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Forman, Jack (author), Pataranutaporn, Pat (author), Gough, Phillip (author), Kim, Raphael (author), Bell, Fiona (author), Ofer, Netta (author), Lu, Jasmine (author), Vujic, Angela (author), Bai, Muqing (author)As knowledge around bio-digital interaction continues to unfold, there are new opportunities for HCI researchers to integrate biology as a design and computational material. Our motivation for the workshop is to bring together interdisciplinary researchers with interest in exploring the next generation of biological HCI and exploring novel...conference paper 2023
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Vermeer, C.M. (author)Polyhydroxyalkanoates (PHA) are a family of biopolymers produced intracellular<br/>by a range of different bacteria.PHA have attracted widespread attention as<br/>an environmental friendly replacement of fossil-based polymers, because they<br/>have thermoplastic and/or elastomeric properties, and are also biobased and<br/>biodegradable.Moreover,...doctoral thesis 2022
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Lip, K.Y.F. (author)Saccharomyces yeasts are common workhorses for the production of alcoholic beverage and bio-ethanol. In these production processes, temperature is one of the predominant factors determining the operational costs of the industrial fermentation processes and the quality of the products (alcoholic beverage) because it influences the functioning of...doctoral thesis 2022
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Bouchaut, B.F.H.J. (author), Hollmann, F. (author), Asveld, L. (author)The increasing societal demand for safer, biobased products, and processes<br/>creates opportunities for industrial biotechnology and chemistry. To succeed,<br/>controlled learning about new emerging risks is crucial but both fields endure<br/>difficulty in doing so by their respective regulation and risk management culture.journal article 2022
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Hinrichs-Krapels, S. (author), Ditewig, Bor (author), Boulding, Harriet (author), Chalkidou, Anastasia (author), Erskine, Jamie (author), Shokraneh, Farhad (author)Objectives To systematically review academic literature for studies on any processes, procedures, methods or approaches to purchasing high-cost medical devices and equipment within hospitals in high-income countries. Methods On 13 August 2020, we searched the following from inception: Cost-Effectiveness Analysis Registry, EconLit and ProQuest...review 2022
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Freese, M. (author), Tiemersma, S.A. (author), Verbraeck, A. (author)As part of a Dutch Science Foundation project called T-TRIPP, the authors developed the serious game Cards for Biosafety. The aim of Cards for Biosafety is to let young biotechnology researchers learn more about biosafety. Analyses of workshops with researchers from the biotechnology domain as well as results of interviews with several biosafety...conference paper 2022
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Doornenbal, Eline (author)The R&D productivity crisis is among the most pressing issues in the drug industry. The increasing costs and stable R&D outputs jeopardise the industry’s economic health, drug innovation, and the accessibility and affordability of medicines. The pharmaceutical R&D productivity problem is expected to be diminished due to...master thesis 2021
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Perli, T. (author), Vos, A.M. (author), Bouwknegt, J. (author), Dekker, W.J.C. (author), Wiersma, S.J. (author), Mooiman, C. (author), Ortiz Merino, R.A. (author), Daran, J.G. (author), Pronk, J.T. (author)Neocallimastigomycetes are unique examples of strictly anaerobic eukaryotes. This study investigates how these anaerobic fungi bypass reactions involved in synthesis of pyridine nucleotide cofactors and coenzyme A that, in canonical fungal pathways, require molecular oxygen. Analysis of Neocallimastigomycetes proteomes identified a candidate...journal article 2021
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Bouchaut, B.F.H.J. (author), Asveld, L. (author), Hanefeld, U. (author), Vlierboom, A.C.E. (author)Although both the Inherent Safety Principles (ISPs) and the Safe-by-Design (SbD) approach revolve around the central value of safety, they have a slightly different focus in terms of developing add-on features or considering initial design choices. This paper examines the differences between these approaches and analyses which approach is more...journal article 2021
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Barata-Antunes, Cláudia (author), Alves, Rosana (author), Talaia, Gabriel (author), Casal, Margarida (author), Gerós, Hernâni (author), Mans, R. (author), Paiva, Sandra (author)Plasma membrane transporters play pivotal roles in the import of nutrients, including sugars, amino acids, nucleobases, carboxylic acids, and metal ions, that surround fungal cells. The selective removal of these transporters by endocytosis is one of the most important regulatory mechanisms that ensures a rapid adaptation of cells to the...review 2021
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Dekker, W.J.C. (author), Ortiz Merino, R.A. (author), Kaljouw, Astrid (author), Battjes, Julius (author), Wiering, Frank W. (author), Mooiman, C. (author), de la Torre, P. (author), Pronk, J.T. (author)Current large-scale, anaerobic industrial processes for ethanol production from renewable carbohydrates predominantly rely on the mesophilic yeast Saccharomyces cerevisiae. Use of thermotolerant, facultatively fermentative yeasts such as Kluyveromyces marxianus could confer significant economic benefits. However, in contrast to S. cerevisiae,...journal article 2021
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Cerruti, M. (author), Stevens, B. (author), Ebrahimi, S. (author), Alloul, A. (author), Vlaeminck, Siegfried E. (author), Weissbrodt, D.G. (author)Mixed-culture biotechnologies are widely used to capture nutrients from wastewater. Purple non-sulfur bacteria (PNSB), a guild of anoxygenic photomixotrophic organisms, rise interest for their ability to directly assimilate nutrients in the biomass. One challenge targets the aggregation and accumulation of PNSB biomass to separate it from the...journal article 2020
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Bouchaut, B.F.H.J. (author), Asveld, L. (author)Advanced gene editing techniques such as Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/Cas have increased the pace of developments in the field of industrial biotechnology. Such techniques imply new possibilities when working with living organisms, possibly leading to uncertain risks. In the Netherlands, current policy fails...journal article 2020
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Weusthuis, Ruud A. (author), Folch, Pauline L. (author), Pozo-Rodríguez, Ana (author), Paul, C.E. (author)Fermentation processes are used to sustainably produce chemicals and as such contribute to the transition to a circular economy. The maximum theoretical yield of a conversion can only be approached if all electrons present in the substrate end up in the product. Control over the electrons is therefore crucial. However, electron transfer via...review 2020
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Gorter de Vries, A.R. (author)Lager beer, also referred to as Pilsner, is the most popular alcoholic beverage in the world, with an annual consumption of almost 200 billion litres per year. To make lager beer, brewer’s wort is fermented with the yeast <i style="mso-bidi-font-style:normal"...doctoral thesis 2019
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Meerstadt, Charlotte (author)As freshwater resources are predicted to become more scarce in the future, desalination will become a more prevalent treatment method. Microbial desalination, defined as the use of microbial processes to remove ions from a saline solution, may have potential as a new desalination method to produce water for domestic, agricultural or industrial...master thesis 2019
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Edmunds, Laurel D. (author), Gluderer, Silvia (author), Ovseiko, Pavel V. (author), Kamerling, R. (author), Ton, Jacqueline (author), Vis, Laura (author), Jenni, Mario (author), Tutton, Gregory (author), Lawton-Smith, Helen (author)Background: While the European Union is striving to become the 'Innovation Union', there remains a lack of quantifiable indicators to compare and benchmark regional innovation clusters. To address this issue, a HealthTIES (Healthcare, Technology and Innovation for Economic Success) consortium was funded by the European Union's Regions of...journal article 2019
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Straathof, Adrie J.J. (author), Wahl, S.A. (author), Benjamin, Kirsten R. (author), Takors, Ralf (author), Wierckx, Nick (author), Noorman, H.J. (author)Future manufacturing will focus on new, improved products as well as on new and enhanced production methods. Recent biotechnological and scientific advances, such as CRISPR/Cas and various omic technologies, pave the way to exciting novel biotechnological research, development, and commercialization of new sustainable products. Rigorous...review 2019
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Verhoeven, M.D. (author)The recent start-up of several full-scale ‘second generation’ ethanol plants marks a major milestone in the development of Saccharomyces cerevisiae yeast strains for fermentation of lignocellulosic hydrolysates of agricultural residues and energy crops. In contrast to the fermentation of hexose sugar-rich substrates, such as corn syrup or sugar...doctoral thesis 2018
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Papapetridis, I. (author), Verhoeven, M.D. (author), Wiersma, S.J. (author), Goudriaan, M. (author), van Maris, A.J.A. (author), Pronk, J.T. (author)Simultaneous fermentation of glucose and xylose can contribute to improved productivity and robustness of yeast-based processes for bioethanol production from lignocellulosic hydrolysates. This study explores a novel laboratory evolution strategy for identifying mutations that contribute to simultaneous utilisation of these sugars in batch...journal article 2018