A comprehensive characterization of the time resolution of the Philips Digital Photon Counter

Photodetectors with excellent time resolution are becoming increasingly important in many applications in medicine, high energy- and nuclear physics applications, biology, and material science. Silicon photomultipliers (SiPM) are a novel class of solid-state photodetectors with good timing properties. While the time resolution of analog SiPMs...

Multichannel Digital Silicon Photomultipliers for Time-of-Flight PET

This thesis discusses the potential of CMOS based SiPMs, especially for TOF PET applications, in a systematic and comprehensive fashion. CMOS based SPADs are still need to be designed carefully to improve fill factor, TDCs be improved from the point of the area and power consumption, and the necessity of high voltage for SPADs be handled...

A 4 X 4 X 416 digital SiPM array with 192 TDCs for multiple high-resolution timestamp acquisition

We present a 4 X 4 array of digital silicon photomultipliers (D-SiPMs) capable of timestamping up to 48 photons per D-SiPM and we show the advantage of generating multiple timestamps in the context of positron emission tomography (PET). The D-SiPMs have a pitch of 800 ?m and comprise 416 pixels each; the timing resolution achieved by the SiPMs...

Iron-Storage Mechanism of Ferritin

Storage of Fe(III) is a common mechanism by which the cellular machinery controls the availability of Fe(II) and Fe(III) for biosynthesis of iron-containing cofactors of enzymes which are involved in several essential biological processes, including oxidative phosphorylation. The conserved 24-meric iron-storage protein ferritin has been...

Silicon Photomultipliers and Monolithic Scintillators for Time-of-Flight PET

Positron emission tomography (PET) is a nuclear medical imaging modality. Its aim is to visualize the 3-dimensional distribution of a radiopharmaceutical (also called the tracer) within a patient (clinical PET) or test-animal (in case of preclinical investigations). The information that can be obtained from the reconstructed distribution depends...