Modulating the inflammatory phenotype of monocyte-derived dendritic cells using osmolality in 3D microenvironments

Delayed healing or non-union of bone fractures are still clinically and economically relevant problems. Bone healing includes pro- and anti-inflammatory phases, which proved crucial for successful healing. Being able to modulate these inflammatory responses could potentially promote bone fracture healing. Dendritic cells play important roles in...

Developing a microfluidic device incorporating submicron topographies for studying bone regeneration

A major challenge facing the study of bone regeneration today is the inability to mimic the tissue microenvironment and the factors comprising it. Organ-on-chip based microfluidic systems today aim at doing so by dynamically culturing living cells in them. These are preferred owing to their small feature sizes, laminar flows, high throughput,...

Development of a Two-Phase Scaffold-Nanoparticle System for the Sustained Delivery of Growth Factors in Bone Tissue Engineering Applications

In recent years, bone tissue engineering has emerged as a promising strategy to overcome the limitations of current ‘gold standard’ treatment options for bone disorders such as bone autografts and allografts. Bone tissue engineering strategies rely on the development of a scaffold that mimics the extracellular matrix, thereby providing an...

Permeability and mechanical properties of triply periodic minimal surface scaffolds for bone regeneration

Scaffolds for bone regeneration have been investigated as bone substitutes in critical sized bone defects. It is known that the architecture of these scaffolds is important for the bone regeneration process, which depends on cell response and vascular ingrowth into the scaffold. With advanced fabrication techniques, such as selective laser...