Searched for: subject%3A%22Sialic%255C+acids%22
(1 - 7 of 7)
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Peters, J.A. (author), Djanashvili, K. (author)
In this review, the chemical mechanisms behind the interactions between boronic acids and N-acetylneuraminic acids, which have been widely utilized in biomedicine in recent decades, will be examined. It will also be highlighted that the affinity of boronic acids for N-acetylneuraminic acids is dependent on pH and is complementary to their...
review 2023
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Kleikamp, H.B.C. (author)
The large unexplored space of microbial biodiversity forms a well of untapped potential of enzymes and bioactive compounds. Genomic methods have made significant improvements over the past decades in their analysis of microbial communities. However, several aspects of nature can’t be described by a genome alone, such as expressed functions in...
doctoral thesis 2022
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Geraldes, Carlos F.G.C. (author), Peters, J.A. (author)
Molecular recognition involving glycoprotein-mediated interactions is ubiquitous in both normal and pathological natural processes. Therefore, visualization of these interactions and the extent of expression of the sugars is a challenge in medical diagnosis, monitoring of therapy, and drug design. Here, we review the literature on the...
review 2022
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Martinelli, J. (author), Tei, Lorenzo (author), Geninatti Crich, Simonetta (author), Alberti, Diego (author), Djanashvili, K. (author)
It is known that phenylboronic acid (PBA) can target tumor tissues by binding to sialic acid, a substrate overexpressed by cancer cells. This capability has previously been explored in the design of targeting diagnostic probes such as Gd- and 68Ga-DOTA-EN-PBA, two contrast agents for magnetic resonance imaging (MRI) and positron emission...
journal article 2021
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Tomas Martinez, S. (author), Kleikamp, H.B.C. (author), Neu, Thomas R. (author), Pabst, Martin (author), Weissbrodt, D.G. (author), van Loosdrecht, Mark C.M. (author), Lin, Y. (author)
Nonulosonic acids (NulOs) are a family of acidic carbohydrates with a nine-carbon backbone, which include different related structures, such as sialic acids. They have mainly been studied for their relevance in animal cells and pathogenic bacteria. Recently, sialic acids have been discovered as an important compound in the extracellular...
journal article 2021
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Pinel, I.S.M. (author), Kleikamp, H.B.C. (author), Pabst, Martin (author), Vrouwenvelder, J.S. (author), van Loosdrecht, Mark C.M. (author), Lin, Y. (author)
Sialic acids in the structural matrix of biofilms developing in engineered water systems constitute a potential target in the battle against biofouling. This report focuses specifically on the presence of sialic acids as part of the extracellular polymeric substances (EPS) of biofilms forming in cooling towers and the potential effect of...
journal article 2020
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de Graaff, D.R. (author), Felz, S. (author), Neu, Thomas R. (author), Pronk, M. (author), van Loosdrecht, Mark C.M. (author), Lin, Y. (author)
Sialic acids have been discovered in the extracellular polymeric substances (EPS) of seawater-adapted aerobic granular sludge (AGS). Sialic acids are a group of monosaccharides with a nine-carbon backbone, commonly found in mammalian cells and pathogenic bacteria, and frequently described to protect EPS molecules and cells from attack by...
journal article 2019
Searched for: subject%3A%22Sialic%255C+acids%22
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