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Gorter de Vries, A.R. (author)Lager beer, also referred to as Pilsner, is the most popular alcoholic beverage in the world, with an annual consumption of almost 200 billion litres per year. To make lager beer, brewer’s wort is fermented with the yeast <i style="mso-bidi-font-style:normal"...doctoral thesis 2019
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Meerstadt, Charlotte (author)As freshwater resources are predicted to become more scarce in the future, desalination will become a more prevalent treatment method. Microbial desalination, defined as the use of microbial processes to remove ions from a saline solution, may have potential as a new desalination method to produce water for domestic, agricultural or industrial...master thesis 2019
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Edmunds, Laurel D. (author), Gluderer, Silvia (author), Ovseiko, Pavel V. (author), Kamerling, R. (author), Ton, Jacqueline (author), Vis, Laura (author), Jenni, Mario (author), Tutton, Gregory (author), Lawton-Smith, Helen (author)Background: While the European Union is striving to become the 'Innovation Union', there remains a lack of quantifiable indicators to compare and benchmark regional innovation clusters. To address this issue, a HealthTIES (Healthcare, Technology and Innovation for Economic Success) consortium was funded by the European Union's Regions of...journal article 2019
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Straathof, Adrie J.J. (author), Wahl, S.A. (author), Benjamin, Kirsten R. (author), Takors, Ralf (author), Wierckx, Nick (author), Noorman, H.J. (author)Future manufacturing will focus on new, improved products as well as on new and enhanced production methods. Recent biotechnological and scientific advances, such as CRISPR/Cas and various omic technologies, pave the way to exciting novel biotechnological research, development, and commercialization of new sustainable products. Rigorous...review 2019
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Verhoeven, M.D. (author)The recent start-up of several full-scale ‘second generation’ ethanol plants marks a major milestone in the development of Saccharomyces cerevisiae yeast strains for fermentation of lignocellulosic hydrolysates of agricultural residues and energy crops. In contrast to the fermentation of hexose sugar-rich substrates, such as corn syrup or sugar...doctoral thesis 2018
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Papapetridis, I. (author), Verhoeven, M.D. (author), Wiersma, S.J. (author), Goudriaan, M. (author), van Maris, A.J.A. (author), Pronk, J.T. (author)Simultaneous fermentation of glucose and xylose can contribute to improved productivity and robustness of yeast-based processes for bioethanol production from lignocellulosic hydrolysates. This study explores a novel laboratory evolution strategy for identifying mutations that contribute to simultaneous utilisation of these sugars in batch...journal article 2018
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Ling, Chen (author), Qiao, Guan Qing (author), Shuai, Bo Wen (author), Olavarria, Karel (author), Yin, Jin (author), Xiang, Rui Juan (author), Song, Kun Nan (author), Shen, Yun Hao (author), Guo, Yingying (author), Chen, G. (author)Halomonas bluephagenesis has been developed as a platform strain for the next generation industrial biotechnology (NGIB) with advantages of resistances to microbial contamination and high cell density growth (HCD), especially for production of polyhydroxyalkanoates (PHA) including poly(3-hydroxybutyrate) (PHB), poly(3-hydroxybutyrate-co-4...journal article 2018
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Jansen, Mickel L.A. (author), Bracher, J.M. (author), Papapetridis, I. (author), Verhoeven, M.D. (author), de Bruijn, J.A. (author), de Waal, P. (author), van Maris, A.J.A. (author), Klaassen, P (author), Pronk, J.T. (author)The recent start-up of several full-scale ‘second generation’ ethanol plants marks a major milestone in the development of Saccharomyces cerevisiae strains for fermentation of lignocellulosic hydrolysates of agricultural residues and energy crops. After a discussion of the challenges that these novel industrial contexts impose on yeast strains,...journal article 2017
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Castle, S. (author)Synthetic biology is the cutting-edge field of designing biological systems to perform as genetically-engineered technology capable of useful tasks. It has huge potential for many revolutionary applications. These include the development of smart medicine - such as bacteria programmed to seek out and destroy cancer cells [Chakravarti, 2015], or...master thesis 2016
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Nemati, M. (author), Loozen, G.B. (author), Van der Wekken, N. (author), Van de Belt, G. (author), Urbach, H.P. (author), Bhattacharya, N. (author), Kenjeres, S. (author)A preliminary comparative measurement between particle imaging velocimetry (PIV) and laser speckle contrast analysis (LASCA) to study pulsatile flow using ventricular assist device in a patient-specific carotid artery phantom is reported. These full-field optical techniques have both been used to study flow and extract complementary parameters....journal article 2015
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Van Lier, J.B. (author), Van der Zee, F.P. (author), Frijters, C.T.M.J. (author), Ersahin, M.E. (author)In the last 40 years, anaerobic sludge bed reactor technology evolved from localized lab-scale trials to worldwide successful implementations at a variety of industries. High-rate sludge bed reactors are characterized by a very small foot print and high applicable volumetric loading rates. Best performances are obtained when the sludge bed...journal article 2015
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Lemmens, E. (author), Jansen, M. (author)This bachelor thesis describes the development of a sensor system for measuring the cell concentration in small bio-reactors. The study was conducted at Delft University of Technology on behalf of Applikon Biotechnology B.V. The MicroMatrix of Applikon is used for experimental determination of the optimal conditions for bioprocesses in...bachelor thesis 2014
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Van den Hoorn, J.C. (author), Van der Kemp, J.W.F. (author)This thesis describes a bachelor graduation project of the study Electrical Engineering at Delft University of Technology. The purpose of this project is to develop an impedance sensor that can measure the cell concentration in a micro-bioreactor. This bioreactor will be used to investigate the optimal cell growth conditions of a cell culture....bachelor thesis 2014
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Zhang, F. (author), Zhang, Y. (author), Ding, J. (author), Dai, K. (author), Van Loosdrecht, M.C.M. (author), Zeng, R.J. (author)The control of metabolite production is difficult in mixed culture fermentation. This is particularly related to hydrogen inhibition. In this work, hydrogenotrophic methanogens were selectively enriched to reduce the hydrogen partial pressure and to realize efficient acetate production in extreme-thermophilic (706C) mixed culture fermentation....journal article 2014
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Nemati, M. (author), Presura, C.N. (author), Urbach, H.P. (author), Bhattacharya, N. (author)Continuous health monitoring has become a major theme of our aging society. Portable devices play an important role here. Many optical portable devices are susceptible to motion induced artifacts. We have performed an experimental study for detection of fluid pulsation based on multi-exposure speckle images, in presence of motion induced...journal article 2014
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Das, V.L. (author)The pharmaceutical industry has been spending an increasing amount of money on R&D over the years. However, fewer drugs have been approved by the FDA and the EMA recently. This lack in innovation performance is a problem which needs to be solved in order to continue finding medicines for cureless diseases. Innovation lies at the heart of the...master thesis 2014
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Nijkamp, J.F. (author)Microorganisms are employed on a large scale in a variety of industrial production processes, such as production of food and ingredients, beverages, pharmaceutical compo- nents and fine- and bulk chemicals. Improving the behaviour of these microorganisms is of crucial importance in the design of efficient production processes. In this thesis we...doctoral thesis 2013
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Huisjes, E.H. (author)The ambition to reduce our current dependence on fossil transportation fuels has driven renewed interest in bioethanol. Pectin-rich feedstocks like sugar beet pulp and citrus peel, which are currently sold as cattle feed, are promising raw materials for the production of bioethanol. This thesis explores the challenges related to the fermentation...doctoral thesis 2013
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- Straathof, A.J.J. (author) journal article 2013
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Goel, A. (author), Wortel, M.T. (author), Molenaar, D. (author), Teusink, B. (author)Performance of industrial microorganisms as cell factories is limited by the capacity to channel nutrients to desired products, of which optimal production usually requires careful manipulation of process conditions, or strain improvement. The focus in process improvement is often on understanding and manipulating the regulation of metabolism....journal article 2012