Searched for: subject%3A%22Scale%255C+up%22
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Volger, R. (author), Puiman, L. (author), Haringa, C. (author)
The growing global population and heightened concern for climate change leads to increased interest in utilizing microbial fermentations to replace polluting production processes for e.g., plastics, fuels, and animal proteins. Computational fluid dynamics (CFD) is a valuable tool for accelerating the scale-up and optimization of large-scale...
review 2024
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Hosseini, A. (author)
HIsarna is a new and breakthrough smelting reduction technology for producing liquid hot metal for steelmaking directly from iron ores. Compared to the conventional blast furnace route, HIsarna achieves a 20% reduction in CO2 emissions by eliminating coking and the need for iron ore agglomeration processes such as sintering and pelletizing and...
doctoral thesis 2023
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ten Siethoff, Saskia (author)
Health systems globally, currently face many multi-faceted and dynamic challenges. There is a growing demand for quality healthcare, shifting expectations towards more responsibility for patients in their own health journey, an evolving role of technologies within society, and external pressures to decrease costs and improve sustainability in a...
master thesis 2023
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van de Ven, Pino (author)
This thesis report explores the integration of haptic technology in enterprise processes through the case of SenseGlove, a scale-up company based in YesDelft that produces Virtual Reality Gloves. The study aims to identify the potential barriers and requirements for the enterprise’s clients to adopt haptic technology and integrate it into their...
master thesis 2023
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Brouwer, Gijs (author)
Industrial biotechnology is labelled by the European Commission as one of the six key enabling technologies to fight climate change. Industrial biotechnology is a sector where biocatalysts (cells or enzymes) are used to convert renewable feedstocks (e.g. sugars) or even waste into valuable compounds such as renewable chemicals or food ...
master thesis 2023
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Nieto, Susana (author), Bernal, Juana M. (author), Villa Aroca, R. (author), Garcia-Verdugo, Eduardo (author), Donaire, Antonio (author), Lozano, Pedro (author)
A sustainable scaling-up process for the biocatalytic production of new bioactive provitamin-B<sub>5</sub> monoacyl esters has been demonstrated. A solvent-free reaction protocol, based on the formation of eutectic mixtures between neat substrates, renders highly efficient direct esterification of free fatty acids (i.e., from C<sub>6</sub> to...
journal article 2023
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Blake, J.W. (author), Konderla, V. (author), Baumgartner, L.M. (author), Vermaas, D.A. (author), Padding, J.T. (author), Haverkort, J.W. (author)
The use of gas diffusion electrodes that supply gaseous CO<sub>2</sub> directly to the catalyst layer has greatly improved the performance of electrochemical CO<sub>2</sub> conversion. However, reports of high current densities and Faradaic efficiencies primarily come from small lab scale electrolysers. Such electrolysers typically have a...
journal article 2023
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Minden, Steven (author), Aniolek, Maria (author), Noorman, H.J. (author), Takors, Ralf (author)
Commercial-scale bioreactors create an unnatural environment for microbes from an evolutionary point of view. Mixing insufficiencies expose individual cells to fluctuating nutrient concentrations on a second-to-minute scale while transcriptional and translational capacities limit the microbial adaptation time from minutes to hours. This...
journal article 2023
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Wu, K. (author), Wagner, E.C. (author), Ochkin-Koenig, Olga (author), Franck, Miika (author), Weis, Dominik (author), Meesters, G.M.H. (author), van Ommen, J.R. (author)
Mechanical vibration has been broadly used to assist fluidization of cohesive powders, because of its capability to disrupt gas channels and agglomerates. However, the improvement reported in literature is mostly deduced from bulk response and ex-situ measurements, whereas the induced fluidization behavior and underlying physics remain...
journal article 2023
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Puiman, L. (author), Almeida Benalcazar, E.F. (author), Picioreanu, C. (author), Noorman, H.J. (author), Haringa, C. (author)
In large-scale syngas fermentation, strong gradients in dissolved gas (CO, H<sub>2</sub>) concentrations are very likely to occur due to locally varying mass transfer and convection rates. Using Euler-Lagrangian CFD simulations, we analyzed these gradients in an industrial-scale external-loop gas-lift reactor (EL-GLR) for a wide range of...
journal article 2023
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Gallego Murillo, Joan Sebastián (author), Iacono, Giulia (author), van der Wielen, L.A.M. (author), van den Akker, Emile (author), von Lindern, Marieke (author), Wahl, S.A. (author)
Transfusion of donor-derived red blood cells (RBCs) is the most common form of cell therapy. Production of transfusion-ready cultured RBCs (cRBCs) is a promising replacement for the current, fully donor-dependent therapy. A single transfusion unit, however, contains 2 × 10<sup>12</sup> RBC, which requires large scale production. Here, we...
journal article 2022
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Baumgartner, L.M. (author), Koopman, C.I. (author), Forner-Cuenca, Antoni (author), Vermaas, D.A. (author)
Electrochemical CO2 reduction is a promising process to store intermittent renewable energy in the form of chemical bonds and to meet the demand for hydrocarbon chemicals without relying on fossil fuels. Researchers in the field have used gas diffusion electrodes (GDEs) to supply CO2 to the catalyst layer from the gas phase. This approach...
journal article 2022
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van Winden, Wouter A. (author), Mans, R. (author), Breestraat, Stefaan (author), Verlinden, Rob A.J. (author), Mielgo Gomez, A. (author), de Hulster, A.F. (author), de Bruijn, J.A. (author), Noorman, H.J. (author)
A novel fermentation process was developed in which renewable electricity is indirectly used as an energy source in fermentation, synergistically decreasing both the consumption of sugar as a first generation carbon source and emission of the greenhouse gas CO<sub>2</sub>. As an illustration, a glucose-based process is co-fed with formic acid...
journal article 2022
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Minden, Steven (author), Aniolek, Maria (author), Sarkizi Shams Hajian, Christopher (author), Teleki, Attila (author), Zerrer, Tobias (author), Delvigne, Frank (author), van Gulik, W.M. (author), Deshmukh, Amit (author), Noorman, H.J. (author), Takors, Ralf (author)
Carbon limitation is a common feeding strategy in bioprocesses to enable an efficient microbiological conversion of a substrate to a product. However, industrial settings inherently promote mixing insufficiencies, creating zones of famine conditions. Cells frequently traveling through such regions repeatedly experience substrate shortages and...
journal article 2022
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Baumgartner, L.M. (author), Koopman, C.I. (author), Forner-Cuenca, Antoni (author), Vermaas, D.A. (author)
Electrochemical CO2 reduction has the potential to use excess renewable electricity to produce hydrocarbon chemicals and fuels. Gas diffusion electrodes (GDEs) allow overcoming the limitations of CO2 mass transfer but are sensitive to flooding from (hydrostatic) pressure differences, which inhibits upscaling. We investigate the effect of the...
journal article 2022
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Angulo Lopez, Marice (author)
A lack of understanding of ecosystem-related projects and scarcity of natural capital reimbursement mechanisms leads to passive involvement and hesitation from the private sector when investing in nature. This study conducts a systematic literature review, furnishes a database of the relevant barriers and drivers for the private investment in...
master thesis 2021
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Kuğuoğlu, B.K. (author), van der Voort, H.G. (author), Janssen, M.F.W.H.A. (author)
Despite the promise of AI and IoT, the efforts of many organizations at scaling smart city initiatives fall short. Organizations often start by exploring the potential with a proof-of-concept and a pilot project, with the process later grinding to a halt for various reasons. Pilot purgatory, in which organizations invest in small-scale...
journal article 2021
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Duong, Hong T. (author), Wu, Y. (author), Sutor, Alexander (author), Burek, Bastien O. (author), Hollmann, F. (author), Bloh, Jonathan Z. (author)
Light-driven biocatalytic processes are notoriously hampered by poor penetration of light into the turbid reaction media. In this study, wirelessly powered light-emitting diodes are found to represent an efficient and scalable approach for process intensification of the photobiosynthetic production of diesel alkanes from renewable fatty acids...
journal article 2021
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Jose, Nicholas A. (author), Kovalev, Mikhail (author), Bradford, Eric (author), Schweidtmann, A.M. (author), Chun Zeng, Hua (author), Lapkin, Alexei A. (author)
Novel materials are the backbone of major technological advances. However, the development and wide-scale introduction of new materials, such as nanomaterials, is limited by three main factors—the expense of experiments, inefficiency of synthesis methods and complexity of scale-up. Reaching the kilogram scale is a hurdle that takes years of...
journal article 2021
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Eghbal Sarabi, F. (author), Liu, J. (author), Stankiewicz, A.I. (author), Nigar, H. (author)
Microwave heating presents a potentially green alternative for energy supply to chemical and catalytic reactors as it can be based on the electricity from renewable sources. The Reverse Traveling Microwave Reactor (RTMR) is a novel heterogeneous catalytic reactor concept, based on the coaxial waveguide structure. The reactor has two microwave...
journal article 2021
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