Searched for: subject%3A%22Microglia%22
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Sharaf, A.M.S.E. (author), Roos, B. (author), Timmerman, Raissa (author), Kremers, Gert-Jan (author), Bajramovic, Jeffrey John (author), Accardo, A. (author)
Microglia are the resident macrophages of the central nervous system and contribute to maintaining brain’s homeostasis. Current 2D “petri-dish” in vitro cell culturing platforms employed for microglia, are unrepresentative of the softness or topography of native brain tissue. This often contributes to changes in microglial morphology, exhibiting...
journal article 2022
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Kenkhuis, Boyd (author), Somarakis, Antonios (author), Kleindouwel, Lynn R.T. (author), van Roon-Mom, Willeke M.C. (author), Höllt, T. (author), van der Weerd, Louise (author)
Microglia have been identified as key players in Alzheimer's disease pathogenesis, and other neurodegenerative diseases. Iba1, and more specifically TMEM119 and P2RY12 are gaining ground as presumedly more specific microglia markers, but comprehensive characterization of the expression of these three markers individually as well as combined...
journal article 2022
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Roos, Brian (author)
Microglia, the resident macrophages of the central nervous system, are key players in neuroinflammation and neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. These cells represent promising cellular targets for therapeutic intervention, therefore a detailed cellular biological knowledge of microglia is of paramount importance....
master thesis 2021
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Kenkhuis, Boyd (author), Somarakis, Antonios (author), de Haan, Lorraine (author), Dzyubachyk, Oleh (author), Ijsselsteijn, Marieke E. (author), de Miranda, Noel F. C. C. (author), Lelieveldt, B.P.F. (author), Dijkstra, Jouke (author), Van Roon-Mom, Willeke (author), Höllt, T. (author), van der Weerd, Louise (author)
Brain iron accumulation has been found to accelerate disease progression in amyloid-β(Aβ) positive Alzheimer patients, though the mechanism is still unknown. Microglia have been identified as key players in the disease pathogenesis, and are highly reactive cells responding to aberrations such as increased iron levels. Therefore, using...
journal article 2021
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Kuil, Laura E. (author), Oosterhof, Nynke (author), Geurts, S.N. (author), Van Der Linde, Herma C. (author), Meijering, H.W. (author), Van Ham, Tjakko J. (author)
Microglia are brain-resident macrophages, which have specialized functions important in brain development and in disease. They colonize the brain in early embryonic stages, but few factors that drive the migration of yolk sac macrophages (YSMs) into the embryonic brain, or regulate their acquisition of specialized properties, are currently...
journal article 2019
Searched for: subject%3A%22Microglia%22
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