Searched for: subject%3A%22Mouse%22
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Duroyon, Marin (author)
Acoustic side-channel attacks (SCAs) use audio produced by a system to bypass traditional security measures to extract sensitive information. Human interface devices, such as keyboards, have been the focus of such attacks, however, computer mice are input devices that are currently in a research gap. This paper explores the security risks the...
master thesis 2024
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Generowicz, Bastian S. (author), Dijkhuizen, Stephanie (author), Bosman, Laurens W.J. (author), De Zeeuw, Chris I. (author), Koekkoek, Sebastiaan K.E. (author), Kruizinga, P. (author)
Functional ultrasound (fUS) using a 1-D-array transducer normally is insufficient to capture volumetric functional activity due to being restricted to imaging a single brain slice at a time. Typically, for volumetric fUS, functional recordings are repeated many times as the transducer is moved to a new location after each recording, resulting...
journal article 2023
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Generowicz, Bastian S. (author), Dijkhuizen, Stephanie (author), De Zeeuw, Chris I. (author), Koekkoek, Sebastiaan K.E. (author), Kruizinga, P. (author)
Volumetric 3-D Doppler ultrasound imaging can be used to investigate large scale blood dynamics outside of the limited view that conventional 2-D power Doppler images (PDIs) provide. To create 3-D PDIs, 2-D-matrix array transducers can be used to insonify a large volume for every transmission; however, these matrices suffer from low...
journal article 2023
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Erol, A. (author), Generowicz, Bastian (author), Kruizinga, P. (author), Hunyadi, Borbala (author)
Functional ultrasound (fUS) is an emerging neuroimaging modality that indirectly measures neural activity by detecting fluctuations in local blood dynamics. fUS acquisitions typically rely on the use of a 1D array transducer, which records hemodynamic activity in a single plane. A new technique named swept-3D fUS imaging obtains a full 3D...
conference paper 2023
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Georgiadis, Marios (author), Menzel, Miriam (author), Reuter, Jan A. (author), Born, Donald E. (author), Kovacevich, Sophie R. (author), Alvarez, Dario (author), Taghavi, Hossein Moein (author), Schroeter, Aileen (author), Rudin, Markus (author)
Myelinated axons (nerve fibers) efficiently transmit signals throughout the brain via action potentials. Multiple methods that are sensitive to axon orientations, from microscopy to magnetic resonance imaging, aim to reconstruct the brain's structural connectome. As billions of nerve fibers traverse the brain with various possible geometries...
journal article 2023
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Erol, A. (author), Soloukey, Chagajeg (author), Generowicz, Bastian (author), van Dorp, Nikki (author), Koekkoek, Sebastiaan (author), Kruizinga, P. (author), Hunyadi, Borbala (author)
Functional ultrasound (fUS) indirectly measures brain activity by detecting changes in cerebral blood volume following neural activation. Conventional approaches model such functional neuroimaging data as the convolution between an impulse response, known as the hemodynamic response function (HRF), and a binarized representation of the input...
journal article 2022
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van Gemert, Y. (author), Kozijn, A. E. (author), Pouwer, M. G. (author), Kruisbergen, N. N.L. (author), van den Bosch, M. H.J. (author), Blom, A.B. (author), Pieterman, E. J. (author), Weinans, Harrie (author), Stoop, R. (author), Princen, H. M.G. (author), van Lent, P. L.E.M. (author)
Objective: High systemic cholesterol levels have been associated with osteoarthritis (OA) development. Therefore, cholesterol lowering by statins has been suggested as a potential treatment for OA. We investigated whether therapeutic high-intensive cholesterol-lowering attenuated OA development in dyslipidemic APOE∗3Leiden.CETP mice. Methods:...
journal article 2021
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Suresh Subramonian, Jishnu (author)
The most simplistic acts in nature can be incredibly complex to replicate. Among which, insects in general, are profound micro-machines with evolution as the backbone for their most optimized features. This study focuses on developing an efficient sensing and processing strategy for autonomous flight maneuvers in Atalanta, a bio-inspired robotic...
master thesis 2020
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Klarenbeek, Sjoerd (author), Doornebal, Chris W. (author), Kas, Sjors M. (author), Bonzanni, Nicola (author), Bhin, Jinhyuk (author), Braumuller, Tanya M. (author), van der Heijden, Ingrid (author), de Bruijn, Roebi (author), Wessels, L.F.A. (author)
Effective treatment of invasive lobular carcinoma (ILC) of the breast is hampered by late detection, invasive growth, distant metastasis, and poor response to chemotherapy. Phosphoinositide 3-kinase (PI3K) signaling, one of the major druggable oncogenic signaling networks, is frequently activated in ILC. We investigated treatment response and...
journal article 2020
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de Groot, Andres (author), van den Boom, Bastijn Jg (author), van Genderen, Romano M. (author), Coppens, Joris (author), van Veldhuijzen, John (author), Bos, Joop (author), Hoedemaker, Hugo (author), Negrello, M.J.F. (author), Willuhn, Ingo (author), De Zeeuw, Chris I. (author), Hoogland, Tycho M. (author)
Miniaturized fluorescence microscopes (miniscopes) have been instrumental to monitor neural signals during unrestrained behavior and their open-source versions have made them affordable. Often, the footprint and weight of open-source miniscopes is sacrificed for added functionality. Here, we present NINscope: a light-weight miniscope with a...
journal article 2020
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Betting, J.L.F. (author), Romano, Vincenzo (author), Al-Ars, Z. (author), Bosman, L.W.J. (author), Strydis, C. (author), De Zeeuw, Chris I. (author)
Rodents engage in active touch using their facial whiskers: they explore their environment by making rapid back-and-forth movements. The fast nature of whisker movements, during which whiskers often cross each other, makes it notoriously difficult to track individual whiskers of the intact whisker field. We present here a novel algorithm,...
journal article 2020
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Groß, C. (author), de Ridder, D. (author), Reinders, M.J.T. (author)
Background: Predicting the deleteriousness of observed genomic variants has taken a step forward with the introduction of the Combined Annotation Dependent Depletion (CADD) approach, which trains a classifier on the wealth of available human genomic information. This raises the question whether it can be done with less data for non-human...
journal article 2018
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De Ruiter, J. R. (author), Wessels, L.F.A. (author), Jonkers, J. (author)
Cancer is a complex disease in which cells progressively accumulate mutations disrupting their cellular processes. A fraction of these mutations drive tumourigenesis by affecting oncogenes or tumour suppressor genes, but many mutations are passengers with no clear contribution to tumour development. The advancement of DNA and RNA sequencing...
review 2018
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Redeker, Anke (author), Remmerswaal, Ester B.M. (author), van der Gracht, Esmé T.I. (author), Welten, Suzanne P.M. (author), Höllt, T. (author), Koning, Frits (author), Cicin-Sain, Luka (author), Nikolich-Žugich, Janko (author), ten Berge, Ineke J.M. (author), van Lier, René A. W. (author), van Unen, Vincent (author), Arens, Ramon (author)
The relationship between human cytomegalovirus (HCMV) infections and accelerated immune senescence is controversial. Whereas some studies reported a CMV-associated impaired capacity to control heterologous infections at old age, other studies could not confirm this. We hypothesized that these discrepancies might relate to the variability in the...
journal article 2018
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Mulder, Inge A. (author), Khmelinskii, Artem (author), Dzyubachyk, Oleh (author), de Jong, Sebastiaan (author), Rieff, Nathalie (author), Wermer, Marieke J.H. (author), Hoehn, Mathias (author), Lelieveldt, B.P.F. (author), van den Maagdenberg, Arn M.J.M. (author)
Magnetic resonance imaging (MRI) has become increasingly important in ischemic stroke experiments in mice, especially because it enables longitudinal studies. Still, quantitative analysis of MRI data remains challenging mainly because segmentation of mouse brain lesions in MRI data heavily relies on time-consuming manual tracing and...
journal article 2017
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Riool, M. (author), Dirks, A. J. (author), Jaspers, V. (author), Loontjens, T. J.A. (author), van der Loos, C. M. (author), Florquin, S. (author), Apachitei, I. (author), Rijk, L. N.D. (author), Keul, H. A. (author), Zaat, S.A.J. (author)
Prevention of biomaterial-associated infections (BAI) remains a challenging problem, in particular due to the increased risk of resistance development with the current antibiotic-based strategies. Metallic orthopaedic devices, such as non-cemented implants, are often inserted under high mechanical stress. These non-cemented implants cannot be...
journal article 2017
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Mulder, Inge A. (author), Khmelinskii, Artem (author), Dzyubachyk, Oleh (author), De Jong, Sebastiaan (author), Wermer, Marieke J.H. (author), Hoehn, Mathias (author), Lelieveldt, B.P.F. (author), van den Maagdenberg, Arn M.J.M. (author)
In this data report we make available to the community a highly variable longitudinal MRI mouse brain data set of ischemic lesion after transient middle cerebral artery occlusion (tMCAo). Together with the provided semi-automated and automated segmentations, these data can be used to further improve the method proposed by Mulder et al. (2017)...
journal article 2017
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Hammelrath, Luam (author), Škokić, Siniša (author), Khmelinskii, Artem (author), Hess, Andreas (author), van der Knaap, Noortje (author), Staring, M. (author), Lelieveldt, B.P.F. (author), Wiedermann, Dirk (author), Hoehn, Mathias (author)
With the wide access to studies of selected gene expressions in transgenic animals,mice have become the dominant species as cerebral diseasemodels. Many of these studies are performed on animals of not more than eight weeks, declared as adult animals. Based on the earlier reports that full brain maturation requires at least three months in rats,...
journal article 2016
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Mok, G. (author)
master thesis 2015
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Hussong, J. (author), Lindken, R. (author), Faulhammer, P. (author), Noreikat, K. (author), Sharp, K.V. (author), Kummer, W. (author), Westerweel, J. (author)
To date, there is only a fragmentary understanding of the fundamental mechanisms of airway mucociliary transport. Application of the latest measurement techniques can aid in deciphering the complex interplay between ciliary beat and airway surface liquid (ASL) transport. In the present study, direct, quasi-simultaneous measurements of the cilia...
journal article 2013
Searched for: subject%3A%22Mouse%22
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