Mesenchymal stem/stromal cells-derived extracellular vesicles as a potentially more beneficial therapeutic strategy than MSC-based treatment in a mild metabolic osteoarthritis model

Background: Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) hold promise as a disease modifying treatment in osteoarthritis (OA). Obesity, and its associated inflammation, contribute to OA development and metabolic OA represents a specific and significant group of the OA patient population. Given their...

Bioprinting of Zonal Cartilage Scaffolds Using Different Cell Densities: A biomimetic approach on cartilage regeneration

The use of allografts for the treatment of critical size cartilage defects holds disadvantages including the limited number of donors and the compromised chondrocyte viability. These limitations have prompted researchers to explore different options, such as cartilage engineering. Bioprinting, a promising tissue engineering technique, could be...

A Novel Tool for the Detection of Osteochondral Defects in the Ankle Joint

Introduction. Ultrasound is known for cheap, fast and non-invasive diagnosis of numerous injuries. Sport-related injuries in the ankle joint and rehabilitation after surgical intervention are badly diagnosable using traditional ultrasound. Bones surrounding the surface of the articular cartilage blocks the ultrasound pulse and hides the talar...