Searched for: subject%3A%22brachytherapy%22
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van Oossanen, R. (author), Maier, A. (author), Godart, Jérémy (author), Pignol, Jean Philippe (author), Denkova, A.G. (author), van Rhoon, Gerard C. (author), Djanashvili, K. (author)
Objective: To investigate the potential of hybrid Pd/Fe-oxide magnetic nanoparticles designed for thermo-brachytherapy of breast cancer, considering their specific loss power (SLP) and clinical constraints in the applied magnetic field. Methods: Hybrid nanoparticles consisting of palladium-core and iron oxide shell of increasing thickness,...
journal article 2024
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Straathof, R. (author), Meijaard, J.P. (author), Perez, S.M. (author), Kolkman-Deurloo, Inger Karine K. (author), Nout, Remi A. (author), Heijmen, Ben J.M. (author), Wauben, L.S.G.L. (author), Dankelman, J. (author), van de Berg, N.J. (author)
Background: The steep radiation dose gradients in cervical cancer brachytherapy (BT) necessitate a thorough understanding of the behavior of afterloader source cables or needles in the curved channels of (patient-tailored) applicators. Purpose: The purpose of this study is to develop and validate computer models to simulate: (1) BT source...
journal article 2024
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Pool, Lotte (author)
Brachytherapy is a type of internal radiation therapy that is used to treat cervical cancer. It involves the application of a radioactive source in close proximity to the tumour. This can be done either by directly inserting the source into (or close to) the tumour using interstitial hollow needles, or by loading the source into an intracavitary...
master thesis 2023
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Bouter, P.A. (author)
In recent years, the use of Artificial Intelligence (AI) has become prevalent in a large number of societally relevant, real-world problems, e.g., in the domains of engineering and health care. The field of Evolutionary Computation (EC) can be considered to be a sub-field of AI, concerning optimization using Evolutionary Algorithms (EAs), which...
doctoral thesis 2023
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de Vries, M. (author), Wijntjes, M. (author), Sikorski, J. (author), Moreira, P. (author), van de Berg, N.J. (author), van den Dobbelsteen, J.J. (author), Misra, S. (author)
Conformity of tumour volumes and dose plans in prostate brachytherapy (BT) can be constrained by unwanted needle deflections, needle access restrictions and visualisation limitations. This work validates the feasibility of teleoperated robotic control of an active steerable needle using magnetic resonance (MR) for guidance. With this system,...
journal article 2023
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van Krimpen, Eline (author)
Treatment of early stage breast cancer is generally invasive to a patient's daily life while being treated. Therefore, to diminish the physical and psychological impact during and after recovery, a newly proposed minimally invasive therapy for early-stage breast cancer treatment is proposed. Within this study, this proposed treatment is modelled...
master thesis 2022
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Sickler, Hanna (author)
Prostate cancer is the most frequently diagnosed cancer type among men, and the third deathliest form of cancer. Several treatments are available to treat prostate cancer. Low Dose Rate Brachytherapy (LDR BT) is one of them, which inserts permanent radioactive seeds into the prostate using a needle. The literature review performed prior to this...
master thesis 2022
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Bakker, Matthias (author)
master thesis 2022
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Scholman, Renzo (author)
Even if a Multi-modal Multi-Objective Evolutionary Algorithm (MMOEA) is designed to find all locally optimal approximation sets of a Multi-modal Multi-objective Optimization Problem (MMOP), there is a risk that the found approximation sets are not smoothly navigable because the solutions belong to various niches, which reduces the insight for...
master thesis 2022
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Cruijsen, Pep (author)
High dose-rate (HDR) brachytheraphy (BT) is radiation therapy (RT) which temporarily inserts a highly radioactive source into the planning target volume (PTV) with the use of an afterloader, applicator, transfer tubes, needles and planning software. The dose delivered to a point in the tumour depends on the type and activity of the source, the...
master thesis 2022
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Androulakis, Ioannis (author), Mestrom, Rob M.C. (author), Christianen, Miranda E.M.C. (author), Kolkman‐deurloo, Inger Karine K. (author), van Rhoon, G.C. (author)
The combination of interstitial hyperthermia treatment (IHT) with high dose rate brachytherapy (HDR‐BT) can improve clinical outcomes since it highly enhances the efficiency of cell kill, especially when applied simultaneously. Therefore, we have developed the ThermoBrachy applicators. To effectively apply optimal targeted IHT, treatment...
journal article 2022
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Androulakis, Ioannis (author), Mestrom, Rob M.C. (author), Christianen, Miranda E.M.C. (author), Kolkman-Deurloo, Inger Karine K. (author), van Rhoon, G.C. (author)
In high-dose-rate brachytherapy (HDR-BT) for prostate cancer treatment, interstitial hyperthermia (IHT) is applied to sensitize the tumor to the radiation (RT) dose, aiming at a more efficient treatment. Simultaneous application of HDR-BT and IHT is anticipated to provide maximum radiosensitization of the tumor. With this rationale, the...
journal article 2022
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van Oossanen, R. (author), Godart, Jeremy (author), Brown, J.M.C. (author), Maier, A. (author), Pignol, Jean-Philippe (author), Denkova, A.G. (author), Djanashvili, K. (author), van Rhoon, G.C. (author)
Background: Treatment of early-stage breast cancer currently includes surgical removal of the tumor and (partial) breast irradiation of the tumor site performed at fractionated dose. Although highly effective, this treatment is exhaustive for both patient and clinic. In this study, the theoretical potential of an alternative treatment combining...
journal article 2022
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Commandeur, Joost (author)
In this thesis BRIGHT, a multi-objective evolutionary algorithm for the creation of treatment plans for high-dose rate brachytherapy for prostate cancer, is extended with a new objective to mitigate the formation of high dose contiguous volumes, i.e. hotspots. Multiple new objectives are tested on their performance to reduce hotspots, while...
master thesis 2021
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Straathof, Robin (author)
Brachytherapy (BT) is an essential component in the treatment of cervical cancer as it allows for locally delivering a high dose to the tumour with minimal trauma to surrounding tissues and organs at risk (OARs). However, in advanced cervical cancer patients commercially available BT applicators are particularly ill-adapted and therefore result...
master thesis 2021
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Somerwil, Flip (author)
The goal of this study is to create a phantom which can be used to test strategies for sealing the vaginal cavity, so that ultrasound gel can be used to fill the vaginal cavity improve the visibility of the vaginal cavity in MR-images.<br/>Silicone rubber and PolyVinyl Alcohol (PVA) were tested, to check whether their mechanical properties can...
master thesis 2021
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de Vries, M. (author), Klaassen, N. J.M. (author), Morsink, N. C. (author), van Nimwegen, S. A. (author), Nijsen, J. F.W. (author), van den Dobbelsteen, J.J. (author)
Microbrachytherapy with radioactive holmium-166 (166Ho) microspheres (MS) has the potential to be an effective treatment method for brain malignancies. Direct intratumoural delivery of 166Ho-MS and dose coverage of the whole tumour are crucial requirements. However, currently no dedicated instruments for controlled intratumoural delivery...
journal article 2021
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Veldman, Ellen (author)
Prostate cancer is the most frequently diagnosed type of cancer among males. Brachytherapy has become a common treatment for this disease. In this form of radiotherapy, sealed radiation sources are placed through a implant catheters inside the prostate. This treatment affects the tumor cells locally and reduces damage to healthy tissues. However...
master thesis 2020
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Nobel, Max (author)
Prostate cancer is the most common cancer in men and third in terms of mortality. High dose rate brachytherapy is a common and effective treatment to treat this cancer. High dose rate brachytherapy requires the implantation of several needles into the prostate trough which a radiation source is introduced. This implantation can present a number...
master thesis 2020
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Oud, Michelle (author), Kolkman-Deurloo, Inger Karine (author), Mens, J.W. (author), Lathouwers, D. (author), Perko, Z. (author), Heijmen, Ben (author), Breedveld, Sebastiaan (author)
Purpose: To develop and evaluate a fast, automated multi-criterial treatment planning approach for adaptive high-dose-rate (HDR) intracavitary + interstitial brachytherapy (BT) for locally advanced cervical cancer. Methods and materials: Twenty-two previously delivered single fraction MRI-based HDR treatment plans (SF<sub>clin</sub>) were...
journal article 2020
Searched for: subject%3A%22brachytherapy%22
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