Quantifying the dynamic interactions between physiological signals to predict the exposure from chemicals

Causal inference is a familiar topic in biomedical research and a key concept in the study of connectivity in various physiological systems. This work aimed to analyse the coupling between the beat to beat parameters derived from ECG and respiration. It was the first time such an analysis was carried out in the context of finding the differences...

Dynamics as a cause for the nanoscale organization of the genome

Chromatin ‘blobs’ were recently identified by live super-resolution imaging of labeled nucleosomes as pervasive but fleeting structural entities. However, the mechanisms leading to the formation of these blobs and their functional implications are unknown. We explore here whether causal relationships exist between parameters that characterize...

Quantifying directed nonlinear coupling between brain and muscle activity: a NARX model-based approach

Relevance: To enhance our understanding of motor impairments (e.g. post-stroke or due to Parkinson's Disease), objective measures for communication in the nervous system are required. By applying system identification techniques to oscillations in brain and muscle activity, we can objectively quantify the coupling between these areas.<br/><br/...

Unveiling neural coupling within the sensorimotor system: directionality and nonlinearity

Neural coupling between the central nervous system and the periphery is essential for the neural control of movement. Corticomuscular coherence is a popular linear technique to assess synchronised oscillatory activity in the sensorimotor system. This oscillatory coupling originates from ascending somatosensory feedback and descending motor...

House Price Risk and Sub-District House Price Dynamics: The Case of Amsterdam

The recent Global Financial Crisis has lent even greater urgency to the need for households to understand the risks and dynamics of the residential property market better. This paper uses a rich dataset on individual residential property transactions between 1995 and 2014 in Amsterdam to study the risks and the inter-dependency of house prices...