Towards Continuous Monitoring of Volatile Organic Compounds in the Gastrointestinal Tract

Much like wearable devices today, ingestible devices have emerged as a promising platform for continuous health monitoring, and potentially even intervention. Recent research has demonstrated the feasibility of ingestible devices with a retention mechanism, enabling them to remain in the stomach for weeks. Equipping these devices with sensors...

Lipase-Catalysed Enzymatic Kinetic Resolution of Aromatic Morita-Baylis-Hillman Derivatives by Hydrolysis and Transesterification

Acylated Morita-Baylis-Hillman (MBH) adducts were synthesised and subjected to enzymatic kinetic resolution (EKR) by hydrolysis employing various lipase enzymes: from P. fluorescens, P. cepacia (PCL), C. antarctica A (CAL−A), C. antarctica B (CAL−B) and Novozyme 435. In a number of instances enantiopure Morita-Baylis-Hillman acetates or...

Development of a Thin Layer Chromatography method to determine the radiolabeling stability of PCL-PEO micelles radiolabeled with ¹⁷⁷Lu

Polymeric micelles have a promising future in the treatment of cancer patients, and particularly as carriers in chemotherapy. The effectiveness of the micelles can be determined when their fate in vivo is known. Radiolabeling the micelles with diagnostic radionuclides allows for determination of their biodistribution and pharmacokinetics using...

Ionizing Radiation-Induced Release from Poly(ϵ-caprolactone- b-ethylene glycol) Micelles

Polymeric micelles, due to their easy preparation and versatile properties, have been widely applied as one of the most popular carriers for chemotherapeutic agents. Such micelles primarily prevent the leakage of drugs during transportation and thus protect healthy tissue. Controlled drug release, which releases the drugs at the site of...

Design of a 3D printed prosthetic socket that accommodates pediatric growth

Inability to adapt to growth is a problem in the field of pediatric prostheses. Current prostheses do not adapt to the normal growth of children’s limbs and require constant visits to health care providers for adjustment or replacement. To solve this issue a new socket was designed making use of auxetic metamaterials. The residual limb of the...

Antenna Array Signal Processing for Multistatic Radar Systems

The introductions of Digital Beam Forming (DBF), original signal exploitation and waveform multiplexing techniques have led to the design of novel radar concepts. Passive Coherent Locator (PCL) and Multiple-Input Multiple-Output (MIMO) sensors are two examples of innovative approaches. Beside the inherent benefits of this class of sensors,...

Cilia-driven particle and fluid transport over mucus-free mice tracheae

To date, there is only a fragmentary understanding of the fundamental mechanisms of airway mucociliary transport. Application of the latest measurement techniques can aid in deciphering the complex interplay between ciliary beat and airway surface liquid (ASL) transport. In the present study, direct, quasi-simultaneous measurements of the cilia...