Searched for: subject%3A%22Parkinson%2527s%255C+disease%22
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Ponsioen, Stijn (author)
In the dynamic realm of medical technology, innovation to improve the lives of those with chronic conditions like Parkinson's Disease (PD) is paramount. This graduation report represents the culmination of a project aiming to address prevalent symptoms in individuals with PD.</p> <p class="MsoNormal">Client and Objective:</p...
master thesis 2024
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Zwinkels, Anouk (author)
<b>Introduction</b>: Deep brain stimulation (DBS) is an important therapeutic option for various neurological diseases. For certain indications the optimal target cannot be identified on structural magnetic resonance imaging (MRI), but can be visualized with tractography. A recent improvement for clinical practice is the probabilistic...
master thesis 2023
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Muller, Marjolein (author)
Introduction: Over the past two decades deep brain stimulation (DBS) has emerged as an important therapeutic option for Parkinson’s disease (PD). However, the current DBS programming method, monopolar review (MPR), is time-consuming, requires highly trained personnel and causes discomfort for patients. This study aimed to predict the optimal...
master thesis 2023
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Koning, Marilotte (author)
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor function loss and potential mental and behavioral changes. The identification of biomarkers in the gut microbiota of PD patients can significantly aid in fast and accurate diagnosis. This study investigates the application of machine learning (ML) models, including...
bachelor thesis 2023
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De Reus, Bob (author)
People who suffer from tremor, experience uncontrollable, involuntary movements. Depending on the underlaying cause, these movements occur during rest, or simultaneous with voluntary movements. <br/>STIL is a YES!Delft based, med-tech startup that is developing a non-invasive, anti-tremor orthosis that helps people with tremors in their upper...
master thesis 2023
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Oosterwegel, Max J. (author), Krijthe, J.H. (author), den Brok, Melina G.H.E. (author), van den Heuvel, Lieneke (author), Richard, Edo (author), Heskes, Tom (author), Bloem, Bastiaan R. (author), Evers, Luc J.W. (author)
Background: Currently available treatment options for Parkinson's disease are symptomatic and do not alter the course of the disease. Recent studies have raised the possibility that cardiovascular risk management may slow the progression of the disease. Objectives: We estimated the effect of baseline cardiovascular risk factors on the...
journal article 2023
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den Hertog, Koen (author)
Parkinson’s Disease is a neurodegenerative disease that has a decline in motor behaviour as one of its main symptoms. This decline is currently monitored using subjective measures, such as questionnaires and clinical observations. More detailed and objective tracking of this decline can improve treatment of the disease and allow for earlier...
master thesis 2022
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Hulst, Naomi (author)
Parkinson’s Disease (PD) is the fastest growing neurodegenerative disease, currently affecting two to three percent of the population over 65. Studying functional connectivity (FC) in PD patients may provide new insights into how the disease alters brain organization in different subjects. We explored persistent homology (PH) as a method for...
master thesis 2022
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van Wegen, Myla (author)
Parkinson’s Disease (PD) is one of the most common neuro-degenerative diseases worldwide, affecting patients’ ability to perform Activities of Daily Living (ADL), such as cooking and dressing, and consequently decreasing Quality of Life (QoL). Most ADL require dexterous skills which are often impaired in PD. Pharmacological therapy is often not...
master thesis 2022
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Sharifi, S. (author), Luft, F. (author), de Boer, L. (author), Buijink, A. W.G. (author), Mugge, W. (author), Schouten, A.C. (author), Heida, T. (author), Bour, L. J. (author), van Rootselaar, A. F. (author)
Tremor is thought to be an effect of oscillatory activity within the sensorimotor network. To date, the underlying pathological brain networks are not fully understood. Disentangling tremor activity from voluntary motor output and sensorimotor feedback systems is challenging. To better understand the intrinsic sensorimotor fingerprint...
journal article 2022
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Pool, D.M. (author), de Vries, Rick J. (author), Pel, Johan J.M. (author)
This paper investigates the potential of using a manual pursuit tracking task for quantifying loss of motor skills due to Parkinson's disease (PD), by applying human controller (HC) modeling techniques. With this approach, it is possible to obtain detailed quantitative data on motor performance in terms of control gain, response delay,...
journal article 2022
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Lugtenborg, Lieke A. (author), Pel, Johan J.M. (author), Pool, D.M. (author)
Parkinson's disease (PD) is a progressive nervous system disorder that affects movement. PD has a severely negative impact on the quality of life of patients and their caregivers. The timing of treatment depends, amongst others, on the quantification of patients' motor performance. To date, the resolution used in scaling motor performance is...
journal article 2022
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Vlaanderen, Floris P. (author), de Man, Yvonne (author), Tanke, Marit A.C. (author), Munneke, Marten (author), Atsma, Femke (author), Meinders, Marjan J. (author), Jeurissen, Patrick P.T. (author), Bloem, Bastiaan R. (author), Krijthe, J.H. (author), Groenewoud, Stef (author)
Background: Optimal care for Parkinson’s disease (PD) requires coordination and collaboration between providers within a complex care network. Individual patients have personalised networks of their own providers, creating a unique informal network of providers who treat (‘share’) the same patient. These ‘patient-sharing networks’ differ in...
journal article 2022
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Ferraro, F. (author), Fevga, Christina (author), Bonifati, Vincenzo (author), Mandemakers, Wim (author), Mahfouz, A.M.E.T.A. (author), Reinders, M.J.T. (author)
Several studies have analyzed gene expression profiles in the substantia nigra to better understand the pathological mechanisms causing Parkinson’s disease (PD). However, the concordance between the identified gene signatures in these individual studies was generally low. This might have been caused by a change in cell type composition as loss...
journal article 2022
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Assis de Souza, Alvaro (author)
Parkinson’s Disease (PD), Essential tremor (ET), and dystonia are movement disorders often misdiagnosed as one another and commonly present tremor as one of their motor symptoms. Rates of misdiagnosis between 30 and 50% of ET patients have been reported, where dystonia and PD are the most common missed diagnoses. Additionally, up to 50% of...
master thesis 2021
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Lugtenborg, Lieke (author)
Parkinson's disease can severely affect motor performance and impede in executing daily activities. Treatment can greatly improve patients' quality-of-life, however, disease detection and monitoring is still performed subjectively. Quantification of patients' motor performance and its decline due to increasing symptom severity using tracking...
master thesis 2020
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Yin, Z. (author)
Parkinson's disease (PD) diagnosis is based on clinical criteria, i.e. bradykinesia, rest tremor, rigidity, etc. Assessment of the severity of PD symptoms, however, is subject to inter-rater variability. In this paper, we propose a deep learning based automatic PD diagnosis method using videos recorded during the assessment with the Movement...
master thesis 2020
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Dekker, Melina (author)
Freezing of Gait (FoG) is a debilitating walking problem affecting over 50\% of Parkinson's Disease (PD) patients. Rhythmic cues during FoG can help patients to resume walking. FoG can be detected from lower limb acceleration data, but current detection algorithms lack context, resulting in false positive detection and initiation of cues when...
master thesis 2020
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Luft, Frauke (author), Sharifi, Sarvi (author), Mugge, W. (author), Schouten, A.C. (author), Bour, Lo J. (author), Van Rootselaar, Anne Fleur (author), Veltink, Peter H. (author), Heida, Tijtske (author)
Background: Parkinson's disease (PD) and essential tremor (ET) are neurodegenerative diseases characterized by movement deficits. Especially in PD, maintaining cyclic movement can be significantly disturbed due to pathological changes in the basal ganglia and the cerebellum. Providing external cues improves timing of these movements in PD and...
journal article 2020
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Rahmati, Zahra (author), Behzadipour, Saeed (author), Schouten, A.C. (author), Taghizadeh, Ghorban (author), Firoozbakhsh, Keikhosrow (author)
BACKGROUND: Balance training improves postural control in Parkinson's disease (PD). However, a systematic approach for the development of individualized, optimal training programs is still lacking, as the learning dynamics of the postural control in PD, over a training program, are poorly understood. OBJECTIVES: We investigated the learning...
journal article 2020
Searched for: subject%3A%22Parkinson%2527s%255C+disease%22
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