Searched for: subject%3A%22Tumor%22
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Hoekstra, Mirjam E. (author), Slagter, Maarten (author), Urbanus, Jos (author), Toebes, Mireille (author), Slingerland, Nadine (author), de Rink, Iris (author), Kluin, Roelof J.C. (author), Nieuwland, Marja (author), Wessels, L.F.A. (author)
Cells in the tumor microenvironment (TME) influence each other through secretion and sensing of soluble mediators, such as cytokines and chemokines. While signaling of interferon γ (IFNγ) and tumor necrosis factor α (TNFα) is integral to anti-tumor immune responses, our understanding of the spatiotemporal behavior of these cytokines is...
journal article 2024
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Spengler, Daniel (author)
The study of tumor microenvironments (TMEs) and immune cell composition in cancer, a disease characterized by uncontrolled growth and spread of tumor cells, has become increasingly important for understanding tumor progression and patient outcomes. Tools such as the TME-Analyzer enable this kind of research, but their manual workflows highlight...
master thesis 2023
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Androulakis, Ioannis (author), Ferrero, Riccardo (author), van Oossanen, R. (author), Manzin, Alessandra (author), Denkova, A.G. (author), Djanashvili, K. (author), Nadar, R.A. (author), van Rhoon, G.C. (author)
While hyperthermia has been shown to induce a variety of cytotoxic and sensitizing effects on cancer tissues, the thermal dose–effect relationship is still not well quantified, and it is still unclear how it can be optimally combined with other treatment modalities. Additionally, it is speculated that different methods of applying...
journal article 2023
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Weeda, Ylva (author)
Gastrointestinal stromal tumours (GISTs) are rare mesenchymal neoplasms with a worldwide incidence of one or two per 100,000. The tumours affect the entire gastrointestinal tract, but most commonly the stomach and small intestine. Neoadjuvant tyrosine kinase inhibitors (TKI) are administered in a selection of GIST patients to attain size...
master thesis 2023
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van Tienderen, Gilles S. (author), van Beek, M.E.A. (author), Schurink, Ivo J. (author), Rosmark, Oskar (author), Roest, Henk P. (author), Demmers, J.A.A. (author), Muntz, I.A.A. (author), Conboy, J.P. (author), Koenderink, G.H. (author)
Cholangiocarcinoma (CCA) is a type of liver cancer with an aggressive phenotype and dismal outcome in patients. The metastasis of CCA cancer cells to distant organs, commonly lung and lymph nodes, drastically reduces overall survival. However, mechanistic insight how CCA invades these metastatic sites is still lacking. This is partly because...
journal article 2023
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Liu, H. (author), Nadar, R.A. (author), Fauzia, R.P. (author), Laan, A.C. (author), Wang, R. (author), van Cooten, Quenteijn (author), Carroll, E.C.M. (author), Eelkema, R. (author), Denkova, A.G. (author)
Combination of therapies is a common strategy in cancer treatment. Such combined therapies only have merit provided that there is superior therapeutic outcome with fewer side effects, compared to single therapies. Here, this work explores the possibility to combine chemotherapy with radionuclide therapy using polymeric micelles as a delivery...
journal article 2023
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Hoogstrate, Youri (author), Draaisma, Kaspar (author), Barin, N. (author), Taphoorn, Martin J.B. (author), Weyerbrock, Astrid (author), Sanson, Marc (author), Hoeben, Ann (author), Lukacova, Slávka (author), Lombardi, Giuseppe (author), Hanse, Monique (author), Fleischeuer, Ruth E.M. (author), Watts, Colin (author), Angelopoulos, Nicos (author), Gorlia, Thierry (author), Robe, Pierre A. (author), French, P.J. (author)
A better understanding of transcriptional evolution of IDH-wild-type glioblastoma may be crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq) (n = 322 test, n = 245 validation) on paired primary-recurrent glioblastoma resections of patients treated with the current standard of care. Transcriptional subtypes form an...
journal article 2023
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Thomsen, L.C.V. (author), Kleinmanns, Katrin (author), Anandan, Shamundeeswari (author), Gullaksen, Stein Erik (author), Abdelaal, T.R.M. (author), Iversen, Grete Alrek (author), Akslen, Lars Andreas (author), McCormack, Emmet (author), Bjørge, Line (author)
The prognosis of high-grade serous ovarian carcinoma (HGSOC) is poor, and treatment selection is challenging. A heterogeneous tumor microenvironment (TME) characterizes HGSOC and influences tumor growth, progression, and therapy response. Better characterization with multidimensional approaches for simultaneous identification and...
journal article 2023
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Rojo-Santiago, Jesús (author), Habraken, S.J.M. (author), Romero, Alejandra Méndez (author), Lathouwers, D. (author), Wang, Yibing (author), Perko, Z. (author), Hoogeman, M.S. (author)
Objective. The Dutch proton robustness evaluation protocol prescribes the dose of the clinical target volume (CTV) to the voxel-wise minimum (VWmin) dose of 28 scenarios. This results in a consistent but conservative near-minimum CTV dose (D98%,CTV). In this study, we analyzed (i) the correlation between VWmin/voxel-wise maximum (VWmax)...
journal article 2023
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Peters, J.A. (author), Djanashvili, K. (author)
In this review, the chemical mechanisms behind the interactions between boronic acids and N-acetylneuraminic acids, which have been widely utilized in biomedicine in recent decades, will be examined. It will also be highlighted that the affinity of boronic acids for N-acetylneuraminic acids is dependent on pH and is complementary to their...
review 2023
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Mai, Zhijian (author), Cao, Nengjie (author), Cheng, Erzhuo (author), Zeng, Zhiwen (author), Feng, Yancong (author), Wang, Yao (author), French, P.J. (author), Lee, Yi Kuen (author), Yang, Haihong (author)
To develop multifunctional small-molecule prodrugs is highly desirable for cancer treatment but remains challenging in intrinsic traceability. As an acid-cleavable linkage, a Schiff bases benefiting from its distinctive fluorescence quenching ability was selected to prepare a small-molecule prodrug with cancer-targeted and self-indicating. In...
journal article 2023
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Breda, Rebecca (author)
Breast cancer is the most prevalent form of cancer among women, leading to 2.3 million new diagnosis and almost 685,000 deaths in 2020. Currently, one of the preferred treatments is breast conserving surgery (BCS), but its success depends on the correct identification of tumor margins during surgery. A promising optical intraoperative margin...
master thesis 2022
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Starmans, Martijn P.A. (author), Timbergen, Milea J.M. (author), Vos, Melissa (author), Renckens, Michel (author), Grünhagen, Dirk J. (author), van Leenders, Geert J.L.H. (author), Niessen, W.J. (author), Visser, Jacob J. (author), Klein, Stefan (author)
Treatment planning of gastrointestinal stromal tumors (GISTs) includes distinguishing GISTs from other intra-abdominal tumors and GISTs’ molecular analysis. The aim of this study was to evaluate radiomics for distinguishing GISTs from other intra-abdominal tumors, and in GISTs, predict the c-KIT, PDGFRA, BRAF mutational status, and mitotic...
journal article 2022
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Dieckman, Tessa (author), Schreurs, Mette (author), Mahfouz, A.M.E.T.A. (author), Kooy-Winkelaar, Yvonne (author), Neefjes-Borst, Andra (author), Bouma, Gerd (author), Koning, Frits (author)
Background &amp; Aims: Refractory celiac disease type II (RCDII) is a rare indolent lymphoma in the small intestine characterized by a clonally expanded intraepithelial intracellular CD3<sup>+</sup>surfaceCD3<sup>-</sup>CD7<sup>+</sup>CD56<sup>-</sup> aberrant cell population. However, RCDII pathogenesis is ill-defined. Here, we aimed at...
journal article 2022
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Brouwer, Thomas P. (author), de Vries, Natasja L. (author), Abdelaal, T.R.M. (author), Li, Zheng (author), Ruano, Dina (author), Fariña, Arantza (author), Lelieveldt, B.P.F. (author), Morreau, Hans (author), Vahrmeijer, Alexander L. (author)
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy in need of effective (immuno)therapeutic treatment strategies. For the optimal application and development of cancer immunotherapies, a comprehensive understanding of local and systemic immune profiles in patients with PDAC is required. Here, our goal was to...
journal article 2022
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Su, Pin Rui (author), You, L. (author), Beerens, Cecile (author), Bezstarosti, Karel (author), Demmers, J.A.A. (author), Pabst, Martin (author), Kanaar, R. (author), Hsu, Cheng Chih (author), Chien, M.P. (author)
Single-cell proteomics has the potential to decipher tumor heterogeneity, and a method like single-cell proteomics by mass spectrometry (SCoPE-MS) allows profiling several tens of single cells for &gt;1,000 proteins per cell. This method, however, cannot link the proteome of individual cells with phenotypes of interest. Here, we developed a...
journal article 2022
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Mehta, P.P. (author), Rahman, Z. (author), ten Dijke, Peter (author), Boukany, P. (author)
An early step of metastasis requires a complex and coordinated migration of invasive tumor cells into the surrounding tumor microenvironment (TME), which contains extracellular matrix (ECM). It is being appreciated that 3D matrix-based microfluidic models have an advantage over conventional in vitro and animal models to study tumor...
review 2022
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Rosbergen, Mathijs (author)
Introduction: Gliomas are the most common primary malignant brain tumours with a very poor survival. Resistance to chemotherapy and radiotherapy often occurs in these tumours due to hypoxia, which can be caused by different oxygenation parameters. Multiple magnetic resonance imaging (MRI) techniques are able to assess these oxygenation...
master thesis 2021
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van der Molen, Dana (author)
Glioblastoma multiforme tumors (GBM) are the most frequent and aggressive brain tumor type and have a very low survival rate. In order to improve the patient’s outcome for a patient suffering from GBM the production of brain phantoms can be of great help. A brain phantom can be used for multiple purposes, such as neurological planning, training...
master thesis 2021
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Burghoorn, Niels (author)
During cancer development, the tumor cell population usually emerges from a single cell ancestor and can therefore be categorized as clonal. As a result of the genomic instability and selection within this clonal population, additional mutations take place and allow for the differentiation of cell lineages. This tumor heterogeneity can be...
bachelor thesis 2021
Searched for: subject%3A%22Tumor%22
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