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Bouter, P.A. (author)In recent years, the use of Artificial Intelligence (AI) has become prevalent in a large number of societally relevant, real-world problems, e.g., in the domains of engineering and health care. The field of Evolutionary Computation (EC) can be considered to be a sub-field of AI, concerning optimization using Evolutionary Algorithms (EAs), which...doctoral thesis 2023
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VilasBoas-Ribeiro, Iva (author), Franckena, Martine (author), van Rhoon, G.C. (author), Hernandez-Tamames, J.A. (author), Paulides, Margarethus M. (author)Purpose: We studied the differences between planning and treatment position, their impact on the accuracy of hyperthermia treatment planning (HTP) predictions, and the relevance of including true treatment anatomy and position in HTP based on magnetic resonance (MR) images. Materials and methods: All volunteers were scanned with an MR...journal article 2023
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Maasland, Anouk (author)The aim of this thesis is to study the dosimetric feasibility of FLASH proton therapy for early-stage breast cancer patients. The biological effect of FLASH is seen under ultra-high dose-rates conditions and is beneficial in the damage to healthy tissue. The FLASH effect could enable the clinical feasibility of definitive radiotherapy for low...master thesis 2022
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Negenman, Eva (author)Purpose: Proton therapy has been proposed as an alternative to conventional photon therapy for the treatment of locally advanced cervical cancer (LACC) since these patients experience toxicities. Proton therapy may allow for significant sparing of the organs at risk, reducing the incidence of treatment-related morbidities. The aim of this study...master thesis 2022
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van der Hoeven, Thijs (author)Treatment planning for radiation therapy is a complex process, as there are many machine parameters to determine for a treatment. To decrease the required labour and improve the plan quality, auto-planning systems have been developed, which can automatically generate high-quality treatment plans. These plans still have to be checked to ensure...master thesis 2022
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Androulakis, Ioannis (author), Mestrom, Rob M.C. (author), Christianen, Miranda E.M.C. (author), Kolkman‐deurloo, Inger Karine K. (author), van Rhoon, G.C. (author)The combination of interstitial hyperthermia treatment (IHT) with high dose rate brachytherapy (HDR‐BT) can improve clinical outcomes since it highly enhances the efficiency of cell kill, especially when applied simultaneously. Therefore, we have developed the ThermoBrachy applicators. To effectively apply optimal targeted IHT, treatment...journal article 2022
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Androulakis, Ioannis (author), Mestrom, Rob M.C. (author), Christianen, Miranda E.M.C. (author), Kolkman-Deurloo, Inger Karine K. (author), van Rhoon, G.C. (author)In high-dose-rate brachytherapy (HDR-BT) for prostate cancer treatment, interstitial hyperthermia (IHT) is applied to sensitize the tumor to the radiation (RT) dose, aiming at a more efficient treatment. Simultaneous application of HDR-BT and IHT is anticipated to provide maximum radiosensitization of the tumor. With this rationale, the...journal article 2022
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Niekolaas, Sofieke (author)Radiotherapy is one of the main treatment modalities available to treat cancer. Radiotherapy treatment plans are created based on CT scans of the patient. In such scans the macroscopic tumor is visible, but microscopic disease present in the surrounding tissue cannot be observed. To achieve an optimal clinical outcome, both the macroscopic and...master thesis 2021
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Mühlsteff, Joris (author)In intensity modulated proton therapy (IMPT), patients are irradiated with small spots, that deliver a local dose to the tumor. The number of possible spots to choose from is virtually infinite, but practically limited, which requires a spot selection. This spot selection should result in an optimal treatment plan, i.e., to deliver a sufficient...master thesis 2021
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Corbeau, Anouk (author)Each year, more than 800 women in the Netherlands are diagnosed with cervical cancer, of which approximately half have locally advanced disease. The standard treatment for locally advanced cervical cancer (LACC) is external beam radiotherapy (EBRT) with concurrent chemotherapy followed by brachytherapy. Many patients experience some degree of...master thesis 2021
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Meerbothe, Thierry (author)Radiotherapy treatment planning is a complex and time consuming process prone to differences as result of choices of individual planners. Autoplanning systems have been introduced to both reduce the time consumption and to counteract the influence of individual planning choices. Although autoplanning generally increases performance of the...master thesis 2021
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Rojo-Santiago, Jesús (author), Habraken, S.J.M. (author), Lathouwers, D. (author), Méndez Romero, Alejandra (author), Perko, Z. (author), Hoogeman, M.S. (author)Background and purpose: Scenario-based robust optimization and evaluation are commonly used in proton therapy (PT) with pencil beam scanning (PBS) to ensure adequate dose to the clinical target volume (CTV). However, a statistically accurate assessment of the clinical application of this approach is lacking. In this study, we assess target...journal article 2021
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Steinebach, Koen (author)In proton therapy, robust treatment planning is currently used to account for uncertainties in patient alignment and proton beam range. A way to overcome the limitations of robust treatment planning is to use probabilistic treatment planning, which can be computationally expensive due to the calculations of statistical measures of stochastic...master thesis 2020
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Groen, J.A. (author)Radiotherapy (RT) is an important modality in treatment against cancer. Developments in this modality are necessary for improvement of patient complications and survival. Aside from fractionation and precise irradiation, FLASH radiotherapy could be a third way to significantly increase the therapeutic window of radiotherapy.The FLASH effect is a...master thesis 2020
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Oud, Michelle (author), Kolkman-Deurloo, Inger Karine (author), Mens, J.W. (author), Lathouwers, D. (author), Perko, Z. (author), Heijmen, Ben (author), Breedveld, Sebastiaan (author)Purpose: To develop and evaluate a fast, automated multi-criterial treatment planning approach for adaptive high-dose-rate (HDR) intracavitary + interstitial brachytherapy (BT) for locally advanced cervical cancer. Methods and materials: Twenty-two previously delivered single fraction MRI-based HDR treatment plans (SF<sub>clin</sub>) were...journal article 2020
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Vilasboas-Ribeiro, Iva (author), van Rhoon, G.C. (author), Drizdal, Tomas (author), Franckena, Martine (author), Paulides, Margarethus M. (author)In hyperthermia, the general opinion is that pre-treatment optimization of treatment settings requires a patient-specific model. For deep pelvic hyperthermia treatment planning (HTP), tissue models comprising four tissue categories are currently discriminated. For head and neck HTP, we found that more tissues are required for increasing...journal article 2020
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Oud, Michelle (author)Purpose - To develop and evaluate a fast and automated multi-criterial treatment planning strategy for High-Dose-Rate (HDR) brachytherapy (BT) for patients with locally advanced cervical cancer. This automated strategy avoids suboptimal and slow manual treatment planning and results in reproducible and conformal treatment plans with a clinically...master thesis 2019
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Vos, Kelly (author)Cancer is a disease that one of every three people will get in The Netherlands. One of the treatment methods for this disease is radiotherapy. Approximately half of all cancer patients will get radiotherapy at some point of their treatment. During radiotherapy cancer cells are destroyed with ionizing radiation, but healthy cells get destroyed...bachelor thesis 2019
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Salverda, Jelle (author)Radiotherapy is an important treatment type for patients with cancer. An advantage of state of the art proton therapy with respect to traditional photon therapy is the spatial energy deposition of protons, which is characterized by the Bragg peak. Due to this particular course of energy deposition, the tumor can be irradiated more precisely and...master thesis 2019
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Schipaanboord, B.W.K. (author), Breedveld, S. (author), Rossi, L. (author), Keijzer, M. (author), Heijmen, Ben (author)Segmentation can degrade a high-quality dose distribution obtained by fluence map optimisation (FMO). A novel algorithm is proposed for generation of MLC segments to deliver an FMO plan with step-and-shoot IMRT while minimising quality loss. All beams are considered simultaneously while generating MLC segments for reproducing the 3D FMO dose...journal article 2019
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