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Lee, Won Yong (author), Wen, C. (author), Pham, N.H. (author), Khaksaran, Mohammad Hadi (author), Lee, S. (author), Zhang, Shi Li (author)Tracing fast nanopore-translocating analytes requires a high-frequency measurement system that warrants a temporal resolution better than 1 µs. This constraint may practically shift the challenge from increasing the sampling bandwidth to dealing with the rapidly growing noise with frequencies typically above 10 kHz, potentially making it...journal article 2024
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Klughammer, N. (author)In this thesis, we have introduced palladium zero-mode waveguides (Pd ZMWs) as a valuable tool for biophysics research and have showcased several applications thereof. We started by using them as single-molecule sensors for free translocations of fluorophores, proteins, and voltage-driven translocations of DNA. By studying salt-gradient driven...doctoral thesis 2023
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Lei, Xin (author), Zhang, Jiayan (author), Hong, H. (author), Wei, Jiangtao (author), Liu, Zewen (author), Jiang, Lei (author)Solid-state nanopores attract widespread interest, owning to outstanding robustness, extensive material availability, as well as capability for flexible manufacturing. Bioinspired solid-state nanopores further emerge as potential nanofluidic diodes for mimicking the rectification progress of unidirectional ionic transport in biological K<sup>...journal article 2023
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Lemaalem, Mohammed (author), Khossossi, N. (author), Bouder, Gaelle (author), Dey, P. (author), Carbonnière, Philippe (author)All-solid electrolytes could lead to a technological breakthrough in the performance of all-solid-state batteries when combined with a lithium-metal anode. However, the use of a lithium-metal anode presents several challenges, such as dendrite growth, interface electrochemical stability, formation and propagation of cracks, and delamination...journal article 2023
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Petrov, K.V. (author), Santoso, A. (author), Ryzhkov, Ilya I. (author), Vermaas, D.A. (author)Polymeric ion-exchange membranes (IEMs) are key to many electrochemical processes, but their intrinsic selectivity limitations restrict scale-up possibilities. Nanofluidic IEMs, based on inorganic rigid materials and charged nanopores, offer a promising alternative. We present design criteria for selective nanofluidic membranes. We used...journal article 2023
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Vasileiadis, A. (author), Li, Yuqi (author), Lu, Yaxiang (author), Hu, Yong Sheng (author), Wagemaker, M. (author)There are several questions and controversies regarding the Na storage mechanism in hard carbon. This springs from the difficulty of probing the vast diversity of possible configurational environments for Na storage, including surface and defect sites, edges, pores, and intercalation morphologies. In the effort to explain the observed voltage...journal article 2023
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Shariati, Vahid (author), Roohi, Ehsan (author), Ebrahimi, Amin (author)The direct simulation Monte Carlo (DSMC) method, which is a probabilistic particle-based gas kinetic simulation approach, is employed in the present work to describe the physics of rarefied gas flow in super nanoporous materials (also known as mesoporous). The simulations are performed for different material porosities (0.5≤ϕ≤0.9), Knudsen...journal article 2023
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Dematties, Dario (author), Wen, C. (author), Zhang, Shi Li (author)Pulse-like signals are ubiquitous in the field of single molecule analysis, e.g., electrical or optical pulses caused by analyte translocations in nanopores. The primary challenge in processing pulse-like signals is to capture the pulses in noisy backgrounds, but current methods are subjectively based on a user-defined threshold for pulse...journal article 2022
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Lei, Xin (author), Zhang, Jiayan (author), Hong, H. (author), Yuan, Zhishan (author), Liu, Zewen (author)Nanopores have attracted widespread attention in DNA sequencing and protein or biomarker detection, owning to the single-molecule-scale detection accuracy. Despite the most use of naturally biological nanopores before, solid-state nanopores are widely developed with strong robustness, controllable sizes and geometries, a wide range of...review 2022
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Wen, C. (author), Bertosin, E. (author), Shi, X. (author), Dekker, C. (author), Schmid, Sonja (author)Nanopores are versatile single-molecule sensors offering a simple label-free readout with great sensitivity. We recently introduced the nanopore electro-osmotic trap (NEOtrap) which can trap and sense single unmodified proteins for long times. The trapping is achieved by the electro-osmotic flow (EOF) generated from a DNA-origami sphere...journal article 2022
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Fernando, Niranjala (author), Veldhuizen, H.V. (author), Nagai, Atsushi (author), van der Zwaag, S. (author), Abdelkader, Amor (author)Nanoporous polymers are becoming increasingly interesting materials for electrochemical applications, as their large surface areas with redox-active sites allow efficient adsorption and diffusion of ions. However, their limited electrical conductivity remains a major obstacle in practical applications. The conventional approach that alleviates...journal article 2022
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Ji, X. (author), van Ginkel, H.J. (author), Hu, D. (author), Schmidt-Ott, A. (author), van Zeijl, H.W. (author), Vollebregt, S. (author), Zhang, Kouchi (author)Advances in semiconductor device manufacturing technologies are enabled by the development and application of novel materials. Especially one class of materials, nanoporous films, became building blocks for a broad range of applications, such as gas sensors and interconnects. Therefore, a versatile fabrication technology is needed to...conference paper 2022
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Fragasso, A. (author), de Vries, Hendrik W. (author), Andersson, John (author), van der Sluis, E.O. (author), van der Giessen, Erik (author), Onck, Patrick R. (author), Dekker, C. (author)Nuclear pore complexes (NPCs) regulate all molecular transport between the nucleus and the cytoplasm in eukaryotic cells. Intrinsically disordered Phe-Gly nucleoporins (FG-Nups) line the central conduit of NPCs to impart a selective barrier where large proteins are excluded unless bound to a transport receptor (karyopherin; Kap). Here, we...journal article 2022
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Weijers, M.J. (author), Karanth, P. (author), Ganapathy, S. (author), Mulder, F.M. (author)Nanostructured solid composite electrolyte or nano-SCE, which is composed of an ionic liquid, nanoporous silica, and residuals of immobilized precursor components, shows promising synergistic properties. The ionic conductivity of nano-SCE is in the range of 2–5 mS cm<sup>−1</sup>, which exceeds the bulk ionic liquid conductivity at ambient...journal article 2022
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Fragasso, A. (author)At first glance nanopores may appear simple, almost intuitive, to understand given that they are, quite literally, ‘just’ very small pores in a membrane. In fact, one may even wonder why at all we need trained scientists to study such seemingly simple entities. The short answer is that nanopores, as the word suggests, are nanoscale entities and,...doctoral thesis 2021
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Yang, W.W.W. (author)We start this thesis by exploring the question whether there is more to be done with solid-state nanopores, given the success of nanopores for DNA sequencing applications.doctoral thesis 2021
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Fragasso, A. (author), De Franceschi, N. (author), Stömmer, Pierre (author), van der Sluis, E.O. (author), Dietz, Hendrik (author), Dekker, C. (author)Molecular traffic across lipid membranes is a vital process in cell biology that involves specialized biological pores with a great variety of pore diameters, from fractions of a nanometer to >30 nm. Creating artificial membrane pores covering similar size and complexity will aid the understanding of transmembrane molecular transport in...journal article 2021
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Kurupath, Vishnu Prasad (author), Kannam, Sridhar Kumar (author), Hartkamp, Remco (author), Sathian, Sarith P. (author)Biological nanopores such as aquaporins combine the opposing functions of high water permeation and total ion exclusion in part by the virtue of their hourglass shape. Here, we perform molecular dynamics simulations to examine water and ion conduction through hourglass shaped nanopores created from carbon nanotubes (CNTs) of chirality (6,6), ...journal article 2021
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Loeff, L. (author), Kerssemakers, J.W.J. (author), Joo, C. (author), Dekker, C. (author)Single-molecule techniques allow the visualization of the molecular dynamics of nucleic acids and proteins with high spatiotemporal resolution. Valuable kinetic information of biomolecules can be obtained when the discrete states within single-molecule time trajectories are determined. Here, we present a fast, automated, and bias-free step...journal article 2021
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Pouran, Behdad (author), Raoof, Amir (author), de Winter, D. A.Matthijs (author), Arbabi, V. (author), Bleys, Ronald L.A.W. (author), Beekman, F.J. (author), Zadpoor, A.A. (author), Malda, Jos (author), Weinans, Harrie (author)Recent insights suggest that the osteochondral interface plays a central role in maintaining healthy articulating joints. Uncovering the underlying transport mechanisms is key to the understanding of the cross-talk between articular cartilage and subchondral bone. Here, we describe the mechanisms that facilitate transport at the osteochondral...journal article 2021