Searched for: subject%3A%22Tuberculosis%22
(1 - 12 of 12)
document
van Lieshout, Ana (author)
Prisons serve as amplifiers of Tuberculosis (TB) transmission due to overpopulation, lack of hygiene, and bad ventilation [Mabud et al., 2019] [Baussano et al., 2010]. The risk of TB is elevated during and after incarceration, only returning to the general population’s risk seven years after liberation. This is an indication that formerly...
bachelor thesis 2023
document
Anyansi, C.A. (author)
This thesis represents one small step in the battle with TB, where we apply WGS approaches to explore different topics of TB research. Here we offer the global community a method to diagnose complex TB infections consisting of multiple distinct strains. We show that this functionality is necessary and has been overlooked by the TB community in...
doctoral thesis 2021
document
Anyansi, C.A. (author), Keo, D. (author), Walker, Bruce J. (author), Straub, Timothy J. (author), Manson, Abigail L. (author), Earl, Ashlee M. (author), Abeel, T.E.P.M.F. (author)
Background: Mixed infections of Mycobacterium tuberculosis and antibiotic heteroresistance continue to complicate tuberculosis (TB) diagnosis and treatment. Detection of mixed infections has been limited to molecular genotyping techniques, which lack the sensitivity and resolution to accurately estimate the multiplicity of TB infections. In...
journal article 2020
document
Cohen, Keira A. (author), Manson, Abigail L. (author), Abeel, T.E.P.M.F. (author), Desjardins, Christopher A. (author), Chapman, Sinead B. (author), Hoffner, Sven (author), Birren, Bruce W. (author), Earl, Ashlee M. (author)
Background: While the international spread of multidrug-resistant (MDR) Mycobacterium tuberculosis strains is an acknowledged public health threat, a broad and more comprehensive examination of the global spread of MDR-tuberculosis (TB) using whole-genome sequencing has not yet been performed. Methods: In a global dataset of 5310 M....
journal article 2019
document
Marinus, tycho (author)
While the sequencing era has greatly increased the amount of protein sequences, in the eld of protein structure this increase has not occurred, mostly due to the high cost and workload of protein structure determination. This has resulted in a large gap between the amount of protein sequences and protein structures. In the case of TB drug...
master thesis 2018
document
Hards, Kiel (author), McMillan, D.G.G. (author), Schurig-Briccio, Lici A. (author), Gennis, Robert B. (author), Lill, Holger (author), Bald, Dirk (author), Cook, Gregory M. (author)
Bedaquiline (BDQ), an inhibitor of the mycobacterial F<sub>1</sub>F<sub>o</sub>-ATP synthase, has revolutionized the antitubercular drug discovery program by defining energy metabolism as a potent new target space. Several studies have recently suggested that BDQ ultimately causes mycobacterial cell death through a phenomenon known as...
journal article 2018
document
Vrieling, Frank (author), Ronacher, Katharina (author), Kleynhans, Léanie (author), van den Akker, E.B. (author), Walzl, Gerhard (author), Ottenhoff, Tom H.M. (author), Joosten, Simone A. (author)
Background: Type 2 diabetes mellitus (DM) is a major risk factor for development of tuberculosis (TB), however the underlying molecular foundations are unclear. Since lipids play a central role in the development of both DM and TB, lipid metabolism may be important for TB-DM pathophysiology. Methods: A <sup>1</sup> H NMR spectroscopy-based...
journal article 2018
document
Mouzos, L. (author)
In recent years, cheap sequencing has resulted in hundreds or thousands of individual genomes available for many species. Therefore, it is logical to rethink the concept of the reference genome; as consisting of a population of genomes rather than being a single one. The term pan-genome describes a population of genomes of the same species or a...
master thesis 2017
document
Mouzos, L. (author)
In recent years, cheap sequencing has resulted in hundreds or thousands of individual genomes available for many species. Therefore, it is logical to rethink the concept of the reference genome; as consisting of a population of genomes rather than being a single one. The term pan-genome describes a population of genomes of the same species or a...
master thesis 2017
document
Manson, Abigail L. (author), Cohen, Keira A (author), Abeel, T.E.P.M.F. (author), Desjardins, Christopher A. (author), Armstrong, Derek T. (author), Barry III, Clifton E. (author), Brand, Jeannette (author), Chapman, Sinéad B. (author), Cho, Sang-Nae (author), Gabrielian, Andrei (author), Salazar, A.N. (author)
Multidrug-resistant tuberculosis (MDR-TB), caused by drug-resistant strains of Mycobacterium tuberculosis, is an increasingly serious problem worldwide. Here we examined a data set of whole-genome sequences from 5,310 M. tuberculosis isolates from five continents. Despite the great diversity of these isolates with respect to geographical...
journal article 2017
document
Keo, D. (author)
Tuberculosis is a pulmonary disease caused by the pathogen Mycobacterium tuberculosis and is the second leading cause of death from an infectious disease. Individuals infected by multiple strains referred to as a mixed infection are associated with poor treatment outcomes when the infecting strains differ in their susceptibility against...
master thesis 2016
document
Houben, D. (author)
The aim of this thesis is to determine the properties of the compartment where mycobacteria end up after phagocytosis and which mycobacterial genes play a role in this process. In most cases, bacterial pathogens are taken up by the cell, processed in the endocytic pathway and eventually bacterial derived peptides are presented on MHC class II...
doctoral thesis 2011
Searched for: subject%3A%22Tuberculosis%22
(1 - 12 of 12)