Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration

OBJECTIVE: To identify OA subtypes based on cartilage transcriptomic data in cartilage tissue and characterize their underlying pathophysiological processes and/or clinically relevant characteristics. METHODS: This study includes n = 66 primary OA patients (41 knees and 25 hips), who underwent a joint replacement surgery, from which...

A method for metropolitan landscape characterization: Case study Rotterdam

This paper presents a theoretical and methodological framework for a comprehensive landscape characterization, focussing on the largest and most complex urban realm: the metropolitan region. Landscape character has in recent years emerged as a new paradigm to understand, monitor and evaluate cultural landscapes undergoing change. The scope of...