hiPSCs). The recordings were obtained through 3D microelectrode arrays (MEAs) composed of truncated, 90 μm-high Si micropyramids endowed with multiple, electrically...
conference paper 2022
document
del Rivero Cortázar, Aitor (author)
The need to understand how the brain works has sparked interest in electrode arrays to record neural signals. Intracellular recordings with nanoelectrodes that penetrate the cell allow better signal quality and additional functions such as voltage clamping to set the neuron's transmembrane voltage. The voltage clamp aims to facilitate the...
master thesis 2021
document
Shriya Rangaswamy, Shriya (author)
The lack of reliable disease models hampers the development of safe and effective drugs for humansas they fail to precisely identify the cardiotoxicity profile of drug compounds. Recent technological advancements have led to the development of the"Organ-On-Chip"(OOC) technology. OOCs are miniaturized micro-engineered devices which aim to...
master thesis 2021
document
Mastrangeli, Massimo (author), Aydogmus, H. (author), Dostanic, M. (author), Motreuil-Ragot, P.A. (author), Revyn, N. (author), de Wagenaar, B. (author), Dekker, R. (author), Sarro, Pasqualina M (author)
Stemming from the convergence of tissue engineering and microfluidics, organ-on-chip (OoC) technology can reproduce in vivo-like dynamic microphysiological environments for tissues in vitro. The possibility afforded by OoC devices of realistic recapitulation of tissue and organ (patho)physiology may hold the key to bridge the current...
conference paper 2021
document
Baladari, Nikhita (author)
The functioning of the brain depends on the interplay between a large number of neurons. To understand the information processing in neuronal networks, we need tools to record the electrical activity of cells at high resolution. Microelectrode arrays (MEAs) are predominantly used to measure neuronal activity<br/>at high spatial and temporal...
master thesis 2020
document
de Rijk, Tim (author)
Measuring neuronal responses along all three spatial dimensions is the next step, beyond the capacity of established 2D microelectrode arrays (MEAs), to record electric activity inside tissues with highly accurate spatial resolution. This research presents silicon-based planar arrays of 3D microelectrodes, whereby each microelectrode supports...
master thesis 2020
document
Waafi, Affan K. (author), Gaio, N. (author), Quiros Solano, W.F. (author), Dijkstra, Paul (author), Sarro, Pasqualina M (author), Dekker, R. (author)
We present the first Organ-on-Chip equipped with a low-impedance Poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) MicroElectrode Array (MEA). The novel device allows simultaneous mechanical stimulation with a stretchable PDMS membrane and electrical monitoring via the PEDOT:PSS MEA of multiple in vitro cell cultures. The...
journal article 2020
document
Sfakianou, Areti (author)
Psychiatric disorders are associated with major societal, personal issues and comprise 13% of the global burden of disease. They are heritable and present a complex pathophysiology, characterized by hundreds of genetic variants which are cumulated together and provoke a specific psychiatric disorder. Although a considerable progress has been...
master thesis 2019
document
Vyza, Yashwanth (author)
Microelectrode arrays (MEAs) are extensively used for measuring neural activity in-vitro given their ability to monitor several neurons simultaneously unlike techniques such as patch clamp. However, MEAs still have limitations in acquiring high spatial resolution data due to limited number of channels that can be parallelly scanned, the need for...
master thesis 2019
document
Gaio, N. (author)
The cost and the development time of pharamecutical products are often severely affected by the in vitro tests currently employed in pharmaceutical R&amp;D. These assays are often failing to accurately recapitulate diseases and to predict human responses to new medicines. Organ-on-Chip (OOC) devices are designed to result in advanced in vitro...
doctoral thesis 2019
document
Gaio, N. (author), Silvestri, C. (author), van Meer, B.J. (author), Vollebregt, S. (author), Mummery, CL (author), Dekker, R. (author)
Microelectrode arrays (MEAs) are widely used in biological application to locally stimulate and record the electrical activity of living cells. Here, a novel fabrication process for a carbon nanotube (CNT)-based MEA integrated on the backside of a free standing stretchable membrane is reported. The new<br/>process flow overcomes the manually...
journal article 2016
document
Corb, I. (author), Manea, F. (author), Radovan, C. (author), Pop, A. (author), Burtica, G. (author), Malchev, P.G. (author), Picken, S.J. (author), Schoonman, J. (author)
Electrodes based on carbon, i.e., expanded graphite (20%, wt.)-epoxy composite (20EG-Epoxy) and expanded graphite (20%, wt.)-polystyrene composite (20EG-PS) have been prepared, characterized using scanning electron microscopy (SEM) and cyclic voltammetry (CV), and tested as anodic sensors. The electrodes exhibited good mechanical resistance and...
journal article 2007
Searched for: subject%3A%22Microelectrode%255C+arrays%22
(1 - 13 of 13)