Searched for: subject%3A%22collagen%22
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Jansen, Imke (author), Cahalane, Rachel (author), Hengst, Ranmadusha (author), Akyildiz, A.C. (author), Farrell, Eric (author), Gijsen, F.J.H. (author), Aikawa, Elena (author), van der Heiden, Kim (author), Wissing, Tamar (author)
The rupture of an atherosclerotic plaque cap overlying a lipid pool and/or necrotic core can lead to thrombotic cardiovascular events. In essence, the rupture of the plaque cap is a mechanical event, which occurs when the local stress exceeds the local tissue strength. However, due to inter- and intra-cap heterogeneity, the resulting ultimate...
review 2024
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Giubertoni, Giulia (author), Feng, Liru (author), Klein, Kevin (author), Giannetti, Guido (author), Rutten, Luco (author), van der Net, J.J.P. (author), Castro Linares, G. (author), Koenderink, G.H. (author), Woutersen, Sander (author)
Water is known to play an important role in collagen self-assembly, but it is still largely unclear how water-collagen interactions influence the assembly process and determine the fibril network properties. Here, we use the H[Formula: see text]O/D[Formula: see text]O isotope effect on the hydrogen-bond strength in water to investigate the...
journal article 2024
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Egberts, G. (author)
Burns can make patients’ lives quite miserable. Apart from prominent and thickened, or hypertrophic, scars, the skin may be characterized by contraction. When this contraction is so severe that the patient loses joint mobility, it is called contracture. Then a patient may have difficulties with sports or other daily activities. The consequence...
doctoral thesis 2023
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De Miguel Muñoz, Pablo (author)
The rupture of atherosclerotic plaques present in vital arteries is the main trigger of fatal cardiovascular events, such as heart attacks and strokes. Plaque rupture is a mechanical failure of the fibrous plaque tissue that ensues upon large deformations of the tissue, induced by the blood pressure. Current knowledge on the rupture...
master thesis 2022
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Eren, E. Deniz (author), Nijhuis, Wouter H. (author), van der Weel, Freek (author), Dede Eren, Aysegul (author), Ansari, Sana (author), Bomans, Paul H.H. (author), Friedrich, Heiner (author), Sakkers, Ralph J. (author), Weinans, Harrie (author), de With, Gijsbertus (author)
Bone is a complex natural material with a complex hierarchical multiscale organization, crucial to perform its functions. Ultrastructural analysis of bone is crucial for our understanding of cell to cell communication, the healthy or pathological composition of bone tissue, and its three-dimensional (3D) organization. A variety of techniques...
journal article 2022
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Nijhuis, Wouter (author), Verhoef, Marjolein (author), van Bergen, Christiaan (author), Weinans, Harrie (author), Sakkers, Ralph (author)
Fractures in patients with osteogenesis imperfecta (OI) are caused by a decreased strength of bone due to a decreased quality and quantity of bone matrix and architecture. Mutations in the collagen type 1 encoding genes cause the altered formation of collagen type I, one of the principal building blocks of bone tissue. Due to the complexity...
journal article 2022
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Swaab, Maarten (author)
Atherosclerosis is a cardiovascular disease in the arteries and a primary cause of death in the industrialized world. Most deaths due to atherosclerosis occur when the fibrous cap covering the necrotic core ruptures, leading to a blood clot. To determine whether an atherosclerotic plaque will rupture requires the development of accurate...
master thesis 2021
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Bhattarai, Abhisek (author), Mäkelä, Janne T.A. (author), Pouran, Behdad (author), Kröger, Heikki (author), Weinans, Harrie (author), Grinstaff, Mark W. (author), Töyräs, Juha (author), Turunen, Mikael J. (author)
Contrast-enhanced computed tomography is an emerging diagnostic technique for osteoarthritis. However, the effects of increased water content, as well as decreased collagen and proteoglycan concentrations due to cartilage degeneration, on the diffusion of cationic and nonionic agents, are not fully understood. We hypothesize that for a...
journal article 2021
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de Jong, Yoni (author)
Introduction. To prevent burns from scar formation and contraction, the use of splinting therapy in the early phase of wound healing is considered as an effective non-surgical method. Splinting entails the application of a mechanical load in the opposite direction of the contractile force within the wound, based on the assumption that wound- or...
master thesis 2019
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Mansoor, Amal (author)
Atherosclerosis is an inflammatory disease characterised by the formation of plaque in the intimal layer of the artery. The plaque is made of a lipid rich necrotic core which is covered by a collagen rich fibrous cap. If this fibrous cap ruptures, it can lead to sudden thrombotic occlusion of the artery. Rupture of the fibrous cap is linked to...
master thesis 2019
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Lagrand, Jaap (author)
Investigations into mechanotransduction in connective tissue extracellular matrix (ECM) have demonstrated that collagen networks show cell-independent mechanosensitive behavior. It has been suggested that mechanical strain could lead to conformational changes in the molecular structure of collagen, thereby influencing the susceptibility to other...
master thesis 2019
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Verhagen, Mathijs (author)
Cancer metastasis, the spread of cancer to distant organs, is the major cause of cancerrelated mortality. Hence, understanding the mechanisms underlying cancer metastasis is crucial to improve clinical interventions. Despite intensive efforts, the driving mechanisms remain ill-understood due to the difficulties posed by studying the different...
master thesis 2019
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Nijhuis, W.A. (author), Eastwood, D. M. (author), Allgrove, J. (author), Hvid, I. (author), Weinans, Harrie (author), Bank, R. A. (author), Sakkers, R. J. (author)
The majority of patients with osteogenesis imperfecta (OI) have mutations in the COL1A1 or COL1A2 gene, which has consequences for the composition of the bone matrix and bone architecture. The mutations result in overmodified collagen molecules, thinner collagen fibres and hypermineralization of bone tissue at a bone matrix level. Trabecular...
journal article 2019
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Tan Timur, Ufuk (author), Caron, Marjolein (author), van den Akker, Guus (author), van der Windt, Anna (author), Visser, Jenny (author), van Rhijn, Lodewijk (author), Weinans, Harrie (author), Welting, Tim (author), Emans, Pieter (author), Jahr, H. (author)
During standard expansion culture (i.e., plasma osmolarity, 280 mOsm) human articular chondrocytes dedifferentiate, making them inappropriate for autologous chondrocyte implantation to treat cartilage defects. Increasing the osmolarity of culture media to physiological osmolarity levels of cartilage (i.e., 380 mOsm), increases collagen type...
journal article 2019
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Smit, Stefan (author)
Osteogenesis imperfecta (OI), also known as brittle bone disease, affects 1 in 10.000 births. This disease is characterized by skeletal dysplasias, bone fragility and many secondary health issues. It is a heritable disorder affecting collagen type I, which is an essential protein in bone tissue. Post-translational overmodifications in collagen...
master thesis 2018
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Pouran, B. (author), Moshtagh, Parisa R. (author), Arbabi, V. (author), Snabel, Jessica (author), Stoop, Reinout (author), Ruberti, Jeffrey (author), Malda, Jos (author), Zadpoor, A.A. (author), Weinans, Harrie (author)
An important aspect in cartilage ageing is accumulation of advanced glycation end products (AGEs) after exposure to sugars. Advanced glycation results in cross-links formation between the collagen fibrils in articular cartilage, hampering their flexibility and making cartilage more brittle. In the current study, we investigate whether...
journal article 2018
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Spiesz, E.M. (author), Thorpe, Chavaunne T. (author), Thurner, Philipp J. (author), Screen, Hazel R.C. (author)
Structure-function relationships in tendons are directly influenced by the arrangement of collagen fibres. However, the details of such arrangements in functionally distinct tendons remain obscure. This study demonstrates the use of quantitative polarised light microscopy (qPLM) to identify structural differences in two major tendon...
journal article 2018
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Koppenol, D.C. (author)
Dermal wounds are a significant global problem; although the treatment of these wounds has improved considerably over the last few decades, a treatment still does not result in a complete regeneration of the injured tissue. Instead, the final outcome of the healing process is scar tissue. The material properties of scar tissue are different from...
doctoral thesis 2017
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Calkoen, H.G.M. (author)
The structural response of active skeletal muscle is derived from a combination of sarcomere contraction properties, collagen fibres in the connective tissue, and incompressibility. The role of collagen tissues could be substantial but is still not completely understood. Only few studies have looked into the functionality of collagen...
master thesis 2016
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Andriakopoulou, C. (author)
Collagen gels hold great promise in the field of tissue engineering as collagen is highly biocompatible, biodegradable, abundant in nature and it provides an optimum environment for tissue regeneration and restoration of normal tissue function. However, collagen hydrogels have poor mechanical strength due to low collagen proportion and thus are...
master thesis 2016
Searched for: subject%3A%22collagen%22
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