Microbial lifelines in bioprocesses: From concept to application

Bioprocesses are scaled up for the production of large product quantities. With larger fermenter volumes, mixing becomes increasingly inefficient and environmental gradients get more prominent than in smaller scales. Environmental gradients have an impact on the microorganism's metabolism, which makes the prediction of large-scale performance...

Assessing the European Electric-Mobility Transition: Emissions from Electric Vehicle Manufacturing and Use in Relation to the EU Greenhouse Gas Emission Targets

The European Union (EU) has set a 37.5% GHG reduction target in 2030 for the mobility sector, relative to 1990 levels. This requires increasing the share of zero-emission passenger vehicles, mainly in the form of electric vehicles (EVs). This study calculates future GHG emissions related to passenger vehicle manufacturing and use based on...

Multi-omic analyses in immune cell development with lessons learned from T cell development

Traditionally, flow cytometry has been the preferred method to characterize immune cells at the single-cell level. Flow cytometry is used in immunology mostly to measure the expression of identifying markers on the cell surface, but—with good antibodies—can also be used to assess the expression of intracellular proteins. The advent of single...

Microfluidics meets 3D cancer cell migration

An early step of metastasis requires a complex and coordinated migration of invasive tumor cells into the surrounding tumor microenvironment (TME), which contains extracellular matrix (ECM). It is being appreciated that 3D matrix-based microfluidic models have an advantage over conventional in vitro and animal models to study tumor...

Environmental flow assessment and implications on sustainability of aquatic ecosystems in Ethiopia: A literature review on global and national evidences

As part of water resources management policy, water resources projects undertake environmental flow assessments (EFA) to determine how much water should be maintained or released to the downstream part of rivers to protect the health of aquatic and riparian ecosystems and societal wellbeing. In Ethiopia, EFA is being undertaken mostly in...

Recent advances in understanding the flow over bluff bodies with different geometries at moderate Reynolds numbers

The application of unsteady incompressible flow phenomenon over the bluff bodies has received the attention of many researchers due to the rich and complex physics underpinning these flows, and thus requiring special attention in their modelling and numerical simulations. The wake that forms at the leeside of the bluff body is of particular...

Traffic Flow on a Ring with a Single Autonomous Vehicle: An Interconnected Stability Perspective

In recent years, field experiments have been performed on ring roadways with human-driven vehicles or with a mix of human-driven and autonomous vehicles. While these experiments demonstrate the potential for controlling traffic flows by a small number of autonomous vehicles, the theoretical framework about such a possibility is to a large...

A review of the methods of modeling multi-phase flows within different microchannels shapes and their applications

In industrial processes, the microtechnology concept refers to the operation of small devices that integrate the elements of operational and reaction units to save energy and space. The advancement of knowledge in the field of microfluidics has resulted in fabricating devices with different applications in micro and nanoscales. Micro-and nano...

Individual wave overtopping at coastal structures: A critical review and the existing challenges

Conventionally, allowable mean overtopping discharge is used as a design criterion for coastal structures. The mean overtopping discharge needs to be limited to ensure structural stability as well as the safety of people, vehicles, and properties behind the structure. Nowadays, limits for the maximum individual overtopping volumes are also...

Plasma synthetic jet actuators for active flow control

The plasma synthetic jet actuator (PSJA), also named as sparkjet actuator, is a special type of zero-net mass flux actuator, driven thermodynamically by pulsed arc/spark discharge. Compared to widely investigated mechanical synthetic jet actuators driven by vibrating diaphragms or oscillating pistons, PSJAs exhibit the unique capability of...

Geothermal energy in deep aquifers: A global assessment of the resource base for direct heat utilization

In this paper we present results of a global resource assessment for geothermal energy within deep aquifers for direct heat utilization. Greenhouse heating, spatial heating, and spatial cooling are considered in this assessment. We derive subsurface temperatures from geophysical data and apply a volumetric heat-in-place method to improve...