The Effect of Mechanical Strain on Non-enzymatic Cross-linking of Collagen type II Fibrils in Articular Cartilage

Investigations into mechanotransduction in connective tissue extracellular matrix (ECM) have demonstrated that collagen networks show cell-independent mechanosensitive behavior. It has been suggested that mechanical strain could lead to conformational changes in the molecular structure of collagen, thereby influencing the susceptibility to other...