Searched for: subject%3A%22inflammation%22
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Slijkhuis, Nuria (author), Razzi, F. (author), Korteland, Suze Anne (author), Heijs, Bram (author), van Gaalen, Kim (author), Duncker, Dirk J. (author), van der Steen, A.F.W. (author), van Steijn, V. (author), van Beusekom, Heleen M.M. (author), van Soest, G. (author)
Coronary atherosclerosis is caused by plaque build-up, with lipids playing a pivotal role in its progression. However, lipid composition and distribution within coronary atherosclerosis remain unknown. This study aims to characterize lipids and investigate differences in lipid composition across disease stages to aid in the understanding of...
journal article 2024
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Warmink, Kelly (author), Vinod, Prateeksha (author), Korthagen, Nicoline M. (author), Weinans, Harrie (author), Rios, Jaqueline L. (author)
Osteoarthritis (OA) is a common and debilitating joint disorder that leads to progressive joint breakdown and loss of articular cartilage. Accompanied by a state of low-grade inflammation, its etiology extends beyond that of a wear-and-tear disease, and the immune system might have a role in its initiation and progression. Obesity, which is...
review 2023
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Driever, Ellen G. (author), Muntz, I.A.A. (author), Patel, Vishal (author), Adelmeijer, Jelle (author), Bernal, William (author), Koenderink, G.H. (author), Lisman, Ton (author)
Background: Previous studies identified decreased clot permeability, without differences in fibrin fiber density in clots, from patients with cirrhosis compared with those from healthy controls (HCs). Fibrinogen hypersialylation could be the reason for this discrepancy. Objectives: The aim of this work was to study mechanical properties of...
journal article 2023
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Warmink, K. (author), Rios, J. L. (author), van Valkengoed, D. R. (author), Vinod, P. (author), Korthagen, N. M. (author), Weinans, Harrie (author)
Introduction: Obesogenic diets aggravate osteoarthritis (OA) by inducing low-grade systemic inflammation, and diet composition may affect OA severity. Here, we investigated the effect of diet on joint damage and inflammation in an OA rat model. Methods: Wistar-Han rats (n = 24) were fed a chow, a high-fat (HF) diet, or a high-fat/high-sucrose...
journal article 2023
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Warmink, Kelly (author), Rios, Jaqueline L. (author), Varderidou-Minasian, Suzy (author), Torres-Torrillas, Marta (author), van Valkengoed, Devin R. (author), Versteeg, Sabine (author), Eijkelkamp, Niels (author), Weinans, Harrie (author), Korthagen, Nicoline M. (author), Lorenowicz, Magdalena J. (author)
Background: Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) hold promise as a disease modifying treatment in osteoarthritis (OA). Obesity, and its associated inflammation, contribute to OA development and metabolic OA represents a specific and significant group of the OA patient population. Given their...
journal article 2023
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Vledder, Amária (author)
Delayed healing or non-union of bone fractures are still clinically and economically relevant problems. Bone healing includes pro- and anti-inflammatory phases, which proved crucial for successful healing. Being able to modulate these inflammatory responses could potentially promote bone fracture healing. Dendritic cells play important roles in...
master thesis 2022
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Wesdorp, Marinus A. (author), Capar, Serdar (author), Bastiaansen-Jenniskens, Yvonne M. (author), Kops, Nicole (author), Creemers, Laura B. (author), Verhaar, Jan A.N. (author), van Osch, G.J.V.M. (author), Wei, Wu (author)
Background: Cartilage defects result in joint inflammation. The presence of proinflammatory factors has been described to negatively affect cartilage formation. Purpose: To evaluate the effect and timing of administration of triamcinolone acetonide (TAA), an anti-inflammatory drug, on cartilage repair using a mouse model. Study Design:...
journal article 2022
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Wesdorp, Marinus A. (author), Bastiaansen-Jenniskens, Yvonne M. (author), Capar, Serdar (author), Verhaar, Jan A.N. (author), Narcisi, R. (author), van Osch, G.J.V.M. (author)
OBJECTIVE: Inflammation is known to negatively affect cartilage repair. However, it is unclear how inflammation influences the migration of mesenchymal stromal cells (MSCs) from the underlying bone marrow into the defect. We therefore aimed to investigate how synovial inflammation influences MSC migration, and whether modulation of...
journal article 2022
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Van der Heiden, K. (author), Barrett, H. E. (author), van Gaalen, K.C. (author), Krenning, B. J. (author), Beekman, F.J. (author), Verhagen, H. J.M. (author), Norenberg, J. P. (author), de Jong, M. (author), Gijsen, F.J.H. (author)
Background: Calcification and inflammation are atherosclerotic plaque compositional biomarkers that have both been linked to stroke risk. The aim of this study was to evaluate their co-existing prevalence in human carotid plaques with respect to plaque phenotype to determine the value of hybrid imaging for the detection of these biomarkers....
journal article 2021
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Ferrao Blanco, Mauricio N. (author), Bastiaansen-Jenniskens, Yvonne M. (author), Chambers, Mark G. (author), Pitsillides, Andrew A. (author), Narcisi, Roberto (author), van Osch, G.J.V.M. (author)
Objective: In osteoarthritis, chondrocytes tend to acquire a hypertrophic phenotype, which contributes to the modification of the extracellular matrix, resulting in permanent cartilage changes. In mouse chondrocytes, pro-inflammatory macrophages and pro-inflammatory cytokines have been shown to stimulate hypertrophy via the activation of the...
journal article 2021
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Barrett, Hilary E. (author), Meester, Eric J. (author), van Gaalen, Kim (author), van der Heiden, Kim (author), Krenning, Boudewijn J. (author), Beekman, F.J. (author), Verhagen, H. J. (author), de Jong, M. (author), Gijsen, F.J.H. (author)
Purpose: Atherosclerotic plaque development and progression signifies a complex inflammatory disease mediated by a multitude of proinflammatory leukocyte subsets. Using single photon emission computed tomography (SPECT) coupled with computed tomography (CT), this study tested a new dual-isotope acquisition protocol to assess each radiotracer...
journal article 2020
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van Dijk, B. (author), Lemans, J. V.C. (author), Hoogendoorn, R. M. (author), Dadachova, E. (author), de Klerk, J. M.H. (author), Vogely, H. C. (author), Weinans, Harrie (author), Lam, M. G.E.H. (author), van der Wal, B. C.H. (author)
BACKGROUND: Widespread use and misuse of antibiotics have led to a dramatic increase in the emergence of antibiotic resistant bacteria, while the discovery and development of new antibiotics is declining. This has made certain implant-associated infections such as periprosthetic joint infections, where a biofilm is formed, very difficult to...
review 2020
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Kozijn, A. E. (author), Tartjiono, M. T. (author), Ravipati, S. (author), van der Ham, F. (author), Barrett, D. A. (author), Mastbergen, S. C. (author), Korthagen, N. M. (author), Lafeber, F. P.J.G. (author), Zuurmond, A. M. (author), Bobeldijk, I. (author), Weinans, Harrie (author), Stoop, R. (author)
Objective: C-reactive protein (CRP) levels can be elevated in osteoarthritis (OA) patients. In addition to indicating systemic inflammation, it is suggested that CRP itself can play a role in OA development. Obesity and metabolic syndrome are important risk factors for OA and also induce elevated CRP levels. Here we evaluated in a human CRP ...
journal article 2019
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Aizenberg, Evgeni (author), Roex, Edgar A.H. (author), Nieuwenhuis, Wouter P. (author), Mangnus, Lukas (author), van der Helm-Mil, Annette H.M. (author), Reijnierse, Monique (author), Bloem, Johan L. (author), Lelieveldt, B.P.F. (author), Stoel, Berend G. (author)
Purpose: To investigate the feasibility of automatic quantification of bone marrow edema (BME) on MRI of the wrist in patients with early arthritis. <br clear="none"/>Methods: For 485 early arthritis patients (clinically confirmed arthritis of one or more joints, symptoms for less than 2 years), MR scans of the wrist were processed in three...
journal article 2018
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de Visser, H.M. (author), Korthagen, NM (author), Müller, C. (author), Ramakers, R.M. (author), Krijger, G.C. (author), Lafeber, F.P.J.G. (author), Beekman, F.J. (author), Mastbergen, S.C. (author), Weinans, Harrie (author)
Objective. To evaluate the presence and localization of folate receptor expressing macrophages in the rat groove model of osteoarthritis and determine the suitability of a new folate conjugate with albumin-binding entity (cm09) for in vivo SPECT (single-photon emission computed tomography) analysis. Design. In male Wistar rats, local cartilage...
journal article 2018
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Berger, Marieke (author), de Boer, Johannes D. (author), Lutter, René (author), Makkee, M. (author), Sterk, Peter J. (author), Kemper, Elles M. (author), van der Zee, Jaring S. (author)
Background: Inhalation of particulate matter, as part of air pollution, is associated with increased morbidity and mortality. Nanoparticles (&lt; 100nm) are likely candidates for triggering inflammatory responses and activation of coagulation pathways because of their ability to enter lung cells and pass bronchial mucosa. We tested the...
journal article 2017
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Eising, Else (author), Shyti, Reinald (author), 't Hoen, Peter A.C. (author), Vijfhuizen, L.S. (author), Huisman, S.M.H. (author), Broos, Ludo A. M. (author), Mahfouz, A.M.E.T.A. (author), Reinders, M.J.T. (author), Ferrari, Michel D. (author), Tolner, Else A. (author), de Vries, Boukje (author), van den Maagdenberg, Arn M.J.M. (author)
Familial hemiplegic migraine type 1 (FHM1) is a rare monogenic subtype of migraine with aura caused by mutations in CACNA1A that encodes the α1A subunit of voltage-gated CaV2.1 calcium channels. Transgenic knock-in mice that carry the human FHM1 R192Q missense mutation (‘FHM1 R192Q mice’) exhibit an increased susceptibility to cortical spreading...
journal article 2017
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Aizenberg, Evgeni (author), van den Berg, Rosaline (author), Ez-Zaitouni, Zineb (author), van der Heijde, Désirée (author), Reijnierse, Monique (author), Dzyubachyk, Oleh (author), Lelieveldt, B.P.F. (author)
Background: Evaluating inflammatory changes over time on MR images of the spine in patients with suspected axial Spondyloarthritis (axSpA) can be a labor-intensive task, requiring readers to manually search for and perceptually align a set of vertebrae between two scans. The purpose of this study was to assess the feasibility of computer...
journal article 2017
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Kersten, Kelly (author), Coffelt, Seth B. (author), Hoogstraat, Marlous (author), Verstegen, Niels J.M. (author), Vrijland, Kim (author), Ciampricotti, Metamia (author), Doornebal, Chris W. (author), Hau, Cheei-Sing (author), Wellenstein, Max D. (author), Salvagno, Camilla (author), Doshi, Parul (author), Lips, Esther H. (author), Wessels, L.F.A. (author), de Visser, Karin E. (author)
Patients with primary solid malignancies frequently exhibit signs of systemic inflammation. Notably, elevated levels of neutrophils and their associated soluble mediators are regularly observed in cancer patients, and correlate with reduced survival and increased metastasis formation. Recently, we demonstrated a mechanistic link between...
journal article 2017
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Jong, Willeke M.C. (author), ten Cate, Hugo (author), Linnenbank, A.C. (author), de Boer, Onno J. (author), Reitsma, Pieter H. (author), de Winter, Robbert J. (author), Zuurbier, Coert (author)
Objective and design: We examined the role of IL-6 in the temporal development of cardiac ischemia–reperfusion injury employing a closed-chest I/R model. Materials/methods: Infarction, local and systemic inflammation, neutrophil infiltration, coagulation and ST elevation/resolution were compared between wild-type (WT) and IL-6-deficient (IL-6...
journal article 2016
Searched for: subject%3A%22inflammation%22
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