Searched for: subject%3A%22gene%255C%2Bexpression%22
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Godino, E. (author)
The Christophe Danelon lab is involved in the long-term effort to construct an autonomous minimal cell using a bottom-up approach. Our goal is to achieve self-maintenance, selfreproduction, and evolution of a liposome compartment containing a minimal genome and a cell-free gene expression system. Self-reproduction requires splitting of the...
doctoral thesis 2022
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Blanken, D.M. (author)
Cells, the building blocks of life, are vastly complex. This complexity confers to every living organism the ability to maintain oneself, reproduce oneself, and evolve. Creating a minimal system from nonliving components that is capable of self-maintenance, self-reproduction, and evolvability, will greatly increase our understanding of life....
doctoral thesis 2021
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Kattan, J.M. (author), Doerr, A. (author), Dogterom, A.M. (author), Danelon, C.J.A. (author)
Genetic control over a cytoskeletal network inside lipid vesicles offers a potential route to controlled shape changes and DNA segregation in synthetic cell biology. Bacterial microtubules (bMTs) are protein filaments found in bacteria of the genus Prosthecobacter. They are formed by the tubulins BtubA and BtubB, which polymerize in the...
journal article 2021
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Ragusi, Max A.A. (author), Bismeijer, Tycho (author), van der Velden, Bas H.M. (author), Loo, Claudette E. (author), Canisius, Sander (author), Wesseling, Jelle (author), Wessels, L.F.A. (author), Elias, Sjoerd G. (author), Gilhuijs, Kenneth G.A. (author)
Purpose: To assess whether contralateral parenchymal enhancement (CPE) on MRI is associated with gene expression pathways in ER+/HER2-breast cancer, and if so, whether such pathways are related to survival. Methods: Preoperative breast MRIs were analyzed of early ER+/HER2-breast cancer patients eligible for breast-conserving surgery included...
journal article 2021
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Bauduin, S.E.E.C. (author), den Rooijen, I.L.B. (author), Meijer, M. (author), van der Werff, S.J.A. (author), Keo, D.L. (author), Dzyubachyk, O. (author), Pereira, A.M. (author), Giltay, E.J. (author), van der Wee, N.J.A. (author), Meijer, O.C. (author), Mahfouz, A.M.E.T.A. (author)
Introduction: Cushing's disease (CD) is a rare and severe endocrine disease characterized by hypercortisolemia. Previous studies have found structural brain alterations in remitted CD patients compared to healthy controls, specifically in the anterior cingulate cortex (ACC). However, potential mechanisms through which these persistent...
journal article 2021
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Keo, D.L. (author), Dzyubachyk, Oleh (author), Van Der Grond, Jeroen (author), van Hilten, Jacobus J. (author), Reinders, M.J.T. (author), Mahfouz, A.M.E.T.A. (author)
Cortical atrophy is a common manifestation in Parkinson’s disease (PD), particularly in advanced stages of the disease. To elucidate the molecular underpinnings of cortical thickness changes in PD, we performed an integrated analysis of brain-wide healthy transcriptomic data from the Allen Human Brain Atlas and patterns of cortical thickness...
journal article 2021
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Jochems, Fleur (author), Thijssen, Bram (author), De Conti, Giulia (author), Jansen, Robin (author), Pogacar, Ziva (author), Groot, Kelvin (author), Wang, Liqin (author), Schepers, Arnout (author), Wessels, L.F.A. (author)
Cellular senescence is characterized as a stable proliferation arrest that can be triggered by multiple stresses. Most knowledge about senescent cells is obtained from studies in primary cells. However, senescence features may be different in cancer cells, since the pathways that are involved in senescence induction are often deregulated in...
journal article 2021
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Kattan, J.M. (author)
Humanity has achieved to decipher the most fundamental mechanics of cellular life. Nevertheless, despite intense efforts there are still considerable gaps in our understanding of cellular processes. Traditionally, biologists investigate life by observation of existing lifeforms. In order to assign functions to biological components, it is common...
doctoral thesis 2020
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Niemantsverdriet, Ellis (author), van den Akker, E.B. (author), Boeters, Debbie M. (author), van den Eeden, Susan J.F. (author), Geluk, Annemieke (author), van der Helm-van Mil, Annette H.M. (author)
Background: Established rheumatoid arthritis (RA) patients display differentially expressed genes coding for cytokine/chemokine-mediated immunity compared to healthy controls. It is unclear, however, if in the pre-arthritis phase of clinically suspect arthralgia (CSA) expression of immune genes differ between patients who do or do not develop...
journal article 2020
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Maire, T.T.H. (author), Allertz, T. (author), Betjes, M.A. (author), Youk, H.O. (author)
Dormancy is colloquially considered as extending lifespan by being still. Starved yeasts form dormant spores that wake-up (germinate) when nutrients reappear but cannot germinate (die) after some time. What sets their lifespans and how they age are open questions because what processes occur-and by how much-within each dormant spore remains...
journal article 2020
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Kim, S.H. (author), Ganji, M. (author), Kim, E. (author), van der Torre, J. (author), Abbondanzieri, E. (author), Dekker, C. (author)
The three-dimensional organization of DNA is increasingly understood to play a decisive role in vital cellular processes. Many studies focus on the role of DNA-packaging proteins, crowding, and confinement in arranging chromatin, but structural information might also be directly encoded in bare DNA itself. Here, we visualize plectonemes ...
journal article 2018
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Mahinrad, Simin (author), Bulk, Marjolein (author), Van Der Velpen, Isabelle (author), Mahfouz, A.M.E.T.A. (author), Van Roon-Mom, Willeke (author), Fedarko, Neal (author), Yasar, Sevil (author), Sabayan, Behnam (author), Van Heemst, Diana (author), Van Der Weerd, Louise (author)
Animal studies suggest the involvement of natriuretic peptides (NP) in several brain functions that are known to be disturbed during Alzheimer's disease (AD). However, it remains unclear whether such findings extend to humans. In this study, we aimed to: (1) map the gene expression and localization of NP and their receptors (NPR) in human...
journal article 2018
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van Nies, P.Y.B. (author)
doctoral thesis 2017
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Mahfouz, A.M.E.T.A. (author), Huisman, S.M.H. (author), Lelieveldt, B.P.F. (author), Reinders, M.J.T. (author)
The immense complexity of the mammalian brain is largely reflected in the underlying molecular signatures of its billions of cells. Brain transcriptome atlases provide valuable insights into gene expression patterns across different brain areas throughout the course of development. Such atlases allow researchers to probe the molecular mechanisms...
journal article 2017
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Doorenweerd, Nathalie (author), Mahfouz, A.M.E.T.A. (author), van Putten, Maaike (author), Kaliyaperumal, Rajaram (author), 't Hoen, Peter A.C. (author), Hendriksen, Jos G.M. (author), Aartsma-Rus, Annemieke M. (author), Verschuuren, Jan J.G.M. (author), Niks, Erik H. (author), Reinders, M.J.T. (author), Kan, Hermien E. (author), Lelieveldt, B.P.F. (author)
Duchenne muscular dystrophy (DMD) is a muscular dystrophy with high incidence of learning and behavioural problems and is associated with neurodevelopmental disorders. To gain more insights into the role of dystrophin in this cognitive phenotype, we performed a comprehensive analysis of the expression patterns of dystrophin isoforms across...
journal article 2017
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Eising, Else (author), Shyti, Reinald (author), 't Hoen, Peter A.C. (author), Vijfhuizen, L.S. (author), Huisman, S.M.H. (author), Broos, Ludo A. M. (author), Mahfouz, A.M.E.T.A. (author), Reinders, M.J.T. (author), Ferrari, Michel D. (author), Tolner, Else A. (author), de Vries, Boukje (author), van den Maagdenberg, Arn M.J.M. (author)
Familial hemiplegic migraine type 1 (FHM1) is a rare monogenic subtype of migraine with aura caused by mutations in CACNA1A that encodes the α1A subunit of voltage-gated CaV2.1 calcium channels. Transgenic knock-in mice that carry the human FHM1 R192Q missense mutation (‘FHM1 R192Q mice’) exhibit an increased susceptibility to cortical spreading...
journal article 2017
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Scott, A.D.D. (author), Noga, M.J. (author), de Graaf, P. (author), Westerlaken, I. (author), Yildirim, E. (author), Danelon, C.J.A. (author)
The goal of bottom-up synthetic biology culminates in the assembly of an entire cell from separate biological building blocks. One major challenge resides in the in vitro production and implementation of complex genetic and metabolic pathways that can support essential cellular functions. Here, we show that phospholipid biosynthesis, a multiple...
journal article 2016
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Sontrop, HMJ (author), Reinders, M.J.T. (author), Moerland, Perry D. (author)
Background: At the molecular level breast cancer comprises a heterogeneous set of subtypes associated with clear differences in gene expression and clinical outcomes. Single sample predictors (SSPs) are built via a two-stage approach consisting of clustering and subtype predictor construction based on the cluster labels of individual cases. SSPs...
journal article 2016
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Brand, H.K. (author), Ahout, I.M.L. (author), De Ridder, D. (author), Diepen, A. (author), Li, Y. (author), Zaalberg, M. (author), Andeweg, A. (author), Roeleveld, N. (author), De Groot, R. (author), Warris, A. (author), Hermans, P.W.M. (author), Ferwerda, G. (author), Staal, F.J.T. (author)
Background Respiratory viral infections follow an unpredictable clinical course in young children ranging from a common cold to respiratory failure. The transition from mild to severe disease occurs rapidly and is difficult to predict. The pathophysiology underlying disease severity has remained elusive. There is an urgent need to better...
journal article 2015
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Passtoors, W.M. (author), Van den Akker, E.B. (author), Deelen, J. (author), Maier, A.B. (author), Van der Breggen, R. (author), Jansen, R. (author), Trompet, S. (author), Van Heemst, D. (author), Derhovanessian, E. (author), Pawelec, G. (author), Van Ommen, G.J.B. (author), Slagboom, P.E. (author), Beekman, M. (author)
journal article 2015
Searched for: subject%3A%22gene%255C%2Bexpression%22
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