Development of a Patient-Specific Carotid Artery Fluid-Structure-Interaction Model

Background: <br/>Ischemic stroke is a major cause of death worldwide. Atherosclerosis in the carotid<br/>arteries is an established predictor of these events. FSI shows its advantage in simulating the hemodynamic environments due to involving the multiphysics coupling of fluid dynamics and structural mechanics regulations. Therefore, the aim of...

From CTA to 3D modelling: A computational framework for morphometrical assessment and biomechanical analysis of atherosclerotic carotid arteries

Background: Ischemic stroke is a major cause of death worldwide. Atherosclerosis in the carotid arteries is an established predictor of these events. Ideally, patient-specific prevention plans can be developed that target advanced plaque development prior to events. Morphometry of advanced calcified plaque phenotypes can be assessed through...

An effective notch stress concept based total fatigue life estimate of maritime structures

Fatigue is typically a governing limit state for maritime structures, and weld joints are the most critical locations. Various fatigue damage criteria have been developed involving either an intact or cracked geometry parameter, incorporating local or global information. In this thesis, the effective notch stress based total life fatigue damage...

Application of OCT and IVUS to investigate the combined effect of plaque structural stress and wall shear stress on plaque progression in human coronary arteries

Introduction: Atherosclerosis, the major source of cardiovascular diseases, is one of the leading causes of death. During atherosclerosis the arterial wall is affected by a complex process of lipid driven inflammation that leads to thickening of the arterial wall resulting in a so called plaque. Because of plaque growth, the lumen of the artery...

Multiaxial Fatigue due to Wave Induced Accelerations in a Flex-lay Tower Structure

Marine and offshore structures are continuously exposed to different loading types. Cyclic loads results in cyclic stresses in structural components, which may result in degradation of the structural integrity. This process is called fatigue. Fatigue damage of structural components usually occurs without any —global— visible sign. Ultimately,...