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Zwartveld, Stef (author)Subjective tinnitus is a sensation of sound without an external source. There is no clear understanding of the cause and pathology of tinnitus.<br/><br/>Literature suggests a combination of deafferentation of the tonotopic map , the Bayesian brain model, and the triple mode network, creating one combined hypothesis for tinnitus pathology. Based...master thesis 2024
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Kawasaki, S. (author)CMUTs (Capacitive Micromachined Ultrasonic Transducers) are causing a technological revolution. Research over the last decade showed that CMUTs can sufficiently replace traditional ultrasound technology based on the bulk PZT, along with other benefits such as lower assembly cost, broader bandwidth and monolithic integration capability with ASICs...doctoral thesis 2024
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Wemelsfelder, Tom (author)In recent years, many therapeutic applications for medical ultrasound have arisen, such as ablation of tumors, breaking up kidney stones, and neuromodulation. To localize the target area, often ultrasound imaging methods are used. Conventionally, a different transducer array is used for imaging and therapeutic applications because of their...master thesis 2024
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Chen, Hsukang (author)To achieve greater specificity in neurostimulation, bidirectional neural interfaces are required to verify the recorded neural response after stimulation. The specific neural interface targeted in this thesis is the epiretinal implant. Due to the heterogeneity of the retinal ganglion cells (RGCs), high-fidelity vision is only possible when all...master thesis 2024
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- Woerdman, Hidde (author) master thesis 2023
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Kluba, M.M. (author)The progress in the field of neurostimulation is impressive, both from a technical as well as from a therapeutic point of view. Nowadays, the electrical stimulation of the nervous system can be used to induce or suppress muscle responses. Additionally, it can also influence hearing, vision, immune system response, pain perception, and even...doctoral thesis 2022
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Coolen, R.J.J. (author), Emmer, K.M. (author), Spantidea, P.I. (author), Asselt, E. van (author), Scheepe, J.R. (author), Serdijn, W.A. (author), Blok, B.F.M. (author)The first two objectives were to establish which stimulation parameters of kilohertz frequency alternating current (KHFAC) neuromodulation influence the effectiveness of pudendal nerve block and its safety. The third aim was to determine whether KHFAC neuromodulation of the pudendal nerve can relax the pelvic musculature, including the anal...journal article 2022
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Brash, Rohan (author)Implantable epiretinal prostheses aim to restore visual capability for patients suffering from diseases such as Macular Degeneration and Retinitis Pigmentosa by bypassing damaged photoreceptors and electrically exciting Retinal Ganglion Cells (RGCs) directly. Next-generation devices will require single-cell resolution, and bidirectional...master thesis 2021
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Verzijl, Hubald (author)<i>Neuropathic pain</i> (NP) affects approximately seven to ten percent of the general population. Seventeen percent of NP patients scored their life as “worse than death”. A myriad of causes may underlie NP, such as stroke or spinal cord injury. Also, damage or disease of the <i>peripheral nervous system</i> (PNS) may result in NP. One of the...master thesis 2021
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Veselka, David (author)Implantable Medical Devices (IMDs) are deployed in patients to treat a range of medical conditions. Technological advancements have enabled manufacturers to fit IMDs with specialized hardware that accelerates compute-intensive medical therapies next to a software-run host processor. However, mostly hardware acceleration is found in the form of...master thesis 2021
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Dijkema, Eric (author)Ultrasound (US) neurostimulation, the non-pharmacological, reversible excitation or inhibition of the nervous system using ultrasonic waves, is emerging as a high interest topic in neurostimulation research. In the current project, an attempt was made to demonstrate US neuromodulation in a Lumbricus Terrestris model of evoked compound action...master thesis 2020
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Varkevisser, Francesc (author)Development of a visual prosthesis has the potential to help millions of patients with visual impairment around the world. One approach of visual prostheses is intracortical stimulation, where electrodes penetrating the visual cortex are used to create small light dots in the patients visual field. Said therapy requires an implantable...master thesis 2020
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Barbon-Pedrina, Alessandro (author)Approximately 15-20% of theworld population is aected by tinnitus, a hearing condition associated with phantomsound perception. A large number of suerers experience a severe level of tinnitus and they are not ableto conduct a normal life because they develop insomnia, depression, and distress.Extensive research has been made to study its...master thesis 2020
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Zufiria Gerbolés, Pedro (author)Neurostimulation is a common medical treatment modality used to treat neurological disorders. It applies electrical pulses to revert and prevent undesired neural behavior or to create desired neural behavior. The required specificity of said stimulation treatments is oftentimes achieved by implanting the neurostimulator close to the target area....master thesis 2020
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Hosman, Tim (author)Electronic implants are becoming a valuable tool to explore and regulate neural activity, potentially overcoming neural disabilities that are still incurable. On the one hand, neural recording can provide tremendous insight into the neural system and the sometimes accompanied neural diseases. On the other hand, neural stimulation is necessary to...master thesis 2020
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Guan, R. (author), Zufiria, Pedro G. (author), Giagka, Vasiliki (author), Serdijn, W.A. (author)This paper presents the main circuit design considerations for power-efficient and safe implantable electrical neurostimulators. Related to medical applications, low-frequency (LF) stimulation for generating new action potentials and kilohertz-frequency alternating current (KHFAC) for blocking unwanted neural activity are introduced,...conference paper 2020
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Prasanth, Hari (author)In a recent first-in-human clinical study, a therapy based on targeted epidural electrical stimulation together with body weight support has been validated to restore voluntary locomotion in chronically paralyzed subjects with Spinal Cord Injury (SCI). However, the system is currently open-loop controlled, meaning that the stimulation pattern...master thesis 2019
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Tacchetti, Lucia (author)Neurostimulators have been developed over the past few decades to treat various diseases, such as Parkinson’s disease, chronic pain, epilepsy, migraine and bladder dysfunction. One of the major design challenges is the selection of a powering method that could supply mW power levels to miniaturized implanted devices. Among several methods,...master thesis 2018
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Tacchetti, Lucia (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)This paper presents the design of a neurostimulator performing biphasic ultra-high-frequency electrical stimulation while being driven from ultrasound energy. Unlike conventional constant current or constant voltage stimulators or state-of-the-art ultra-high-frequency stimulators, the system does not convert the input AC signal into regulated...conference paper 2018
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Van Dongen, M.N. (author), Serdijn, W.A. (author)Due to their DC-blocking characteristic, coupling capacitors are widely used to prevent potentially harmful charge buildup at the electrode–tissue interface. Although the capacitors can be an effective safety measure, it often seems overlooked that coupling capacitors actually introduce an offset voltage over the electrode–tissue interface as...journal article 2015