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Keulen, Bart (author)Introduction: Congenital diaphragmatic hernia (CDH) is a rare developmental defect of the diaphragm characterised by herniation of abdominal organs into the thoracic cavity during prenatal development. This herniation is usually accompanied by pulmonary hypertension (PH) and cardiac dysfunction (CD). Although several parameters are known to...master thesis 2023
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Joy, Denzil (author)Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels.<br/>CVDs are the leading cause of death worldwide. To diagnose and treat CVDs, clinicians and cardiologists use multiple noninvasive imaging techniques. These scans are used to segment certain structures of the heart. Deep learning-based cardiac segmentation...master thesis 2023
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Ferreira, Vanessa M. (author), Plein, Sven (author), Wong, T.C. (author), Tao, Q. (author), Raisi-Estabragh, Zahra (author), Jain, Supriya S. (author), Han, Yuchi (author), Ojha, Vineeta (author), Kim, Jiwon (author)Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic that has affected nearly 600 million people to date across the world. While COVID-19 is primarily a respiratory illness, cardiac injury is also known to occur. Cardiovascular magnetic resonance (CMR) imaging is uniquely capable of characterizing myocardial tissue properties in...review 2023
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Kolawole, Fikunwa O. (author), Peirlinck, M. (author), Cork, Tyler E. (author), Levenston, Marc (author), Kuhl, Ellen (author), Ennis, Daniel B. (author)Impaired cardiac filling in response to increased passive myocardial stiffness contributes to the pathophysiology of heart failure. By leveraging cardiac MRI data and ventricular pressure measurements, we can estimate in vivo passive myocardial stiffness using personalized inverse finite element models. While it is well-known that this...journal article 2023
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Teh, Irvin (author), Shelley, David (author), Boyle, J.H. (author), Zhou, Fenglei (author), Poenar, Ana Maria (author), Sharrack, Noor (author), Foster, Richard J. (author), Yuldasheva, Nadira Y. (author), Parker, Geoff J.M. (author)Purpose: Tensor-valued diffusion encoding can probe more specific features of tissue microstructure than what is available by conventional diffusion weighting. In this work, we investigate the technical feasibility of tensor-valued diffusion encoding at high b-values with q-space trajectory imaging (QTI) analysis, in the human heart in vivo....journal article 2023
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Rivera-Arbeláez, José M. (author), Keekstra, Danjel (author), Cofiño-Fabres, Carla (author), Boonen, Tom (author), Dostanic, M. (author), ten Den, Simone A. (author), Vermeul, Kim (author), Mastrangeli, Massimo (author), van den Berg, A (author)The high rate of drug withdrawal from the market due to cardiovascular toxicity or lack of efficacy, the economic burden, and extremely long time before a compound reaches the market, have increased the relevance of human in vitro models like human (patient-derived) pluripotent stem cell (hPSC)-derived engineered heart tissues (EHTs) for the...journal article 2023
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Raeis Ghanavati, Parastou (author)The number of cardiac patients (people with heart problems) is growing all the time. Given that any person who encounters a cardiac condition should undergo cardiac rehabilitation (CR), a program to rehabilitate the heart and learn to manage it in daily life, it is expected that the health system will also grow exponentially in order to meet the...master thesis 2022
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Chan, Megan (author)Space Mission Sanitas is a game-based health intervention to help cardiac patients maintain their physical activity level after cardiac rehabilitation. Often people find it hard to maintain their physical activity level after cardiac rehabilitation. They face different barriers that lower their motivation, resulting in an unhealthy lifestyle...master thesis 2022
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Kos, Cees (author)The heart is one of our vital organs. It functions by periodically contracting in a rhythmic way. Sometimes, this rhythmic behaviour is affected by abnormalities in the tissue. These conditions are referred to as cardiac arrhythmias. One kind is of specific interest, called atrial fibrillation (AF). To further study AF, methods have been...master thesis 2022
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Mulder, Larissa (author)In the Netherlands, 362.000 people suffered from atrial fibrillation in 2019. During a catheter intervention, the tissue that causes atrial fibrillation is destroyed by heat generated by an alternating current exerted from an ablation catheter. Two problems of this treatment are over-ablation of the heart tissue and the non-contingent...master thesis 2022
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Jongeneel, Hilda (author)The growing demand for cardiovascular treatments and the need to control the ever rising health care expenditures require efficient use of expensive resources, such as cardiac catheterization laboratories (cath labs). These in cardiac catheterization specialized operating rooms are labor and capital-intensive. Therefore, a high utilization is...master thesis 2022
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Tenbult, Nicole (author), Kraal, J.J. (author), Brouwers, Rutger (author), Spee, Ruud (author), Eijsbouts, Sabine (author), Kemps, Hareld (author)Background: Atrial fibrillation is commonly associated with obesity. Observational studies have shown that weight loss is associated with improved prognosis and a decrease in atrial fibrillation frequency and severity. However, despite these benefits, nonadherence to lifestyle programs is common. Objective: In this study, we evaluated adherence...journal article 2022
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- Brouwers, Rutger W.M. (author), Kemps, Hareld M.C. (author), Herkert, Cyrille (author), Peek, Niels (author), Kraal, J.J. (author) journal article 2022
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Weingärtner, S.D. (author), Demirel, Omer Burak (author), Gama, Francisco. (author), Pierce, Iain (author), Treibel, Thomas A. (author), Schulz-Menger, Jeanette (author), Akcakaya, Mehmet (author)Late gadolinium enhancement (LGE) with cardiac magnetic resonance (CMR) imaging is the clinical reference for assessment of myocardial scar and focal fibrosis. However, current LGE techniques are confined to imaging of a single cardiac phase, which hampers assessment of scar motility and does not allow cross-comparison between multiple phases....journal article 2022
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Demirel, Omer Burak (author), Yaman, Burhaneddin (author), Shenoy, Chetan (author), Moeller, Steen (author), Weingärtner, S.D. (author), Akçakaya, Mehmet (author)Purpose: To develop a physics-guided deep learning (PG-DL) reconstruction strategy based on a signal intensity informed multi-coil (SIIM) encoding operator for highly-accelerated simultaneous multislice (SMS) myocardial perfusion cardiac MRI (CMR). Methods: First-pass perfusion CMR acquires highly-accelerated images with dynamically varying...journal article 2022
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de Groot, N.M.S. (author), Shah, Dipen (author), Boyle, Patrick M. (author), Anter, Elad (author), Clifford, Gari D. (author), Deisenhofer, Isabel (author), van Dessel, Pascal (author), Dilaveris, Polychronis (author), van der Veen, A.J. (author)We aim to provide a critical appraisal of basic concepts underlying signal recording and processing technologies applied for (i) atrial fibrillation (AF) mapping to unravel AF mechanisms and/or identifying target sites for AF therapy and (ii) AF detection, to optimize usage of technologies, stimulate research aimed at closing knowledge gaps,...journal article 2022
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Peirlinck, M. (author), Yao, J. (author), Sahli Costabal, F. (author), Kuhl, E. (author)Many drugs interact with ion channels in the cells of our heart and trigger heart rhythm disorders with potentially fatal consequences. Computational modeling can provide mechanistic insight into the onset and propagation of drug-induced arrhythmias, but the effect of drugs on the mechanical performance of the heart remains poorly understood....journal article 2022
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St. Pierre, Sarah R. (author), Peirlinck, M. (author), Kuhl, Ellen (author)Cardiovascular disease in women remains under-diagnosed and under-treated. Recent studies suggest that this is caused, at least in part, by the lack of sex-specific diagnostic criteria. While it is widely recognized that the female heart is smaller than the male heart, it has long been ignored that it also has a different microstructural...review 2022
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Zhang, Z. (author), Wu, Chenming (author), Dai, C. (author), Shi, Qingqing (author), Fang, G. (author), Xie, Dongfang (author), Zhao, Xiangjie (author), Liu, Yong Jin (author), Wang, C.C. (author), Wang, Xiu Jie (author)Despite the recent advances in artificial tissue and organ engineering, how to generate large size viable and functional complex organs still remains as a grand challenge for regenerative medicine. Three-dimensional bioprinting has demonstrated its advantages as one of the major methods in fabricating simple tissues, yet it still faces...journal article 2022
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Kordes, Arthur (author)Atrial Fibrillation affects millions of people worldwide. It is associated with an impaired quality of life and an increased risk of stroke, cardiac failure and mortality. Treatments exist, but early detection and treatment is crucial, due to the progressive nature of the disease. Algorithms can help with early detection. Machine learning...master thesis 2021