Characterizing the effects of delineation uncertainties in head and neck cancer radiotherapy

The goal of radiotherapy is to maximize the dose to the target while minimizing the dose to normal tissue. Treatment plans are optimized for this goal and dose delivery is improved in accuracy and precision. The optimization is based on the delineations of the volumes of interest on the medical images of the patient. The problem is that these...

Delineation uncertainties in radiotherapy: Modeling the effect of delineation uncertainties in radiotherapy with Polynomial Chaos Expansion

The delineation of the regions of interest (ROIs) plays an important role in the radiotherapy workflow. The ROIs include the gross tumor volume (GTV), the clinical target volume (CTV), the planning target volume (PTV) and organs at risk (OARs). There are however uncertainties related to the delineation of the ROIs due to inter­observer...