Searched for: subject%3A%22decellularization%22
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van Beek, Marije (author)
Cholangiocarcinoma (CCA) is a rare but aggressive type of primary liver cancer with a dismal prognosis. CCA commonly metastasizes to the lungs and lymph nodes, significantly reducing overall survival. However, a mechanistic understanding of how CCA invades these metastatic sites remains lacking. This is partly due to the failure of current...
master thesis 2023
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van Tienderen, Gilles S. (author), van Beek, M.E.A. (author), Schurink, Ivo J. (author), Rosmark, Oskar (author), Roest, Henk P. (author), Demmers, J.A.A. (author), Muntz, I.A.A. (author), Conboy, J.P. (author), Koenderink, G.H. (author)
Cholangiocarcinoma (CCA) is a type of liver cancer with an aggressive phenotype and dismal outcome in patients. The metastasis of CCA cancer cells to distant organs, commonly lung and lymph nodes, drastically reduces overall survival. However, mechanistic insight how CCA invades these metastatic sites is still lacking. This is partly because...
journal article 2023
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van Tienderen, Gilles S. (author), Conboy, J.P. (author), Muntz, I.A.A. (author), Willemse, Jorke (author), Tieleman, Jantine (author), Monfils, Kathryn (author), Schurink, Ivo J. (author), Demmers, J.A.A. (author), Koenderink, G.H. (author)
Tumor initiation and progression are critically dependent on interaction of cancer cells with their cellular and extracellular microenvironment. Alterations in the composition, integrity, and mechanical properties of the extracellular matrix (ECM) dictate tumor processes including cell proliferation, migration, and invasion. Also in primary...
journal article 2023
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van Hoeven, Michiel (author)
This research addresses the following question: Is it possible to detect vascular obstructions and oedemas or monitor the decellularization process in perfused ex-vivo porcine kidneys using electrical impedance spectroscopy? Patients on the waiting list for kidney transplantation die because of a kidney shortage. A part of this problem can be...
master thesis 2022
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van Dis, Daniëlle (author)
Purpose: Patients with tracheal lesions that exceed half of the trachea’s total length require a tracheal substitute. Tissue engineering, using either synthetic materials or decellularized tracheal tissue, opens up new possibilities for generating tracheal substitutes. Decellularization, a procedure in which the tissue's...
master thesis 2021
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