Searched for: subject%3A%22biosensors%22
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Meng, X. (author), Ganapathy, S. (author), van Roemburg, Lars (author), Post, M.G. (author), Brinks, D. (author)
Voltage imaging using genetically encoded voltage indicators (GEVIs) has taken the field of neuroscience by storm in the past decade. Its ability to create subcellular and network level readouts of electrical dynamics depends critically on the kinetics of the response to voltage of the indicator used. Engineered microbial rhodopsins form a...
review 2023
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Zijlmans, Maarten (author)
Despite prostate cancer being the most prevalent type of cancer among males above the age of 55, nationalscreening programs are not conducted because of the high rate of false positives this would bring. This thesisintroduces surface acoustic wave sensors into the field of prostate cancer diagnosis which has the potential tomeasure the...
master thesis 2021
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Galiti, Danai (author)
Currently, preclinical drug testing and disease modelling are based on static cell cultures and animal models that often fail at predicting the human pathophysiology. Alternatively, Organ-on-Chips (OoCs), dynamic microphysiological platforms, can be employed to recapitulate organ functions and mimic the cell's microphysiological environment....
master thesis 2021
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Lehner, B. (author), Benz, D. (author), Moshkalev, Stanislav A. (author), Meyer, Anne S. (author), Cotta, Monica A. (author), Janissen, R. (author)
Graphene oxide (GO) has immense potential for widespread use in diverse in vitro and in vivo biomedical applications owing to its thermal and chemical resistance, excellent electrical properties and solubility, and high surface-to-volume ratio. However, development of GO-based biological nanocomposites and biosensors has been hampered by its...
journal article 2021
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Heiles, B.G. (author), Terwiel, D. (author), Maresca, D. (author)
Ultrasound imaging is one of the most widely used modalities in clinical practice, revealing human prenatal development but also arterial function in the adult brain. Ultrasound waves travel deep within soft biological tissues and provide information about the motion and mechanical properties of internal organs. A drawback of ultrasound...
review 2021
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Aydogmus, H. (author), van Ginkel, H.J. (author), Galiti, Anna-Danai (author), Hu, Michel (author), Frimat, Jean-Philippe (author), van den Maagdenberg, Arn (author), Zhang, Kouchi (author), Mastrangeli, Massimo (author), Sarro, Pasqualina M (author)
Continuous monitoring of tissue microphysiology is a key enabling feature of the organ-on-chip (OoC) approach for drug screening and disease modeling. Sensing charged species in OoC tissue microenvironments is thereby essential. However, the inherently small (i.e., cm) size of OoC devices poses the challenging requirement to integrate...
conference paper 2021
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Fragasso, A. (author), Schmid, S. (author), Dekker, C. (author)
Nanopores bear great potential as single-molecule tools for bioanalytical sensing and sequencing, due to their exceptional sensing capabilities, high-throughput, and low cost. The detection principle relies on detecting small differences in the ionic current as biomolecules traverse the nanopore. A major bottleneck for the further progress of...
review 2020
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Berlin, Shai (author), Carroll, E.C.M. (author)
contribution to periodical 2020
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D'Ambrosio, Vasil (author), Dore, Eleonora (author), Di Blasi, Roberto (author), van den Broek, M.A. (author), Sudarsan, Suresh (author), Horst, Jolanda ter (author), Ambri, Francesca (author), Keasling, Jay D. (author), Mans, R. (author)
Engineering living cells for production of chemicals, enzymes and therapeutics can burden cells due to use of limited native co-factor availability and/or expression burdens, totalling a fitness deficit compared to parental cells encoded through long evolutionary trajectories to maximise fitness. Ultimately, this discrepancy puts a selective...
journal article 2020
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Hubbe, H.M.K. (author), Mendes, E. (author), Boukany, P. (author)
Polymer nanowire-related research has shown considerable progress over the last decade. The wide variety of materials and the multitude of well-established chemical modifications have made polymer nanowires interesting as a functional part of a diagnostic biosensing device. This review provides an overview of relevant publications addressing...
review 2019
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Holovchenko, A. (author)
This thesis describes the research directed towards practical realization of an on-chip biosensing technology and that of understanding charge transport mechanisms in organic and biological nanoobjects. For this, silicon-based chips with metallic nanoelectrodes were fabricated using electron-beam lithography and metal evaporation. The final...
doctoral thesis 2017
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Boelsma, C. (author), Bannenberg, L.J. (author), Van Setten, M. J. (author), Steinke, N.J. (author), van Well, A.A. (author), Dam, B. (author)
Hydrogen detection is essential for its implementation as an energy vector. So far, palladium is considered to be the most effective hydrogen sensing material. Here we show that palladium-capped hafnium thin films show a highly reproducible change in optical transmission in response to a hydrogen exposure ranging over six orders of magnitude...
journal article 2017
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Janissen, R. (author), Sahoo, Prasana K. (author), Santos, Clelton A. (author), Da Silva, Aldeliane M. (author), Von Zuben, Antonio A.G. (author), Souto, Denio E.P. (author), Costa, Alexandre D.T. (author), Celedon, Paola (author), Zanchin, Nilson I.T. (author), Almeida, Diogo B. (author), Oliveira, Douglas S. (author)
Electrically active field-effect transistors (FET) based biosensors are of paramount importance in life science applications, as they offer direct, fast, and highly sensitive label-free detection capabilities of several biomolecules of specific interest. In this work, we report a detailed investigation on surface functionalization and...
journal article 2017
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Smit, B. (author)
Conductive polymers such as polyaniline, polypyrrole and PEDOT (poly(3,4-ethylenedioxythiophene)) have been used extensively to enhance the sensitivity, versatility and biocompatibility of electrochemical- and biosensors. Both their electrochemical stability and their mechanical properties make them highly suitable for applications that require...
master thesis 2016
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Heerema, S.J. (author), Dekker, C. (author)
Fast, cheap, and reliable DNA sequencing could be one of the most disruptive innovations of this decade, as it will pave the way for personalized medicine. In pursuit of such technology, a variety of nanotechnology-based approaches have been explored and established, including sequencing with nanopores. Owing to its unique structure and...
journal article 2016
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Ullien, D. (author)
This thesis covers work done on silicon nanowire field effect transistors and optical microring resonators. An effort was put to develop point-of-care devices based on this platforms to facilitate rapid and reliable diagnosis of influenza A.
doctoral thesis 2015
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Van 't Hof, S.A. (author)
Colorectal anastomotic leakage is one of the most feared complications after colorectal surgery and is associated with increased morbidity, prolonged hospital stay and risk of local cancer reoccurrence. One out of ten anastomoses leak, leading to infections. Colorectal anastomotic leakage is currently diagnosed by sniffing and watching drain...
master thesis 2014
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Hall, Drew A. (author), Gaster, Richard S. (author), Makinwa, K.A.A. (author), Wang, Shan X. (author), Murmann, Boris (author)
Magnetic nanotechnologies have shown significant potential in several areas of nanomedicine such as imaging, therapeutics, and early disease detection. Giant magnetoresistive spin-valve (GMR SV) sensors coupled with magnetic nanotags (MNTs) possess great promise as ultra-sensitive biosensors for diagnostics. We report an integrated sensor...
journal article 2013
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Rassaei, L. (author), Cui, J. (author), Goluch, E.D. (author), Lemay, S.G. (author)
Despite the broad use of enzymes in electroanalytical biosensors, the influence of enzyme kinetics on the function of prototype sensors is often overlooked or neglected. In the present study, we employ amperometry as an alternative or complementary method to study the kinetics of tyrosinase, whose catalytic activity results in o-quinone products...
journal article 2012
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Janssen, O.T.A. (author)
In the next decade, several applications of nanotechnology will change our lives. LED lighting is about to replace the common light bulb. The main advantages are its energy efficiency and long lifetime. LEDs can be much more efficient, when part of the emitted light that is currently trapped in the device, could be radiated out of the device....
doctoral thesis 2010
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