- document
-
Straathof, Adrie J.J. (author)Microbial conversions are generally inhibited by their products. This product inhibition is particularly dependent on the product's hydrophobicity and on its acid dissociation behaviour, hence on pH. Dependence on the microbial strain is relatively modest according to many published data. Since product inhibition has various mechanistic...review 2023
- document
-
Strubbe, Laurence (author), van Dijk, E.J.H. (author), Deenekamp, Pascalle J.M. (author), van Loosdrecht, Mark C.M. (author), Volcke, Eveline I.P. (author)In the pursuit of reducing carbon footprint and in view of increasing energy prices, energy efficiency is more important than ever before. Batch-wise operated aerobic granular sludge reactors consume up to 50% less energy compared to conventional activated sludge systems because pumping energy is reduced and mixing equipment is not needed....journal article 2023
- document
-
Sterk, Merel (author)With (e-)grocery retailers striving to increase their efficiency and subsequently reduce their costs, the opportunities that lie in optimising the order picking process of the supply chain is of key importance. The complex nature of assigning articles to an optimal storage location, having efficient routing of order pickers, and optimised...master thesis 2022
- document
-
Emmerink, Jeroen (author)The Discrete Element Method (DEM) in combination with an One Factor At a Time (OFAT) experimental simulation plan were employed to investigate the effect of a selection of factors on the mixing performance of a double shaft, batch-type paddle mixer. Most influential factors on the mixing performance of the paddle mixer are desired for...master thesis 2022
- document
-
Lyu, Haozheng (author)Fine sieved fraction (FSF) is a solid waste generated from wastewater treatment plants (WWTPs). Cellulose fiber is the most important component of FSF, which can be fermented into volatile fatty acids (VFAs) and then be used as carbon sources in biological nutrient removal (BNR). This thesis measured and evaluated the aerobic & anaerobic...master thesis 2022
- document
-
van der Toorn, Eric (author)Next-Generation Sequencing (NGS) has made it possible to perform metagenomic sequencing of environmental microbiome samples. Colorectal cancer (CRC) benefits from early detection, and many studies find correlations between disease presence and abundance of species in samples of the microbiome. However, these studies are hard to reproduce and...master thesis 2022
- document
-
Coloma Hurel, J.L. (author), Teeuwisse, Lidwien (author), Afendi, Muhammad (author), Hagedoorn, P.L. (author), Hanefeld, U. (author)Granulicella tundricola hydroxynitrile lyase (GtHNL) catalyses the synthesis of chiral (R)‐ cyanohydrins and (R)‐β‐nitro alcohols. The triple variant GtHNL‐A40H/V42T/Q110H (GtHNL‐3V) was immobilised on Celite R‐633 and used in monophasic MTBE saturated with 100 mM KPi buffer pH 7 for the synthesis of (R)‐2‐nitro‐1‐phenylethanol (NPE) in batch...journal article 2022
- document
-
De Crescenzo, Carmen (author), Marzocchella, Antonia (author), Karatza, Despina (author), Molino, Antonio (author), Ceron Chafla, P.S. (author), Lindeboom, R.E.F. (author), van Lier, J.B. (author), Chianese, Simeone (author), Musmarra, Dino (author)Background: Pressurised anaerobic digestion allows the production of biogas with a high content of methane and, at the same time, avoid the energy costs for the biogas upgrading and injection into the distribution grid. The technology carries potential, but the research faces practical constraints by a.o. the capital investment needed in high...journal article 2022
- document
-
Picanço Castanheira Da Silva, T. (author), Eppink, Michel (author), Ottens, M. (author)Biopharmaceuticals are becoming increasingly important in modern healthcare. Monoclonal antibodies (mAb) are one of the most widely used therapeutic proteins and are important for the treatment of cancer and autoimmune diseases, among others. After cell culture there are still large amounts of other impurities (e.g. host cell proteins) in...journal article 2022
- document
-
de Hulster, A.F. (author), Mooiman, C. (author), Timmermans, Rowin (author), Mans, R. (author)Evolutionary engineering of microbes provides a powerful tool for untargeted optimization of (engineered) cell factories and identification of genetic targets for further research. Directed evolution is an intrinsically time-intensive effort, and automated methods can significantly reduce manual labor. Here, design considerations for various...journal article 2022
- document
-
Zhu, Yonghao (author), Hu, Yanjun (author), Guo, Qianqian (author), Zhao, Lingqin (author), Li, Lianming (author), Wang, Y. (author), Hu, Guixiang (author), Wibowo, Haryo (author), Di Maio, F. (author)One of the main challenges of bottom ash reutilization is heavy metal and salts' leaching potential. The effect of wet treatment on chemical composition and leaching toxicity of bottom ash were investigated in this study to mitigate this leaching potential. Batch leaching and column leaching tests were first conducted to investigate the...journal article 2022
- document
-
Totlani, K. (author)A crucial challenge during the initial stages of bioprocess development is that tools used to screen microorganisms and optimize cultivation conditions do not represent the environment imposed at industrial scale. Inside an industrial-scale bioreactor, microorganisms are often cultivated under fed-batch conditions, where nutrients are supplied...doctoral thesis 2021
- document
-
Smit, Jordi (author)Offline reinforcement learning, or learning from a fixed data set, is an attractive alternative to online reinforcement learning. Offline reinforcement learning promises to address the cost and safety implications of taking numerous random or bad actions online, which is a crucial aspect of traditional reinforcement learning that makes it...master thesis 2021
- document
-
Rajasekhar, Rajesh (author)The quality of a product is an important factor in the manufacturing industry. Maintaining a standard product quality ensures customer satisfaction and loyalty to the brand and reduces the risk and cost involved in the production. A system that reviews the product quality in production is the quality control system. Quality control ensures that...master thesis 2021
- document
-
Lamon, Julien (author)With an expectation of 8.3 trillion photos stored in 2021 [1], convolutional neural networks (CNN) are beginning to be preeminent in the field of image recognition. However, with this deep neural network (DNN) still being seen as a black box, it is hard to fully employ its capabilities. A need to tune hyperparameters is required to have a robust...bachelor thesis 2021
- document
-
Ansari, Ishtyaque Ahmed (author)Crystallization is an important process occurring in the nature, pharmaceutical, and food industries. It is one of many widely used unit operations for the separation and purification of chemicals industrially. Despite its far-reaching application in fine chemicals and active pharmaceutical ingredients production, the stochastic nature of...master thesis 2021
- document
-
Depaz, Lena (author)Medium chain length polyhydroxyalkanoate (mcl-PHA) is a form of polyhydroxyalkanoate (PHA) which has properties similar to rubber. However, most of the research on mcl-PHA has been focused on pure cultures with artificial substrates, both of which increase the cost of the production to economically unviable levels. This is especially the case...master thesis 2021
- document
-
Yu, W. (author), Mahfouz, A.M.E.T.A. (author), Reinders, M.J.T. (author)The power of single-cell RNA sequencing (scRNA-seq) in detecting cell heterogeneity or developmental process is becoming more and more evident every day. The granularity of this knowledge is further propelled when combining two batches of scRNA-seq into a single large dataset. This strategy is however hampered by technical differences between...journal article 2021
- document
-
Totlani, K. (author), Wang, Yen Chieh (author), Bisschops, Maxime (author), de Riese, Thorben (author), Kreutzer, M.T. (author), van Gulik, W.M. (author), van Steijn, V. (author)A key bottleneck in bioprocess development is that state-of-the-art tools used for screening of cells and optimization of cultivation conditions do not represent the conditions enforced at industrial scale. At industrial scale, cell growth is strictly controlled (“fed-batch”) to optimize the metabolites produced by the cells. In contrast,...journal article 2021
- document
-
Moreno Gonzalez, M. (author), Keulen, D. (author), Gomis-Fons, Joaquín (author), Lopez Gomez, M.G. (author), Nilsson, Bernt (author), Ottens, M. (author)Efficient recovery and utilization of valuable components from industrial food side streams is a main driver towards a circular economy. Among different available purification techniques, adsorption can effectively recover these components. However, the conventional batch mode of operation can limit its applicability in food processes due to...journal article 2021