Applying hybrid evolutionary algorithms to deformable image registration of 3D medical images using common B-spline-based transformation models

Deformable Image Registration (DIR) is a medical imaging process involving the spatial alignment of two or more images using a transformation model that can account for non-rigid deformations. B-spline-based transformation models have emerged as a common approach to express such spatial alignments. However, without additional measures, their...

Optimal Mixing Evolutionary Algorithms for Large-Scale Real-Valued Optimization: Including Real-World Medical Applications

In recent years, the use of Artificial Intelligence (AI) has become prevalent in a large number of societally relevant, real-world problems, e.g., in the domains of engineering and health care. The field of Evolutionary Computation (EC) can be considered to be a sub-field of AI, concerning optimization using Evolutionary Algorithms (EAs), which...

Automatic landmark correspondence detection in medical images with an application to deformable image registration

Purpose: Deformable image registration (DIR) can benefit from additional guidance using corresponding landmarks in the images. However, the benefits thereof are largely understudied, especially due to the lack of automatic landmark detection methods for three-dimensional (3D) medical images. Approach: We present a deep convolutional neural...

Robust contour propagation using deep learning and image registration for online adaptive proton therapy of prostate cancer

Purpose: To develop and validate a robust and accurate registration pipeline for automatic contour propagation for online adaptive Intensity-Modulated Proton Therapy (IMPT) of prostate cancer using elastix software and deep learning. Methods: A three-dimensional (3D) Convolutional Neural Network was trained for automatic bladder segmentation...

Designing the Real-Valued Gene-pool Optimal Mixing Evolutionary Algorithm and Applying it to Substantially Improve the Efficiency of Multi-Objective Deformable Image Registration

The recently introduced Gene-pool Optimal Mixing Evolutionary Algorithm (GOMEA) for discrete variables has been shown to be able to efficiently and effectively exploit the decomposability of optimization problems, especially in a grey-box setting, in which a solution can be efficiently updated after a modification of a subset of its variables....