Searched for: subject%3A%22ipsc%22
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Castillo Ransanz, LucĂ­a (author), van Altena, P.F.J. (author), Heine, Vivi M. (author), Accardo, A. (author)
The biomechanical properties of the brain microenvironment, which is composed of different neural cell types, the extracellular matrix, and blood vessels, are critical for normal brain development and neural functioning. Stiffness, viscoelasticity and spatial organization of brain tissue modulate proliferation, migration, differentiation, and...
review 2022
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Hung, Christy (author), Tuck, Eleanor (author), Stubbs, Victoria (author), van der Lee, S.J. (author), Aalfs, Cora (author), van Spaendonk, Resie (author), Scheltens, Philip (author), Hardy, John (author), Holstege, H. (author)
Dysfunction of the endolysosomal-autophagy network is emerging as an important pathogenic process in Alzheimer's disease. Mutations in the sorting receptor-encoding gene SORL1 cause autosomal-dominant Alzheimer's disease, and SORL1 variants increase risk for late-onset AD. To understand the contribution of SORL1 mutations to AD pathogenesis,...
journal article 2021
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Rikalo, N. (author)
Human induced pluripotent stem cells (hiPSCs) offer the possibility to model human disease and study their behavior. They help scientists discover early disease-causing events in cells and are therefore used in discoveries about premature aging, congenital heart disease, cancer, and disorders connected to fetal development. Because of their...
master thesis 2020
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Ibsen, Oscar (author)
Context. In times where human kind is facing serious challenges due to global warming, scarcity of natural resources and inequality, to continue producing food, especially meat, as it is now done, does not seem sustainable. For people that want to continue enjoying their delicious piece of steak, the manner in which meat is sourced will need to...
master thesis 2020
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Gaio, N. (author)
Over the last few years the need of new alternatives to traditional disease modelling, drug screening and toxicity tests has boosted the development of a new class of devices called Organ on Chip. These usually consist in a substrate or a well in which cells are cultured with the aim of differentiating them in a particular tissue lineage. With...
master thesis 2015
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