Searched for: subject%3A%22PDMS%22
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Tjokro, Kristie (author)
In microfluidics, typical laboratory processes can be condensed to a miniature device. This reduces analysis time and required volumes of samples and reagents, increases mobility and flexibility, and is cost effective. In this work, the environmental impacts of three microfluidic devices for glucose detection are assessed using a comparative...
master thesis 2023
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Blomme, Arthur (author)
Stratospheric Aerosol Injection (SAI) is a geoengineering method to mitigate the effects of increased greenhouse gas concentrations in the Earth’s atmosphere, and to prevent further global warming. SAI does not reverse climate change, it merely counteracts its symptoms by offsetting the radiative forcing of greenhouse gases, and it should be...
master thesis 2023
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Savundranayagam, Reka (author)
In vitro neuromodulation studies play a crucial role in understanding the underlying interaction mechanisms between cells and ultrasound, which is important in the development of new therapies for various neurological disorders. Acoustic focusing, the ability to focus ultrasound at a specific focal length with high spatial resolution, provides a...
master thesis 2023
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Wu, Yantong (author)
This thesis aims to solve the problems and fabricate fully inkjet-printed dielectric elastomer actuators with silver electrodes and a PDMS middle layer. First, a conductive silver electrode is printed on a coated PET substrate, followed by a printing of the dielectric elastomer middle layer to cover the bottom electrode. Then, the top silver...
master thesis 2022
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Schoonhoven, Jilian (author)
The current standard for organ-on-chip substrate materials is polydimethylsiloxane (PDMS). PDMS has many beneficial properties such as biocompatibility, transparency, elasticity, and easy prototyping. The main disadvantages of PDMS are its hydrophobicity (reducing cell attachment and cell proliferation), quick hydrophobic recovery (within a few...
master thesis 2022
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Elschot, Sanne (author)
Dielectric elastomer actuators (DEAs) are a type of soft actuators that consist of a dielectric elastomer membrane, covered with an electrode on the top and the bottom. When applying a potential, the opposite charges on the electrodes induce an electrostatic force which squeezes the elastomer, causing it to expand. This expansion can be used as...
master thesis 2021
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Aalbers, Sarah (author)
The Organ on Chip (OoC) market is fast-growing and has the promise to drastically reduce the cost of developing drugs and the need for animal testing. However, the growth could be obstructed by the difficulties of scaling up production of developed prototypes. Most OoC prototypes are not suited for mass production because of the material used,...
master thesis 2021
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Zhang, Chuqian (author)
Cell behavior in vitro can be regulated by mechanical stimulation. Cytostretch is an Organ-on-Chip (OOC) platform that allows cyclic stretching tissue in culture. Its pneumatic actuation can hinder it from microfluidic systems integration. A dielectric elastomer actuator (DEA) was developed and fabricated in this thesis for Cytostretch as an...
master thesis 2019
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Kootte, Bart (author)
Organ-on-chip (OOC) devices are micro-engineered three-dimensional (3D) biomimetic systems that can be used to create in vitro models of human tissue. They provide an alternative for conventional cell culture tools in pharmaceutical R&D. Moreover, these devices can contribute in research focused on understanding complex disease processes....
master thesis 2019
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Sinha, Rajarshi (author)
Drug development is an entire area of research that partly exploits the developments from biomedical research. Understanding the diseases that affect humanity fatally is critical to our existence. Researchers have studied various molecules and genetic compounds that are responsible for the proliferation of these diseases in the human body. For...
master thesis 2018
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Tio, Kimberly (author)
Administration of drugs can help in the recovery of the brain for example after a stroke. There are many available delivery routes such as intravenous injection or local injection in the brain. Whereas, the former encounters problems with systemic side effects, the latter requires multiple invasive brain surgery. Local drug administration could...
master thesis 2018
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Muhammad Hanif Nadhif, Hanif (author)
The use of conventional biological assay tools, such as Petri dish, has hindered the drug discovery studies ineffective and time-consuming. To cope with this problem, organ-on-chip (OOC) devices have been developed. Modeling organ functionality, topography, and pathology, OOC devices are expected to pave the way the drug discovery processes....
master thesis 2018
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Bagani, Rishab (author)
master thesis 2017
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Shen, Y. (author)
A new method of flexible interposer with vertically aligned carbon nanotube (CNT) embedded in polymer is proposed in this thesis. Interposer, working as electrical routing between different sockets or connections, is being used for spreading connections and rerouting in packaging technology nowadays. With the rapid growing application of...
master thesis 2015
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Shen, Y. (author)
A new method of flexible interposer with vertically aligned carbon nanotube (CNT) embedded in polymer is proposed in this thesis. Interposer, working as electrical routing between different sockets or connections, is being used for spreading connections and rerouting in packaging technology nowadays. With the rapidly growing application of...
master thesis 2015
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Schiltkamp, S.H. (author)
The aim of this thesis is to make clear what the possibilities are towards the implementation of Product Data Management (PDM) in combination with CAD/CAM software in the shipbuilding industry. Even though in many industries there is already an extensive PDM integration in combination with CAD/CAM software, the shipbuilding industry is in its...
master thesis 2015
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Gaio, N. (author)
Over the last few years the need of new alternatives to traditional disease modelling, drug screening and toxicity tests has boosted the development of a new class of devices called Organ on Chip. These usually consist in a substrate or a well in which cells are cultured with the aim of differentiating them in a particular tissue lineage. With...
master thesis 2015
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Rosas Escobar, J.M. (author)
Organs on chips are a novel set of devices whose aim is to mimic cellular in-vivo conditions of the human physiology within a microchip. The need of reliable disease models, particularly for the development of pharmaceutical drugs, has drawn increased attention as the current widespread models; static cell cultures and animal tests, have proven...
master thesis 2014
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Agrawal, S. (author)
An organ-on-chip device, called Cytostretch (Philips NV), that is capable of mechanically stimulating cultured cells, is the subject of this study. The device comprises a microthin PolyDiMethylSiloxane membrane that is highly elastic, on which titanium nitride electrodes have been embedded. Its utility is projected in cardiac research to emulate...
master thesis 2014
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Van Meer, B.J. (author)
In the near future, human cell based Organ-on-Chip models are likely to replace animal experimentation during the development of new drugs. Not only is animal testing associated with ethical issues, but human cell based models can also give a more accurate representation of the human physiology, resulting in more reliable results of drug...
master thesis 2014
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