An Approach for Optimizing Prompt Gamma Photon-Based Range Estimation in Proton Therapy Using Cramér-Rao Theory

Various methods for in vivo range estimation during proton therapy based on the measurement of prompt gamma (PG) photons have been proposed. However, optimizing the method of detection by trial-and-error is a tedious endeavor. Here, we investigate the feasibility of using the Cramér-Rao lower bound (CRLB) to more quickly arrive at an optimum...