Searched for: subject:"gene%5C+expression"
(1 - 15 of 15)
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van Nies, P.Y.B. (author)
doctoral thesis 2017
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Sontrop, HMJ (author), Reinders, M.J.T. (author), Moerland, PD (author)
Background: At the molecular level breast cancer comprises a heterogeneous set of subtypes associated with clear differences in gene expression and clinical outcomes. Single sample predictors (SSPs) are built via a two-stage approach consisting of clustering and subtype predictor construction based on the cluster labels of individual cases. SSPs...
journal article 2016
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Mahfouz, A.M.E.T.A. (author), Huisman, S.M.H. (author), Lelieveldt, B.P.F. (author), Reinders, M.J.T. (author)
The immense complexity of the mammalian brain is largely reflected in the underlying molecular signatures of its billions of cells. Brain transcriptome atlases provide valuable insights into gene expression patterns across different brain areas throughout the course of development. Such atlases allow researchers to probe the molecular mechanisms...
journal article 2016
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Scott, A.D.D. (author), Noga, M.J. (author), de Graaf, P. (author), Westerlaken, I. (author), Yildirim, E. (author), Danelon, C.J.A. (author)
The goal of bottom-up synthetic biology culminates in the assembly of an entire cell from separate biological building blocks. One major challenge resides in the in vitro production and implementation of complex genetic and metabolic pathways that can support essential cellular functions. Here, we show that phospholipid biosynthesis, a multiple...
journal article 2016
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Eising, E (author), Shyti, R (author), 't Hoen, PAC (author), Vijfhuizen, L.S. (author), Huisman, S.M.H. (author), Broos, Ludo A. M. (author), Mahfouz, A.M.E.T.A. (author), Reinders, M.J.T. (author), Ferrari, MD (author), Tolner, EA (author), de Vries, B (author), van den Maagdenberg, AMJM (author)
Familial hemiplegic migraine type 1 (FHM1) is a rare monogenic subtype of migraine with aura caused by mutations in CACNA1A that encodes the α1A subunit of voltage-gated CaV2.1 calcium channels. Transgenic knock-in mice that carry the human FHM1 R192Q missense mutation (‘FHM1 R192Q mice’) exhibit an increased susceptibility to cortical spreading...
journal article 2016
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Brand, H.K. (author), Ahout, I.M.L. (author), De Ridder, D. (author), Diepen, A. (author), Li, Y. (author), Zaalberg, M. (author), Andeweg, A. (author), Roeleveld, N. (author), De Groot, R. (author), Warris, A. (author), Hermans, P.W.M. (author), Ferwerda, G. (author), Staal, F.J.T. (author)
Background Respiratory viral infections follow an unpredictable clinical course in young children ranging from a common cold to respiratory failure. The transition from mild to severe disease occurs rapidly and is difficult to predict. The pathophysiology underlying disease severity has remained elusive. There is an urgent need to better...
journal article 2015
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Passtoors, W.M. (author), Van den Akker, E.B. (author), Deelen, J. (author), Maier, A.B. (author), Van der Breggen, R. (author), Jansen, R. (author), Trompet, S. (author), Van Heemst, D. (author), Derhovanessian, E. (author), Pawelec, G. (author), Van Ommen, G.J.B. (author), Slagboom, P.E. (author), Beekman, M. (author)
journal article 2015
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Taskesen, E. (author), Staal, F.J.T. (author), Reinders, M.J.T. (author)
Background The wingless-Int (WNT) pathway has an essential role in cell regulation of hematopoietic stem cells (HSC). For Acute Myeloid Leukemia (AML), the malignant counterpart of HSC, currently only a selective number of genes of the WNT pathway are analyzed by using either gene expression or DNA-methylation profiles for the identification of...
journal article 2015
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Taskesen, E. (author), Babaei, S. (author), Reinders, M.J.M. (author), De Ridder, J. (author)
Background Acute Myeloid Leukemia (AML) is characterized by various cytogenetic and molecular abnormalities. Detection of these abnormalities is important in the risk-classification of patients but requires laborious experimentation. Various studies showed that gene expression profiles (GEP), and the gene signatures derived from GEP, can be used...
journal article 2015
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Sontrop, H.M.J. (author)
Microarrays offer biologists an exciting tool that allows the simultaneous assessment of gene expression levels for thousands of genes at once. At the time of their inception, microarrays were hailed as the new dawn in cancer biology and oncology practice with the hope that within a decade diseases like breast cancer would be solved. Various...
doctoral thesis 2015
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Mahfouz, A.M.E.T.A. (author), Van de Giessen, M. (author), Van der Maaten, L.J.P. (author), Huisman, S.M.H. (author), Reinders, M.J.T. (author), Hawrylycz, M.J. (author), Lelieveldt, B.P.F. (author)
The Allen Brain Atlases enable the study of spatially resolved, genome-wide gene expression patterns across the mammalian brain. Several explorative studies have applied linear dimensionality reduction methods such as Principal Component Analysis (PCA) and classical Multi-Dimensional Scaling (cMDS) to gain insight into the spatial organization...
journal article 2014
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Boulineau, S. (author)
doctoral thesis 2013
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Van Berlo, R.J.P. (author)
Bioinformatics concerns itself with developing data-driven tools for extracting biological information from high-throughput datasets (e.g. gene expression data, protein interaction data). Until recently, most of these tools focus on analyzing a single source of data. However, all high-throughput measurements are noisy and incomplete. Therefore,...
doctoral thesis 2010
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Knijnenburg, T.A. (author)
Exactly how an organism adapts its transcriptional program in response to intra- and extracellular signals remains elusive. Development of computational approaches that use the large amounts of diverse intracellular data to unravel the cell's transcriptional program is one of today's main challenges in bioinformatics research. This thesis...
doctoral thesis 2009
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Vennemann, P. (author)
The development, the regulation, and the pathology of the circulatory system (e.g. cardiogenesis, thermoregulation, atherosclerosis) are determined by blood flow induced mechanical forces. While this proposition has been confirmed during recent years, the exact mechanisms still remain unclear. This is mainly due to the fact that those forces...
doctoral thesis 2008
Searched for: subject:"gene%5C+expression"
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