The Effect of ECM Stiffness on Tip/Stalk Cell Patterning during Early Sprouting Angiogenesis: A computational approach

Angiogenesis, i.e. the formation of blood vessels from existing ones, plays a vital role in bone or wound healing. The expansion of vascularization facilitates the healing process through the delivery of oxygen and nutrients to the injured site and through the removal of waste products. Clinical observations indicate that impaired angiogenesis...

Assessing the effects of strontium releasing titanium implants on the behaviour of human umbilical vein endothelial cells

Introduction: Aseptic loosening of an orthopaedic implant due to the unsatisfactory attachment to the bone remains one of the most common reasons for failure of these implants. One of the possible approaches for improving the connection between the implanted biomaterial and the bone tissue being formed is the incorporation of bioactive agents...

Simulating sprouting angiogenesis: Using a new 3D substrate dependent cell-based model

Angiogenesis1 is the biological mechanism by which new blood vessels sprout from existing ones. It differs from vasculogenesis, which is the de novo growth of the primary vascular network from initially dispersed endothelial cells (ECs). Vasculogenesis is predominant in embryonic tissue whilst new vasculature in the adult body arises mostly from...

Modeling an angiogenesis treatment after a myocardial infarction

A serious complication that patients face after a heart attack is the formation of scar tissue at the damaged part of the heart. This scar leads to stiffening of the damaging region, and thereby it requires more perfomance of the heart muscle, which leads to fatigue and hence to failure and thereby causing immediate death of the patient. To...

A Mathematical Model for Tumor Growth and Angiogenesis

Mathematical modelling of angiogenesis and contraction occuring during wound healing in soft tissues

Wound contraction and angiogenesis are two important processes in the proliferative stage of wound healing. In this thesis a novel mathematical model on angiogenesis is presented. Furthermore this new angiogenesis model is coupled with an already existing model for wound contraction.