Searched for: subject%3A%22Wound%255C+contraction%22
(1 - 9 of 9)
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Egberts, G. (author), Vermolen, F.J. (author), van Zuijlen, Paul (author)
We consider the stability analysis of a two-dimensional model for post-burn contraction. The model is based on morphoelasticity for permanent deformations and combined with a chemical-biological model that incorporates cellular densities, collagen density, and the concentration of chemoattractants. We formulate stability conditions depending...
journal article 2023
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Egberts, G. (author), Desmoulière, Alexis (author), Vermolen, F.J. (author), van Zuijlen, Paul (author)
We consider a two-dimensional biomorphoelastic model describing post-burn scar contraction. This model describes skin displacement and the development of the effective Eulerian strain in the tissue. Besides these mechanical components, signaling molecules, fibroblasts, myofibroblasts, and collagen also play a significant role in the model. We...
journal article 2022
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Egberts, G. (author), Vermolen, F.J. (author), van Zuijlen, Paul (author)
We consider a one-dimensional morphoelastic model describing post-burn scar contraction. Contraction can lead to a limited range of motion (contracture). Reported prevalence of burn scar contractures are 58.6% at 3–6 weeks and 20.9% at 12 months post-reconstructive surgery after burns. This model describes the displacement of the dermal layer...
journal article 2021
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Egberts, G. (author), Vermolen, F.J. (author), van Zuijlen, Paul (author)
To deal with permanent deformations and residual stresses, we consider a morphoelastic model for the scar formation as the result of wound healing after a skin trauma. Next to the mechanical components such as strain and displacements, the model accounts for biological constituents such as the concentration of signaling molecules, the...
journal article 2021
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Peng, Q. (author), Vermolen, F.J. (author)
In this paper, we extend the model of wound healing by Boon et al. (J Biomech 49(8):1388–1401, 2016). In addition to explaining the model explicitly regarding every component, namely cells, signalling molecules and tissue bundles, we categorized fibroblasts as regular fibroblasts and myofibroblasts. We do so since it is widely documented that...
journal article 2020
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Koppenol, D.C. (author)
Dermal wounds are a significant global problem; although the treatment of these wounds has improved considerably over the last few decades, a treatment still does not result in a complete regeneration of the injured tissue. Instead, the final outcome of the healing process is scar tissue. The material properties of scar tissue are different from...
doctoral thesis 2017
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Koppenol, D.C. (author), Vermolen, F.J. (author), Koppenol-Gonzalez, Gabriela V. (author), Niessen, Frank B. (author), van Zuijlen, Paul P.M. (author), Vuik, Cornelis (author)
A continuum hypothesis-based model is developed for the simulation of the contraction of burns in order to gain new insights into which elements of the healing response might have a substantial influence on this process. Tissue is modeled as a neo-Hookean solid. Furthermore, (myo)fibroblasts, collagen molecules, and a generic signaling molecule...
journal article 2016
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Koppenol, D.C. (author), Vermolen, F.J. (author), Niessen, Frank B. (author), van Zuijlen, Paul P.M. (author), Vuik, Cornelis (author)
A continuum hypothesis-based, biomechanical model is presented for the simulation of the collagen bundle distribution-dependent contraction and subsequent retraction of healing dermal wounds that cover a large surface area. Since wound contraction mainly takes place in the dermal layer of the skin, solely a portion of this layer is included...
journal article 2016
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Vermolen, F.J. (author), Javierre, E. (author)
A simplified finite-element model for wound healing is proposed. The model takes into account the sequential steps of dermal regeneration, wound contraction, angiogenesis and wound closure. An innovation in the present study is the combination of the aforementioned partially overlapping processes, which can be used to deliver novel insights into...
journal article 2011
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