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Zhang, Lu (author), van Schie, M.S. (author), Xiang, Hongxian (author), Liao, Rongheng (author), Zheng, Jiahao (author), Knops, Paul (author), Taverne, Yannick J.H.J. (author), de Groot, N.M.S. (author)(1) Background: Structural remodeling plays an important role in the pathophysiology of atrial fibrillation (AF). It is likely that structural remodeling occurs transmurally, giving rise to electrical endo-epicardial asynchrony (EEA). Recent studies have suggested that areas of EEA may be suitable targets for ablation therapy of AF. We...journal article 2024
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van Breukelen, Elena (author)For the heart to pump blood throughout the body, electrical impulses that trigger the cellular contraction must be generated and spread through the myocardial tissue. These signals propagate faster along the longitudinal cardiac fiber direction than the transverse direction, conferring the heart with anisotropic conduction properties. Therefore,...master thesis 2023
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Suresan, Anjali (author)Atrial Fibrillation (AF) is a cardiac arrhythmia that occurs due to the initiation of electrical impulses in the heart in an uncoordinated manner, giving rise to a disorganized and rapid heartbeat. The progression of AF over time can lead to complications such as stroke and heart failure. Catheter ablation is an established treatment protocol...master thesis 2023
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Rodewijk, Koen (author)Atrial fibrillation (AF) is the most commonly occurring arrhythmia in clinical practice and can have a significant impact on the current and future wellbeing of the patient. By placing an unipolar sensor array directly on the epicardium during an open-heart surgery to measure the electrical activity of the atrium, more insight about this disease...master thesis 2023
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Zhang, Lu (author), van Schie, Mathijs S. (author), Knops, Paul (author), Taverne, Yannick J.H.J. (author), de Groot, N.M.S. (author)Objective: Patients with persistent atrial fibrillation (AF) have more electrical endo-epicardial asynchrony (EEA) during sinus rhythm (SR) than patients without AF. Prior mapping studies indicated that particularly unipolar, endo- and/or epicardial electrogram (EGM) morphology may be indicators of EEA. This study aim to develop a novel...journal article 2023
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Rout, Samprajani (author), Monna, G.L.E. (author), Pareschi, Fabio (author), Setti, Gianluca (author), Serdijn, W.A. (author)The key challenges in designing a multi-channel biosignal acquisition system for an ambulatory or invasive medical application with a high channel count are reducing the power consumption, area consumption and the outgoing wire count. This article proposes a spread-spectrum modulated biosignal acquisition system using a shared amplifier and...journal article 2023
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Hunter, William (author)Atrial fibrillation is a common cardiovascular disease, affecting the regular beating of the heart through chaotic contraction of the heart's upper chambers. On its own, the condition—increasingly prevalent among the elderly—is not life threatening, but it leads to an increased risk of stroke and heart failure. As of yet, there is no consensus...master thesis 2022
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Sun, M. (author)Atrial fibrillation (AF) is a frequently encountered cardiac arrhythmia characterized by rapid and irregular atrial activity, which increases the risk of strokes, heart failure and other heart-related complications. The mechanisms of AF are complicated. Although various mechanisms were proposed in previous research, the precise mechanisms of AF...doctoral thesis 2022
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Moree, Tijs (author)The most common serious heart rhythm disease is atrial fibrillation. It is not fatal on its own but does increase the risk of heart failures and strokes. There is little understanding about the mechanisms behind the disease, so more insight is desired. Using an array of electrodes, measurements are being performed of the electrical atrial...master thesis 2022
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Abdi, Bahareh (author)Atrial fibrillation (AF) is a common age-related cardiac arrhythmia. AF is characterized by rapid and irregular electrical activity of the heart leading to a higher risk of stroke and heart failure. During AF, the upper chambers of the heart, called atria, experience chaotic electrical wave propagation. However, despite the various mechanisms...doctoral thesis 2021
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van Twist, Eris (author)Background: Unipolar electrograms (U-EGMs) contain additional information about interatrial activation and conduction in their morphology, which may aid towards improved diagnosis and staging of atrial fibrillation (AF).Objective: The primary objective is to investigate regional differences in electrogram area (EA) during SR and AF and to design...master thesis 2021
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Sun, M. (author), de Groot, N.M.S. (author), Hendriks, R.C. (author)Impaired electrical conduction has been shown to play an important role in the development of heart rhythm disorders. Being able to determine the conductivity is important to localize the arrhythmogenic substrate that causes abnormalities in atrial tissue. In this work, we present an algorithm to estimate the conductivity from epicardial...journal article 2021
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Abdi, Bahareh (author), van Schie, Mathijs S. (author), de Groot, N.M.S. (author), Hendriks, R.C. (author)Background: Atrial electrograms recorded from the epicardium provide an important tool for studying the initiation, perpetuation, and treatment of AF. However, the properties of these electrograms depend largely on the properties of the electrode arrays that are used for recording these signals. Method: In this study, we use the electrode's...journal article 2021
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Kolling, B. (author), Abdi, Bahareh (author), Groot, N.M.S. de (author), Hendriks, R.C. (author)Atrial electrograms are often used to gain understanding on the development of atrial fibrillation (AF). Using such electrograms, cardiologists can reconstruct how the depolarization wave-front propagates across the atrium. Knowing the exact moment at which the depolarization wavefront in the tissue reaches each electrode is an important aspect...conference paper 2020
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Abdi, Bahareh (author), Hendriks, R.C. (author), van der Veen, A.J. (author), de Groot, N.M.S. (author)Background: Local activation time (LAT) annotation in unipolar electrograms is complicated by interference from nonlocal atrial activities of neighboring tissue. This happens due to the spatial blurring that is inherent to electrogram recordings. In this study, we aim to exploit multi-electrode electrogram recordings to amplify the local...journal article 2020
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Kölling, Bart (author)A common cardiac arrhythmia is atrial fibrillation, which is becoming more widespread worldwide. Currently there is some understanding about the mechanisms behind atrial fibrillation, however more insight into the conduction of the atrial tissue is desired. Therefore, invasive mapping studies have been performed where an array of electrodes is...master thesis 2019
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Das, Aurojyoti (author), Rout, S. (author), Urso, A. (author), Serdijn, W.A. (author)This paper presents a novel multichannel level-crossing (MLC) ADC architecture aimed at recording atrial electrograms from multiple channels. The proposed architecture combines synchronous sampling with level-crossing (LC) quantisation to achieve activity dependent operation while recording from multiple channels simultaneously. In the...conference paper 2019
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Abdi, Bahareh (author), Hendriks, R.C. (author), van der Veen, A.J. (author), de Groot, Natasja M.S. (author)Finding the hidden parameters of the cardiac electrophysiological model would help to gain more insight on the mechanisms underlying atrial fibrillation, and subsequently, facilitate the diagnosis and treatment of the disease in later stages. In this work, we aim to estimate tissue conductivity from recorded electrograms as an indication of...journal article 2019
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Abdi, Bahareh (author), Hendriks, R.C. (author), van der Veen, A.J. (author), de Groot, N.M.S. (author)Diagnosis and treatment of atrial fibrillation can benefit from various signal processing approaches employed on atrial electrograms. However, the performance and interpretation of these approaches get highly degraded by far-field ventricular activities (VAs) that distort the morphology of the pure atrial activities (AAs). In this study, we...conference paper 2019
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Maswan, Jelimo (author)Atrial fibrillation (AF) is one of the more common clinical arrhythmias with a high morbidity and mortality. Despite this, the electrophysiological and pathological mechanisms associated with AF largely remain a mystery, encouraging the use of ever more sophisticated techniques to extract vital information for diagnostic and therapeutic purposes...master thesis 2017