Searched for: subject%3A%22atherosclerosis%22
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Kurucz, Daniel (author)
Introduction: Atherosclerosis is characterised by the buildup of plaque within the arterial wall and it is often the underlying cause effect of deaths related to cardiovascular diseases. Thin cap fibroatheromas are plaques with a high risk of causing clinical events due to rupture and espousal of thrombogenic components to the bloodstream. The...
master thesis 2022
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De Miguel Muñoz, Pablo (author)
The rupture of atherosclerotic plaques present in vital arteries is the main trigger of fatal cardiovascular events, such as heart attacks and strokes. Plaque rupture is a mechanical failure of the fibrous plaque tissue that ensues upon large deformations of the tissue, induced by the blood pressure. Current knowledge on the rupture...
master thesis 2022
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Guvenir Torun, Su (author), Torun, Hakki M. (author), Hansen, Hendrik H.G. (author), de Korte, Chris L. (author), van der Steen, Antonius F.W. (author), Gijsen, F.J.H. (author), Akyildiz, A.C. (author)
Objective: Plaque rupture in atherosclerotic carotid arteries is a main cause of ischemic stroke and it is correlated with high plaque stresses. Hence, analyzing stress patterns is essential for plaque specific rupture risk assessment. However, the critical information of the multicomponent material properties of atherosclerotic carotid...
journal article 2022
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Moerman, A. M. (author), Korteland, S. (author), Dilba, K. (author), van Gaalen, K. (author), Poot, D. H.J. (author), van Der Lugt, A. (author), Verhagen, H. J.M. (author), Wentzel, J. J. (author), van Der Steen, A. F.W. (author), Gijsen, F.J.H. (author), Van der Heiden, K. (author)
The role of wall shear stress (WSS) in atherosclerotic plaque development is evident, but the relation between WSS and plaque composition in advanced atherosclerosis, potentially resulting in plaque destabilization, is a topic of discussion. Using our previously developed image registration pipeline, we investigated the relation between two...
journal article 2022
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Hengst, Madusha (author)
Atherosclerotic plaque rupture is the underlying cause of 50% of deaths in western society. Although screening methodologies exist, plaques are highly complex, and the parameters used to measure plaque vulnerability are often insufficient for correct medical screening. Since plaque rupture occurs when the vascular forces exceed the plaque...
master thesis 2021
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Swaab, Maarten (author)
Atherosclerosis is a cardiovascular disease in the arteries and a primary cause of death in the industrialized world. Most deaths due to atherosclerosis occur when the fibrous cap covering the necrotic core ruptures, leading to a blood clot. To determine whether an atherosclerotic plaque will rupture requires the development of accurate...
master thesis 2021
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Gijsen, F.J.H. (author), Vis, Bas (author), Barrett, Hilary E. (author), Zadpoor, A.A. (author), Verhagen, Hence J. (author), Bos, Daniel (author), van der Steen, A.F.W. (author), Akyildiz, A.C. (author)
Objective: Atherosclerotic plaque rupture in carotid arteries is a major source of cerebrovascular events. Calcifications are highly prevalent in carotid plaques, but their role in plaque rupture remains poorly understood. This work studied the morphometric features of calcifications in carotid plaques and their effect on the stress...
journal article 2021
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Guvenir Torun, Su (author), Torun, Hakki M. (author), Hansen, Hendrik H.G. (author), Gandini, Giulia (author), Berselli, Irene (author), Codazzi, Veronica (author), de Korte, Chris L. (author), van der Steen, A.F.W. (author), Migliavacca, Francesco (author), Chiastra, Claudio (author), Akyildiz, A.C. (author)
Atherosclerotic plaque rupture in coronary arteries, an important trigger of myocardial infarction, is shown to correlate with high levels of pressure-induced mechanical stresses in plaques. Finite element (FE) analyses are commonly used for plaque stress assessment. However, the required information of heterogenous material properties of...
journal article 2021
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Razzi, F. (author), Lovrak, M. (author), Gruzdyte, Dovile (author), Den Hartog, Yvette (author), Duncker, Dirk J. (author), van Esch, J.H. (author), van Steijn, V. (author), van Beusekom, Heleen M.M. (author)
Atherosclerotic arteries are commonly treated using drug-eluting stents (DES). However, it remains unclear whether and how the properties of atherosclerotic plaque affect drug transport in the arterial wall. A limitation of the currently used atherosclerotic animal models to study arterial drug distribution is the unpredictability of plaque...
journal article 2021
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Oversier, Rachel (author)
<b>Introduction:</b> Carotid atherosclerosis is characterized by the build-up of the so-called plaque tissue in the wall of the carotid artery. The rupture of carotid plaques can lead to acute manifestations, including ischemic stroke and transient ischaemic attack (TIA). The mechanism responsible for rupture is not yet unravelled, complicating...
master thesis 2020
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Tziotziou, Aikaterini (author)
Atherosclerosis is a prevalent cardiovascular disease and defined as plaque formation inside the arterial intima layer. The atherosclerotic plaque is characterized as anisotropic, soft tissue and a potential plaque rupture could result in life-threatening clinical events, such as ischemic attack or stroke. The plaque rupture mechanism is still...
master thesis 2020
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Gavriilidis, Prodromos (author)
Introduction: Atherosclerosis, the major source of cardiovascular diseases, is one of the leading causes of death. During atherosclerosis the arterial wall is affected by a complex process of lipid driven inflammation that leads to thickening of the arterial wall resulting in a so called plaque. Because of plaque growth, the lumen of the artery...
master thesis 2020
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Barrett, Hilary E. (author), Meester, Eric J. (author), van Gaalen, Kim (author), van der Heiden, Kim (author), Krenning, Boudewijn J. (author), Beekman, F.J. (author), Verhagen, H. J. (author), de Jong, M. (author), Gijsen, F.J.H. (author)
Purpose: Atherosclerotic plaque development and progression signifies a complex inflammatory disease mediated by a multitude of proinflammatory leukocyte subsets. Using single photon emission computed tomography (SPECT) coupled with computed tomography (CT), this study tested a new dual-isotope acquisition protocol to assess each radiotracer...
journal article 2020
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Vis, Bas (author)
Atherosclerotic plaque rupture is the main cause of acute myocardial infarction and stroke, the two leading causes of death worldwide. Rupture of plaque tissue is a mechanical event, where plaque stress or strain locally exceeds its strength. Biomechanical studies agree with histopathological findings that a large lipid pool and thin fibrous cap...
master thesis 2019
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Nouar, Amel (author)
Atherosclerosis, the chronic inflammation of the arterial wall, is one of the leading causes of death in the western societies. Which is characterized by the accumulation of inflammatory macrophages and necrotic regions in the intima. Rupture of the plaque can lead to thrombosis, a blood clot in the blood vessel, blocking the natural flow of the...
master thesis 2017
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Selwaness, Mariana (author), Hameeteman, Reinhard (author), Van 't Klooster, Ronald (author), Van den Bouwhuijsen, Quirijn (author), Hofman, Albert (author), Franco, Oscar H. (author), Niessen, W.J. (author), Klein, Stefan (author), Vernooij, Meike W. (author), Van der Lugt, Aad (author), Wentzel, Jolanda J. (author)
Background and aims In a large stroke-free population, we sought to identify cardiovascular risk factors and carotid plaque components associated with carotid plaque burden, lumen volume and stenosis. Methods The carotid arteries of 1562 stroke-free participants from The Rotterdam Study were imaged on a 1.5-Tesla MRI scanner. Inner and outer...
journal article 2016
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Visser, K.A. (author)
bachelor thesis 2015
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Van Velzen, B. (author)
Atherosclerosis is a progressive arterial disease in which fatty tissue accumulates in the arterial wall. Due to this lipid uptake, the artery thickens and can eventually rupture, causing the lipids to flow into the bloodstream and form blood clots. If this happens in the carotid arteries, which supply the head with oxygenated blood, a stroke...
master thesis 2015
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Nieuwstadt, H.A. (author), Van der Lugt, A. (author), Kassar, Z.A.M. (author), Breeuwer, M. (author), Van der Steen, A.F.W. (author), Gijsen, F.J.H. (author)
Carotid magnetic resonance imaging (MRI) is used to noninvasively assess atherosclerotic plaque fibrous cap (FC) status, which is closely related to ischemic stroke. Acquiring anisotropic voxels improves in-plane visualization, however, an oblique scan plane orientation could then obscure a FC (i.e., contrast below the noise level) and thus...
journal article 2014
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Jansen, K. (author), Van Soest, G. (author), Van der Steen, A.F.W. (author)
The vulnerable atherosclerotic plaque is believed to be at the root of the majority of acute coronary events. Even though the exact origins of plaque vulnerability remain elusive, the thin-cap fibroatheroma, characterized by a lipid-rich necrotic core covered by a thin fibrous cap, is considered to be the most prominent type of vulnerable plaque...
journal article 2014
Searched for: subject%3A%22atherosclerosis%22
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