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Malubhoy, Zahabiya (author), Bahia, Frederico Mendonça (author), de Valk, Sophie Claire (author), de Hulster, A.F. (author), Rendulić, Toni (author), Ortiz, Juan Paulo Ragas (author), Xiberras, Joeline (author), Klein, Mathias (author), Mans, R. (author), Nevoigt, Elke (author)Background: The microbial production of succinic acid (SA) from renewable carbon sources via the reverse TCA (rTCA) pathway is a process potentially accompanied by net-fixation of carbon dioxide (CO<sub>2</sub>). Among reduced carbon sources, glycerol is particularly attractive since it allows a nearly twofold higher CO<sub>2</sub>-fixation...journal article 2022
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Liu, Y. (author), Esen, Osman (author), Pronk, J.T. (author), van Gulik, W.M. (author)This study explores the relation between biomass-specific succinic acid (SA) production rate and specific growth rate of an engineered industrial strain of Saccharomyces cerevisiae, with the aim to investigate the extent to which growth and product formation can be uncoupled. Ammonium-limited aerobic chemostat and retentostat cultures were...journal article 2021
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Liu, Y. (author)The progress of modern biotechnology has enabled the development of fermentation processes for the production of fuels and chemicals from renewable feedstocks. The current fermentation processes for bio-based production commonly start with a growth phase of the microorganisms followed by a production phase. This implies that biomass formation...doctoral thesis 2020
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Xiberras, Joeline (author), Klein, Mathias (author), de Hulster, A.F. (author), Mans, R. (author), Nevoigt, Elke (author)Previously, our lab replaced the endogenous FAD-dependent pathway for glycerol catabolism in S. cerevisiae by the synthetic NAD-dependent dihydroxyacetone (DHA) pathway. The respective modifications allow the full exploitation of glycerol’s higher reducing power (compared to sugars) for the production of the platform chemical succinic acid ...journal article 2020
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Wahl, S.A. (author), Bernal Martinez, C. (author), Zhao, Zheng (author), van Gulik, W.M. (author), Jansen, Mickel L.A. (author)Background: The metabolic engineering of Saccharomyces cerevisiae for the production of succinic acid has progressed dramatically, and a series of high-producing hosts are available. At low cultivation pH and high titers, the product transport can become bidirectional, i.e. the acid is reentering the cell and is again exported or even...journal article 2017
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Fakkert, S.C.M. (author)Within the context of growing concerns about oil supply security and greenhouse gas emissions, both the aviation and petrochemical sector are exploring alternative feedstocks for the production of jet fuel and chemicals, respectively. In that light, research into bio-based jet fuels (biojet fuel) and bio-based chemicals has been accelerating in...master thesis 2016
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- Jamalzadeh, E. (author) doctoral thesis 2013