Searched for: subject%3A%22RNA%255C%2Bsequencing%22
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Biharie, Kirti (author)
Knowing the relation between cell types is crucial for translating experimental results from mice to humans. Establishing cell type matches, however, is hindered by the biological differences between the species. A substantial amount of evolutionary information between genes that could be used to align the species, is discarded by most of the...
master thesis 2022
document
Drummer, Francesca (author)
Single-cell sequencing allows measuring individual cells' molecular features and their responses to perturbations. Understanding which cells respond to a particular perturbation and how these responses vary across populations can be used to, for example, improve vaccine immunogenicity. However, an exhaustive exploration of single-cell...
master thesis 2022
document
Kalia, Yash (author)
Monitoring of SARS-CoV-2 variants is crucial to efforts in combating the COVID-19 pandemic. Lineage level abundance estimates for SARS-CoV-2 can be obtained from viral material present in domestic wastewater. The abundance predictions can be made at different levels of granularity-individual lineage level(high granularity) or variant level(low...
bachelor thesis 2022
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Viho, Eva M.G. (author), Buurstede, Jacobus C. (author), Berkhout, Jari B. (author), Mahfouz, A.M.E.T.A. (author), Meijer, Onno C. (author)
Glucocorticoid stress hormones are powerful modulators of brain function and can affect mood and cognitive processes. The hippocampus is a prominent glucocorticoid target and expresses both the glucocorticoid receptor (GR: Nr3c1) and the mineralocorticoid receptor (MR: Nr3c2). These nuclear steroid receptors act as ligand-dependent...
journal article 2021
document
Coutinho de Almeida, Rodrigo (author), Mahfouz, A.M.E.T.A. (author), Mei, Hailiang (author), Houtman, Evelyn (author), den Hollander, Wouter (author), Soul, Jamie (author), Suchiman, Eka (author), Nelissen, R.G.H.H. (author), Reinders, M.J.T. (author)
OBJECTIVE: To identify OA subtypes based on cartilage transcriptomic data in cartilage tissue and characterize their underlying pathophysiological processes and/or clinically relevant characteristics. METHODS: This study includes nā€‰=ā€‰66 primary OA patients (41 knees and 25 hips), who underwent a joint replacement surgery, from which...
journal article 2021
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Yu, W. (author), Mahfouz, A.M.E.T.A. (author), Reinders, M.J.T. (author)
The power of single-cell RNA sequencing (scRNA-seq) in detecting cell heterogeneity or developmental process is becoming more and more evident every day. The granularity of this knowledge is further propelled when combining two batches of scRNA-seq into a single large dataset. This strategy is however hampered by technical differences between...
journal article 2021
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Raz, Yotam (author), van den Akker, E.B. (author), Roest, Tijmen (author), Riaz, Muhammad (author), van de Rest, Ondine (author), Suchiman, H. Eka D. (author), Lakenberg, Nico (author), Stassen, Stefanie A. (author), Reinders, M.J.T. (author)
Skeletal muscles control posture, mobility and strength, and influence whole-body metabolism. Muscles are built of different types of myofibers, each having specific metabolic, molecular, and contractile properties. Fiber classification is, therefore, regarded the key for understanding muscle biology, (patho-) physiology. The expression of...
journal article 2020
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Verhagen, Mathijs (author)
Cancer metastasis, the spread of cancer to distant organs, is the major cause of cancerrelated mortality. Hence, understanding the mechanisms underlying cancer metastasis is crucial to improve clinical interventions. Despite intensive efforts, the driving mechanisms remain ill-understood due to the difficulties posed by studying the different...
master thesis 2019
document
Ruffroberts, A.L. (author), Kuenen, J.G. (author), Ward, D.M. (author)
journal article 1994
Searched for: subject%3A%22RNA%255C%2Bsequencing%22
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